{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:13:36Z","timestamp":1787588016324,"version":"build-2736575974"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"13","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-97888"],"award-info":[{"award-number":["MOP-97888"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-142466"],"award-info":[{"award-number":["MOP-142466"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2020,6,9]]},"abstract":"<jats:p>\n                    Coordination of the expression of genes associated with bacterial virulence and environmental adaptation is often dependent on quorum sensing (QS). The QS circuitry of the nonpathogenic bacterium\n                    <jats:named-content content-type=\"genus-species\">Burkholderia thailandensis<\/jats:named-content>\n                    , widely used as a model system for the study of the human pathogen\n                    <jats:named-content content-type=\"genus-species\">Burkholderia pseudomallei<\/jats:named-content>\n                    , is complex. We found that the LysR-type transcriptional regulator, ScmR, which is highly conserved and involved in the control of virulence\/survival factors in the\n                    <jats:italic>Burkholderia<\/jats:italic>\n                    genus, is a global regulator mediating gene expression through the multiple QS systems coexisting in\n                    <jats:named-content content-type=\"genus-species\">B. thailandensis<\/jats:named-content>\n                    , as well as QS independently. We conclude that ScmR represents a key QS modulatory network element, ensuring tight regulation of the transcription of QS-controlled genes, particularly those required for acclimatization to the environment.\n                  <\/jats:p>","DOI":"10.1128\/jb.00776-19","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T11:33:12Z","timestamp":1587123192000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["ScmR, a Global Regulator of Gene Expression, Quorum Sensing, pH Homeostasis, and Virulence in\n                    <i>Burkholderia thailandensis<\/i>"],"prefix":"10.1128","volume":"202","author":[{"given":"Servane","family":"Le Guillouzer","sequence":"first","affiliation":[{"name":"Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique, Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Groleau","sequence":"additional","affiliation":[{"name":"Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique, Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Mauffrey","sequence":"additional","affiliation":[{"name":"Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique, Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4609-0115","authenticated-orcid":false,"given":"Eric","family":"D\u00e9ziel","sequence":"additional","affiliation":[{"name":"Centre Armand-Frappier Sant\u00e9 Biotechnologie, Institut National de la Recherche Scientifique, Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.2.269-275.1994"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.104.1.313-322.1970"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm907"},{"key":"e_1_3_3_5_2","first-page":"40","volume-title":"Regulation of bacterial virulence","author":"Majerczyk CD","year":"2013","unstructured":"Majerczyk CD, Greenberg EP, Chandler JR. 2013. 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