{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T10:30:06Z","timestamp":1749033006887},"reference-count":75,"publisher":"American Society for Microbiology","issue":"21","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Relapsing fever is a worldwide, endemic disease caused by several spirochetal species belonging to the genus\n            <jats:italic>Borrelia<\/jats:italic>\n            . During the recurring fever peaks, borreliae proliferate remarkably quickly compared to the slow dissemination of Lyme disease\n            <jats:italic>Borrelia<\/jats:italic>\n            and therefore require efficient nutrient uptake from the blood of their hosts. This study describes the identification and characterization of the first relapsing fever porin, which is present in the outer membranes of\n            <jats:italic>B. duttonii<\/jats:italic>\n            ,\n            <jats:italic>B. hermsii<\/jats:italic>\n            ,\n            <jats:italic>B. recurrentis<\/jats:italic>\n            , and\n            <jats:italic>B. turicatae<\/jats:italic>\n            . The pore-forming protein was purified by hydroxyapatite chromatography and designated Oms38, for outer membrane-spanning protein of 38 kDa. Biophysical characterization of Oms38 was done by using the black lipid bilayer method, demonstrating that Oms38 forms small, water-filled channels of 80 pS in 1 M KCl that did not exhibit voltage-dependent closure. The Oms38 channel is slightly selective for anions and shows a ratio of permeability for cations over anions of 0.41 in KCl. Analysis of the deduced amino acid sequences demonstrated that Oms38 contains an N-terminal signal sequence which is processed under in vivo conditions. Oms38 is highly conserved within the four studied relapsing fever species, sharing an overall amino acid identity of 58% and with a strong indication for the presence of amphipathic \u03b2-sheets.\n          <\/jats:p>","DOI":"10.1128\/jb.00818-08","type":"journal-article","created":{"date-parts":[[2008,8,30]],"date-time":"2008-08-30T00:46:34Z","timestamp":1220057194000},"page":"7035-7042","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Oms38 Is the First Identified Pore-Forming Protein in the Outer Membrane of Relapsing Fever Spirochetes"],"prefix":"10.1128","volume":"190","author":[{"given":"Marcus","family":"Thein","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Biocenter, University of Wu\u0308rzburg, Wu\u0308rzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignas","family":"Bunikis","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Umea\u030a University, Umea\u030a, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Denker","sequence":"additional","affiliation":[{"name":"Rudolf-Virchow-Center, DFG-Research Center for Experimental Biomedicine, University of Wu\u0308rzburg, Wu\u0308rzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Umea\u030a University, Umea\u030a, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Cutler","sequence":"additional","affiliation":[{"name":"University of East London, School of Health and Bioscience, Stratford, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Drancourt","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020, IFR 48, Universite\u0301 de la Me\u0301diterrane\u0301e, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom G.","family":"Schwan","sequence":"additional","affiliation":[{"name":"Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Mentele","sequence":"additional","affiliation":[{"name":"Max-Planck Institute of Biochemistry, Martinsried, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich","family":"Lottspeich","sequence":"additional","affiliation":[{"name":"Max-Planck Institute of Biochemistry, Martinsried, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Bergstro\u0308m","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Umea\u030a University, Umea\u030a, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Benz","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Biocenter, University of Wu\u0308rzburg, Wu\u0308rzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2105-5-29","volume":"5","year":"2004","unstructured":"Bagos, P. G., T. D. Liakopoulos, I. C. Spyropoulos, and S. J. Hamodrakas. 