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Bacteria use myriad strategies to defend against phage infection, including restriction modification, abortive infection, phase variation of cell surface receptors, phage-inducible chromosomal islands, and clustered regularly interspaced short palindromic repeat(s) (CRISPR)-Cas systems. The data presented here suggest that the apparently passive process of OMV release can also contribute to phage defense. By considering the effect of OMVs on\n                    <jats:named-content content-type=\"genus-species\">V. cholerae<\/jats:named-content>\n                    infection by three unique virulent phages, ICP1, ICP2, and ICP3, we show that,\n                    <jats:italic>in vitro<\/jats:italic>\n                    , a reproducible reduction in bacterial killing is both dose and phage receptor dependent. This work supports a role for OMVs as natural decoys to defend bacteria from phage predation.\n                  <\/jats:p>","DOI":"10.1128\/jb.00792-17","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:50:56Z","timestamp":1523944256000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":179,"title":["Vibrio cholerae Outer Membrane Vesicles Inhibit Bacteriophage Infection"],"prefix":"10.1128","volume":"200","author":[{"given":"Tamara","family":"Reyes-Robles","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Microbiology, Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca S.","family":"Dillard","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, 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