{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:25:59Z","timestamp":1791822359918,"version":"4.3.4"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"16","license":[{"start":{"date-parts":[[2007,8,15]],"date-time":"2007-08-15T00:00:00Z","timestamp":1187136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2007,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Mycoplasma gallisepticum<\/jats:italic>\n            is an etiologic agent of chronic respiratory disease in chickens and infectious sinusitis in turkeys. Other than proteins important for cytadherence, few\n            <jats:italic>M. gallisepticum<\/jats:italic>\n            factors or pathways contributing to host cell interactions have been identified. In this study, an oligonucleotide-based microarray was utilized to investigate transcriptional changes in\n            <jats:italic>M. gallisepticum<\/jats:italic>\n            strain R\n            <jats:sub>low<\/jats:sub>\n            upon exposure to eukaryotic cells. Fifty-eight genes were either up- or downregulated upon exposure to MRC-5 lung fibroblasts grown in vitro, including genes encoding transport-, metabolism-, and translation-associated proteins. Twenty of the 58 regulated genes have no assigned function. These results indicate that\n            <jats:italic>M. gallisepticum<\/jats:italic>\n            regulates gene expression upon exposure to eukaryotic cells, revealing genes and pathways likely to be important for host-bacterium interaction.\n          <\/jats:p>","DOI":"10.1128\/jb.00667-07","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T04:56:59Z","timestamp":1181365019000},"page":"5803-5807","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Transcriptional Responses of\n            <i>Mycoplasma gallisepticum<\/i>\n            Strain R in Association with Eukaryotic Cells"],"prefix":"10.1128","volume":"189","author":[{"given":"Katharine R.","family":"Cecchini","sequence":"first","affiliation":[{"name":"Center of Excellence for Vaccine Research"},{"name":"Department of Pathobiology and Veterinary Sciences, University of Connecticut, Storrs, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy S.","family":"Gorton","sequence":"additional","affiliation":[{"name":"Center of Excellence for Vaccine Research"},{"name":"Department of Pathobiology and Veterinary Sciences, University of Connecticut, Storrs, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Geary","sequence":"additional","affiliation":[{"name":"Center of Excellence for Vaccine Research"},{"name":"Department of Pathobiology and Veterinary Sciences, University of Connecticut, Storrs, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_3_2_3_2","first-page":"285","volume":"23","year":"1965","unstructured":"Hayflick, L. 1965. Tissue cultures and mycoplasmas. Tex. Rep. Biol. Med. 23(Suppl. 1): 285.","journal-title":"Tex. Rep. Biol. Med."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.2.931-939.2006"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"480","DOI":"10.2307\/1592250","volume":"40","year":"1996","unstructured":"Ley, D. H., J. E. Berkhoff, and J. M. McLaren. 1996. Mycoplasma gallisepticum isolated from house finches (Carpodacus mexicanus) with conjunctivitis. Avian Dis. 40 : 480-483.","journal-title":"Avian Dis."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.1.160-166.2006"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1099\/mic.0.28674-0","volume":"152","year":"2006","unstructured":"Madsen, M. L., D. Nettleton, E. L. Thacker, and F. C. Minion. 2006. Transcriptional profiling of Mycoplasma hyopneumoniae during iron depletion using microarrays. Microbiology 152 : 937-944.","journal-title":"Microbiology"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.8.2538-2547.2003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/bib\/6.4.318","volume":"6","year":"2005","unstructured":"Meiklejohn, C. D., and J. P. Townsend. 2005. A Bayesian method for analysing spotted microarray data. Brief. Bioinform. 6 : 318-330.","journal-title":"Brief. Bioinform."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.7.3812-3820.2003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.12.6839-6845.2002"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1099\/mic.0.26427-0","volume":"149","year":"2003","unstructured":"Papazisi, L., T. S. Gorton, G. Kutish, P. F. Markham, G. F. Browning, D. K. Nguyen, S. Swartzell, A. Madan, G. Mahairas, and S. J. Geary. 2003. The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R(low). Microbiology 149 : 2307-2316.","journal-title":"Microbiology"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.12.6643-6649.2000"},{"key":"e_1_3_2_14_2","first-page":"181","year":"1992","unstructured":"Pollack, J. D. 1992. Carbohydrate metabolism and energy conservation, p. 181-200. In J. Maniloff (ed.), Mycoplasmas: molecular biology and pathogenesis. American Society for Microbiology, Washington, DC.","journal-title":"Mycoplasmas: molecular biology and pathogenesis."},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0966-842X(97)01113-X","volume":"5","year":"1997","unstructured":"Pollack, J. D. 1997. Mycoplasma genes: a case for reflective annotation. 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