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Despite the recent sequencing of the genome of the pathogen\n            <jats:italic>L. interrogans<\/jats:italic>\n            , the slow growth of these bacteria, their virulence in humans, and a lack of genetic tools make it difficult to work with these pathogens. In contrast, the development of numerous genetic tools for the saprophyte\n            <jats:italic>L. biflexa<\/jats:italic>\n            enables its use as a model bacterium.\n            <jats:italic>Leptospira<\/jats:italic>\n            spp. require iron for growth. In this work, we show that\n            <jats:italic>Leptospira<\/jats:italic>\n            spp. can acquire iron from different sources, including siderophores. A comparative genome analysis of iron uptake systems and their regulation in the saprophyte\n            <jats:italic>L. biflexa<\/jats:italic>\n            and the pathogen\n            <jats:italic>L. interrogans<\/jats:italic>\n            is presented in this study. Our data indicated that, for instance,\n            <jats:italic>L. biflexa<\/jats:italic>\n            and\n            <jats:italic>L. interrogans<\/jats:italic>\n            contain 8 and 12 genes, respectively, whose products share homology with proteins that have been shown to be TonB-dependent receptors. We show that some genes involved in iron uptake were differentially expressed in response to iron. In addition, we were able to disrupt several putative genes involved in iron acquisition systems or iron regulation in\n            <jats:italic>L. biflexa<\/jats:italic>\n            . Comparative genomics, in combination with gene inactivation, gives us significant functional information on iron homeostasis in\n            <jats:italic>Leptospira<\/jats:italic>\n            spp.\n          <\/jats:p>","DOI":"10.1128\/jb.00711-06","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T18:24:30Z","timestamp":1162491870000},"page":"7893-7904","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":71,"title":["Comparative and Functional Genomic Analyses of Iron Transport and Regulation in\n            <i>Leptospira<\/i>\n            spp"],"prefix":"10.1128","volume":"188","author":[{"given":"H.","family":"Louvel","sequence":"first","affiliation":[{"name":"Laboratoire des Spiroche\u0300tes, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bommezzadri","sequence":"additional","affiliation":[{"name":"Laboratoire des Spiroche\u0300tes, Institut Pasteur, Paris, France"},{"name":"Department of Pathology and Laboratory Medicine, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Zidane","sequence":"additional","affiliation":[{"name":"Plate-forme Ge\u0301nomique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Boursaux-Eude","sequence":"additional","affiliation":[{"name":"Plate-forme Inte\u0301gration et Analyse Ge\u0301nomiques, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Creno","sequence":"additional","affiliation":[{"name":"Plate-forme Ge\u0301nomique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Magnier","sequence":"additional","affiliation":[{"name":"Plate-forme Ge\u0301nomique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Rouy","sequence":"additional","affiliation":[{"name":"Pasteur Genopole Ile de France, Genoscope, and CNRS-UMR8030, Atelier de Ge\u0301nomique Comparative, Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Me\u0301digue","sequence":"additional","affiliation":[{"name":"Pasteur Genopole Ile de France, Genoscope, and CNRS-UMR8030, Atelier de Ge\u0301nomique Comparative, Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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