2004. A hidden Markov model method, capable of predicting and discriminating beta-barrel outer membrane proteins. BMC Bioinformatics 5 : 29.","journal-title":"BMC Bioinformatics"},{"key":"e_1_3_2_3_2","first-page":"972","year":"2002","unstructured":"Barbour, A. G. 2002. Antigenic variation of relapsing fever Borrelia and other pathogenic bacteria, p. 972-994, Mobile DNA II. American Society for Microbiology, Washington, DC.","journal-title":"Antigenic variation of relapsing fever Borrelia and other pathogenic bacteria"},{"key":"e_1_3_2_4_2","first-page":"521","volume":"57","year":"1984","unstructured":"Barbour, A. G. 1984. Isolation and cultivation of Lyme disease spirochetes. Yale J. Biol. Med. 57 : 521-525.","journal-title":"Yale J. Biol. Med."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.12.7114-7121.2000"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"18290","DOI":"10.1073\/pnas.0605302103","volume":"103","year":"2006","unstructured":"Barbour, A. G., Q. Dai, B. I. Restrepo, H. G. Stoenner, and S. A. Frank. 2006. Pathogen escape from host immunity by a genome program for antigenic variation. Proc. Natl. Acad. Sci. USA 103 : 18290-18295.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.8.2151-2157.1994"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.05.028"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0304-4157(94)90004-3","volume":"1197","year":"1994","unstructured":"Benz, R. 1994. Permeation of hydrophilic solutes through mitochondrial outer membranes: review on mitochondrial porins. Biochim. Biophys. Acta 1197 : 167-196.","journal-title":"Biochim. Biophys. Acta"},{"key":"e_1_3_2_10_2","first-page":"227","year":"2001","unstructured":"Benz, R. 2001. Porins\u2014structure and function, p. 227-246. In G. Winkelmann (ed.), Microbial transport systems. Wiley-VCH Verlag GmbH, Weinheim, Germany.","journal-title":"Microbial transport systems"},{"key":"e_1_3_2_11_2","first-page":"397","year":"1994","unstructured":"Benz, R. 1994. Solute uptake through bacterial outer membranes, p. 397-423. In G. J. M. Hackenbek (ed.), Bacterial cell wall. Elsevier Science B. V., Amsterdam, The Netherlands.","journal-title":"Bacterial cell wall"},{"key":"e_1_3_2_12_2","first-page":"259","year":"2004","unstructured":"Benz, R. 2004. Structure and function of mitochondrial (eukaryotic) porins, p. 259-284. In R. Benz (ed.), Structure and function of prokaryotic and eukaryotic porins. Wiley-VCH Verlag GmbH, Weinheim, Germany.","journal-title":"Structure and function of prokaryotic and eukaryotic porins"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0005-2736(78)90269-9","volume":"511","year":"1978","unstructured":"Benz, R., K. Janko, W. Boos, and P. L\u00e4uger. 1978. Formation of large, ion-permeable membrane channels by the matrix protein (porin) of Escherichia coli. Biochim. Biophys. Acta 511 : 305-319.","journal-title":"Biochim. Biophys. Acta"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0005-2736(89)90002-3","volume":"551","year":"1979","unstructured":"Benz, R., K. Janko, and P. L\u00e4uger. 1979. Ionic selectivity of pores formed by the matrix protein (porin) of Escherichia coli. Biochim. Biophys. Acta 551 : 238-247.","journal-title":"Biochim. Biophys. Acta"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1432-1033.1988.tb14333.x","volume":"176","year":"1988","unstructured":"Benz, R., A. Schmid, C. Maier, and E. Bremer. 1988. Characterization of the nucleoside-binding site inside the Tsx channel of Escherichia coli outer membrane. Reconstitution experiments with lipid bilayer membranes. Eur. J. Biochem. 176 : 699-705.","journal-title":"Eur. J. Biochem."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.165.3.978-986.1986"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF02209137","volume":"100","year":"1987","unstructured":"Benz, R., A. Schmid, and G. H. Vos-Scheperkeuter. 