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Disruption of the Rv0348 gene from the genome of the virulent H37Rv strain of\n            <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n            revealed a global impact on the transcriptional profiles of 163 genes, including induction of the mammalian cell entry (\n            <jats:italic>mce1<\/jats:italic>\n            ) operon and the repression of a significant number of genes involved in hypoxia and starvation responses. Nonetheless, gel shift assays did not reveal direct binding between Rv0348 and a set of regulated promoters, suggesting an indirect regulatory role. However, when expressed in\n            <jats:italic>Mycobacterium smegmatis<\/jats:italic>\n            , the Rv0348 transcripts were significantly responsive to different levels of hypoxia and the encoded protein was shown to regulate genes involved in hypoxia [e.g., Rv3130c (\n            <jats:italic>tgs1<\/jats:italic>\n            )] and intracellular survival (e.g.,\n            <jats:italic>mce1<\/jats:italic>\n            ), among other genes. Interestingly, the colonization level of the \u0394\n            <jats:italic>mosR<\/jats:italic>\n            mutant strain was significantly lower than that of the wild-type strain of\n            <jats:italic>M. tuberculosis<\/jats:italic>\n            , suggesting its attenuation in the murine model of tuberculosis. Taken together, our analyses indicated that the Rv0348 gene encodes a novel transcriptional factor that regulates several operons involved in mycobacterial survival, especially during hypoxia; hence, we propose that Rv0348 be renamed\n            <jats:italic>mosR<\/jats:italic>\n            for\n            <jats:italic>r<\/jats:italic>\n            egulator of\n            <jats:italic>m<\/jats:italic>\n            ycobacterial\n            <jats:italic>o<\/jats:italic>\n            perons of\n            <jats:italic>s<\/jats:italic>\n            urvival.\n          <\/jats:p>","DOI":"10.1128\/jb.00778-09","type":"journal-article","created":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T01:10:02Z","timestamp":1249089002000},"page":"5941-5952","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["<i>mosR<\/i>\n            , a Novel Transcriptional Regulator of Hypoxia and Virulence in\n            <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1128","volume":"191","author":[{"given":"Bassam","family":"Abomoelak","sequence":"first","affiliation":[{"name":"Laboratory of Bacterial Genomics, Department of Pathobiological Sciences, University of Wisconsin\u2014Madison, 1656 Linden Drive, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Hoye","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Genomics, Department of Pathobiological Sciences, University of Wisconsin\u2014Madison, 1656 Linden Drive, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chi","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Genomics, Department of Pathobiological Sciences, University of Wisconsin\u2014Madison, 1656 Linden Drive, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Marcus","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Genomics, Department of Pathobiological Sciences, University of Wisconsin\u2014Madison, 1656 Linden Drive, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francoise","family":"Laval","sequence":"additional","affiliation":[{"name":"CNRS, Institut de Pharmacologie et de Biologie Structurale"},{"name":"Paul Sabatier University, 205 Route de Narbonne, 31077 Toulouse Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Bannantine","sequence":"additional","affiliation":[{"name":"National Animal Disease Center, Ames, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Ward","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Genomics, Department of Pathobiological Sciences, University of Wisconsin\u2014Madison, 1656 Linden Drive, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamadou","family":"Daffe\u0301","sequence":"additional","affiliation":[{"name":"CNRS, Institut de Pharmacologie et de Biologie Structurale"},{"name":"Paul Sabatier University, 205 Route de Narbonne, 31077 Toulouse Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Di","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Genomics, Department of Pathobiological Sciences, University of Wisconsin\u2014Madison, 1656 Linden Drive, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel M.","family":"Talaat","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Genomics, Department of Pathobiological Sciences, University of Wisconsin\u2014Madison, 1656 Linden Drive, Madison, Wisconsin 53706"},{"name":"Department of Food Hygiene, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.tube.2008.03.005","volume":"88","year":"2008","unstructured":"Andreu, N., and I. 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