{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:23:16Z","timestamp":1790695396655,"version":"4.1.0"},"reference-count":59,"publisher":"American Society for Microbiology","issue":"14","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM103418"],"award-info":[{"award-number":["P20GM103418"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM113117"],"award-info":[{"award-number":["P20GM113117"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007765","name":"Kansas State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2019,7,15]]},"abstract":"<jats:p>\n            <jats:italic>Legionella<\/jats:italic>\n            spp. are natural pathogens of protozoa and accidental pathogens of humans. Innate immunity in healthy individuals effectively controls\n            <jats:italic>Legionella<\/jats:italic>\n            infection due in part to rapid and robust production of proinflammatory cytokines resulting from detection of Dot\/Icm-translocated substrates, including effectors. Here, we demonstrate that the effector LegC4 enhances proinflammatory host restriction of\n            <jats:italic>Legionella<\/jats:italic>\n            by macrophages. These data suggest that LegC4 may augment proinflammatory signaling or antimicrobial activity of macrophages, a function that has not previously been observed for another bacterial effector. Further insight into LegC4 function will likely reveal novel mechanisms to enhance immunity against pathogens.\n          <\/jats:p>","DOI":"10.1128\/jb.00755-18","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T12:40:48Z","timestamp":1556196048000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Potentiation of Cytokine-Mediated Restriction of\n            <i>Legionella<\/i>\n            Intracellular Replication by a Dot\/Icm-Translocated Effector"],"prefix":"10.1128","volume":"201","author":[{"given":"Tshegofatso","family":"Ngwaga","sequence":"first","affiliation":[{"name":"Division of Biology, Kansas State University, Manhattan, Kansas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex J.","family":"Hydock","sequence":"additional","affiliation":[{"name":"Division of Biology, Kansas State University, Manhattan, Kansas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2278-1405","authenticated-orcid":false,"given":"Stephanie R.","family":"Shames","sequence":"additional","affiliation":[{"name":"Division of Biology, Kansas State University, Manhattan, Kansas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1967"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00052-09"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/341087"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep26261"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu430"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02049-05"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.12.8181"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394318-7.00003-6"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3MR0916-380R"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020018"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.9.5720-5734.2005"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01382-08"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211521110"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2010.05.006"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M604638200"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1501289112"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/516530"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.9.3253-3258.1995"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2820"},{"key":"e_1_3_3_21_2","first-page":"1537","article-title":"Replicative Legionella pneumophila lung infection in intratracheally inoculated A\/J mice. 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