1987. Mechanism of sugar transport through the sugar-specific LamB channel of Escherichia coli outer membrane. J. Membr. Biol. 100 : 21-29.","journal-title":"J. Membr. Biol."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.9.3625-3635.1993"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/elps.1150080203","volume":"8","year":"1987","unstructured":"Blum, H., H. Beier, and H. J. Gross. 1987. Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels. Electrophoresis 8 : 93-99.","journal-title":"Electrophoresis"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/02724936.1985.11748384","volume":"5","year":"1985","unstructured":"Brasseur, D. 1985. Tick-borne relapsing fever in a premature infant. Ann. Trop. Paediatr. 5 : 161-162.","journal-title":"Ann. Trop. Paediatr."},{"key":"e_1_3_2_21_2","first-page":"129","volume":"39","year":"1970","unstructured":"Bryceson, A. D., E. H. Parry, P. L. Perine, D. A. Warrell, D. Vukotich, and C. S. Leithead. 1970. Louse-borne relapsing fever. Q. J. Med. 39 : 129-170.","journal-title":"Q. J. Med."},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"e1000009","DOI":"10.1371\/journal.ppat.1000009","volume":"4","year":"2008","unstructured":"Bunikis, I., K. Denker, Y. \u00d6stberg, C. Andersen, R. Benz, and S. Bergstr\u00f6m. 2008. An RND-type efflux system in Borrelia burgdorferi is involved in virulence and resistance to antimicrobial compounds. PLoS Pathog. 4 : e1000009.","journal-title":"PLoS Pathog."},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1574-6968.1995.tb07768.x","volume":"131","year":"1995","unstructured":"Bunikis, J., L. Noppa, and S. Bergstr\u00f6m. 1995. Molecular analysis of a 66-kDa protein associated with the outer membrane of Lyme disease Borrelia. FEMS Microbiol. Lett. 131 : 139-145.","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.8.3352-3360.1997"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.7.2792-2799.1994"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"s265","DOI":"10.2741\/1046","volume":"8","year":"2003","unstructured":"Charbit, A. 2003. Maltodextrin transport through lamb. Front Biosci. 8 : s265-74.","journal-title":"Front Biosci."},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1093\/nar\/gkg500","volume":"31","year":"2003","unstructured":"Chenna, R., H. Sugawara, T. Koike, R. Lopez, T. J. Gibson, D. G. Higgins, and J. D. Thompson. 2003. Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res. 31 : 3497-3500.","journal-title":"Nucleic Acids Res."},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"7973","DOI":"10.1073\/pnas.93.15.7973","volume":"93","year":"1996","unstructured":"Cox, D. L., D. R. Akins, K. W. Bourell, P. Lahdenne, M. V. Norgard, and J. D. Radolf. 1996. Limited surface exposure of Borrelia burgdorferi outer surface lipoproteins. Proc. Natl. Acad. Sci. USA 93 : 7973-7978.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1099\/00221287-147-5-1161","volume":"147","year":"2001","unstructured":"Cox, D. L., and J. D. Radolf. 2001. Insertion of fluorescent fatty acid probes into the outer membranes of the pathogenic spirochaetes Treponema pallidum and Borrelia burgdorferi. Microbiology 147 : 1161-1169.","journal-title":"Microbiology"},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.femsre.2003.10.004","volume":"28","year":"2004","unstructured":"Cullen, P. A., D. A. Haake, and B. Adler. 2004. Outer membrane proteins of pathogenic spirochetes. FEMS Microbiol. Rev. 28 : 291-318.","journal-title":"FEMS Microbiol. Rev."},{"key":"e_1_3_2_31_2","first-page":"1","volume":"4","year":"2002","unstructured":"Delcour, A. H. 2002. Structure and function of pore-forming beta-barrels from bacteria. J. Mol. Microbiol. Biotechnol. 4 : 1-10.","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0025-7125(03)00095-6","volume":"86","year":"2002","unstructured":"Dworkin, M. S., T. G. Schwan, and D. E. Anderson, Jr. 2002. Tick-borne relapsing fever in North America. Med. Clin. N. Am. 86 : 417-433.","journal-title":"Med. Clin. N. Am."},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/elps.11501401133","volume":"14","year":"1993","unstructured":"Eckerskorn, C., and F. Lottspeich. 