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Although most of the residues involved in ligand interaction are conserved, these chemoreceptors show different affinities for the same ligand and play different cellular roles. A series of ligand complex structures of the periplasmic region of Mlp24 (Mlp24p) and following ITC analysis revealed that Ca\n            <jats:sup>2+<\/jats:sup>\n            binds to the loop of Mlp24p and modulates the ligand binding affinity of Mlp24p. Moreover, Ca\n            <jats:sup>2+<\/jats:sup>\n            changes the chemotactic behaviors mediated by Mlp24. We propose that Ca\n            <jats:sup>2+<\/jats:sup>\n            acts as a cosignal that modulates the affinity of Mlp24 for the primary signal, thereby changing the chemotactic behavior of\n            <jats:named-content content-type=\"genus-species\">V. cholerae<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/jb.00779-18","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T11:59:06Z","timestamp":1549886346000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Calcium Ions Modulate Amino Acid Sensing of the Chemoreceptor Mlp24 of\n            <i>Vibrio cholerae<\/i>"],"prefix":"10.1128","volume":"201","author":[{"given":"Yohei","family":"Takahashi","sequence":"first","affiliation":[{"name":"Graduate School of Science, Osaka University, Toyonaka, Osaka, 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