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FtsZ serves as a master regulator for this process, and its function is highly dependent on both its assembly into the canonical Z ring and interactions with protein binding partners, all of which results in the activation of enzymes that remodel the cell wall to drive constriction. Using mutants of FtsZ, we have elaborated on the role of its C-terminal linker domain in regulating Z-ring stability and dynamics, as well as the requirement for its conserved C-terminal domain and interaction with the membrane-anchoring protein FtsA for regulating the process of cell wall remodeling for constriction.<\/jats:p>","DOI":"10.1128\/jb.00693-19","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T12:44:51Z","timestamp":1578919491000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["FtsA Regulates Z-Ring Morphology and Cell Wall Metabolism in an FtsZ C-Terminal Linker-Dependent Manner in Caulobacter crescentus"],"prefix":"10.1128","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9693-0207","authenticated-orcid":false,"given":"Jordan M.","family":"Barrows","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousik","family":"Sundararajan","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anant","family":"Bhargava","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8518-2303","authenticated-orcid":false,"given":"Erin D.","family":"Goley","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00021-10"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.08.027"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07677.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8281"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aak9995"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aak9973"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-003-2523-5"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/34465"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/34472"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.809939"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052595099"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.22895"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2019.04.011"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04522.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.17.5551-5559.1997"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00752.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.24.7531-7544.1999"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2439"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009810200"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13388"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12272"},{"key":"e_1_3_3_23_2","doi-asserted-by":"crossref","unstructured":"Howell M Aliashkevich A Sundararajan K Daniel JJ Lariviere PJ Goley ED Cava F Brown PJB. 2018. 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