1993. Structural characterization of blotting membranes and the influence of membrane parameters for electroblotting and subsequent amino acid sequence analysis of proteins. Electrophoresis 14 : 831-838.","journal-title":"Electrophoresis"},{"key":"e_1_3_2_34_2","unstructured":"Borrelia: strains vectors human and animal Borreliosis. 1971"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.142.2.521-526.1980"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/37551"},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0014-5793(82)81209-X","volume":"145","year":"1982","unstructured":"Freitag, H., G. Genchi, R. Benz, F. Palmieri, and W. Neupert. 1982. Isolation of mitochondrial porin from Neurospora crassa. FEBS Lett. 145 : 72-76.","journal-title":"FEBS Lett."},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1001\/jama.1969.03160040098019","volume":"208","year":"1969","unstructured":"Fuchs, P. C., and A. A. Oyama. 1969. Neonatal relapsing fever due to transplacental transmission of Borrelia. JAMA 208 : 690-692.","journal-title":"JAMA"},{"key":"e_1_3_2_39_2","first-page":"335","volume":"64","year":"1984","unstructured":"Goubau, P. F. 1984. Relapsing fevers. A review. Ann. Soc. Belg. Med. Trop. 64 : 335-364.","journal-title":"A review. Ann. Soc. Belg. Med. Trop."},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/jcc.10386","volume":"25","year":"2004","unstructured":"Gromiha, M. M., S. Ahmad, and M. Suwa. 2004. Neural network-based prediction of transmembrane beta-strand segments in outer membrane proteins. J. Comput. Chem. 25 : 762-767.","journal-title":"J. Comput. Chem."},{"key":"e_1_3_2_41_2","first-page":"727","volume":"50","year":"2005","unstructured":"Guggenheim, J. N., and A. D. Haverkamp. 2005. Tick-borne relapsing fever during pregnancy: a case report. J. Reprod. Med. 50 : 727-729.","journal-title":"J. Reprod. Med."},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0005-2736(86)90569-9","volume":"860","year":"1986","unstructured":"Hancock, R. E., and R. Benz. 1986. Demonstration and chemical modification of a specific phosphate binding site in the phosphate-starvation-inducible outer membrane porin protein P of Pseudomonas aeruginosa. Biochim. Biophys. Acta 860 : 699-707.","journal-title":"Biochim. Biophys. Acta"},{"key":"e_1_3_2_43_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.mi.31.100177.000513","volume":"31","year":"1977","unstructured":"Johnson, R. C. 1977. The spirochetes. Annu. Rev. Microbiol. 31 : 89-106.","journal-title":"Annu. Rev. Microbiol."},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_3_2_45_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1432-1033.1989.tb15209.x","volume":"186","year":"1989","unstructured":"Lakey, J. H., and F. Pattus. 1989. The voltage-dependent activity of Escherichia coli porins in different planar bilayer reconstitutions. Eur. J. Biochem. 186 : 303-308.","journal-title":"Eur. J. Biochem."},{"key":"e_1_3_2_46_2","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/0005-2736(86)90523-7","volume":"860","year":"1986","unstructured":"Ludwig, O., V. De Pinto, F. Palmieri, and R. Benz. 1986. Pore formation by the mitochondrial porin of rat brain in lipid bilayer membranes. Biochim. Biophys. Acta 860 : 268-276.","journal-title":"Biochim. Biophys. Acta"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/159.1.43"},{"key":"e_1_3_2_48_2","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/S0021-9258(18)69233-6","volume":"263","year":"1988","unstructured":"Maier, C., E. Bremer, A. Schmid, and R. Benz. 1988. Pore-forming activity of the Tsx protein from the outer membrane of Escherichia coli. Demonstration of a nucleoside-specific binding site. J. Biol. Chem. 263 : 2493-2499.","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_49_2","first-page":"A205","volume":"70","year":"1996","unstructured":"Mirzabekov, T. A., J. T. Skare, E. S. Shang, D. R. Blanco, J. N. Miller, M. A. Lovett, and B. L. Kagan. 1996. Electrical properties of porins from Borrelia burgdorferi. Biophys. J. 70 : A205.","journal-title":"Biophys. J."},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01239-06"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.67.4.593-656.2003"},{"key":"e_1_3_2_52_2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1044-0305(01)00365-8","volume":"13","year":"2002","unstructured":"Nilsson, C. L., H. J. Cooper, K. Hakansson, A. G. Marshall, Y. \u00d6stberg, M. Lavrinovicha, and S. Bergstr\u00f6m. 2002. Characterization of the P13 membrane protein of Borrelia burgdorferi by mass spectrometry. J. Am. Soc. Mass Spectrom. 13 : 295-299.","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.5.3323-3334.2001"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.24.6811-6819.2002"},{"key":"e_1_3_2_55_2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/BF01108409","volume":"25","year":"1993","unstructured":"Palmieri, F., C. Indiveri, F. Bisaccia, and R. Kramer. 1993. Functional properties of purified and reconstituted mitochondrial metabolite carriers. J. Bioenerg. Biomembr. 25 : 525-535.","journal-title":"J. Bioenerg. Biomembr."},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.1.21-31.1994"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.6.2154-2163.1995"},{"key":"e_1_3_2_58_2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s002320001065","volume":"175","year":"2000","unstructured":"Saier, M. H., Jr. 2000. Families of proteins forming transmembrane channels. J. Membr. Biol. 175 : 165-180.","journal-title":"J. Membr. Biol."},{"key":"e_1_3_2_59_2","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0923-2508(91)90085-O","volume":"142","year":"1991","unstructured":"Saint Girons, I., and A. G. Barbour. 1991. Antigenic variation in Borrelia. Res. Microbiol. 142 : 711-717.","journal-title":"Res. Microbiol."},{"key":"e_1_3_2_60_2","doi-asserted-by":"crossref","first-page":"16107","DOI":"10.1074\/jbc.274.23.16107","volume":"274","year":"1999","unstructured":"Sallmann, F. R., S. Baveye-Descamps, F. Pattus, V. Salmon, N. Branza, G. Spik, and D. Legrand. 1999. Porins OmpC and PhoE of Escherichia coli as specific cell-surface targets of human lactoferrin. Binding characteristics and biological effects. J. Biol. Chem. 274 : 16107-16114.","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_61_2","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1126\/science.280.5371.1938","volume":"280","year":"1998","unstructured":"Schwan, T. G., and B. J. Hinnebusch. 1998. Bloodstream- versus tick-associated variants of a relapsing fever bacterium. Science 280 : 1938-1940.","journal-title":"Science"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.8.3851-3859.2005"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1303.060958"},{"key":"e_1_3_2_64_2","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S0021-9258(19)57283-0","volume":"263","year":"1988","unstructured":"Sen, K., J. Hellman, and H. Nikaido. 1988. Porin channels in intact cells of Escherichia coli are not affected by Donnan potentials across the outer membrane. J. Biol. Chem. 263 : 1182-1187.","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.3.1082-1091.1998"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.16.4909-4918.1996"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.9.3654-3661.1997"},{"key":"e_1_3_2_68_2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00005792-196903000-00002","volume":"48","year":"1969","unstructured":"Southern, P., and J. Sanford. 1969. Relapsing fever: a clinical and microbiological review. Medicine 48 : 129-149.","journal-title":"Medicine"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.156.5.1297"},{"key":"e_1_3_2_70_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1348-0421.2006.tb03797.x","volume":"50","year":"2006","unstructured":"Tabuchi, N., K. Tomoda, H. Kawaguchi, H. Iwamoto, and M. Fukunaga. 2006. Immunodominant epitope in the C-terminus of a variable major protein in Borrelia duttonii, an agent of tick-borne relapsing fever. Microbiol. Immunol. 50 : 293-305.","journal-title":"Microbiol. Immunol."},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.55.9.2311-2313.1987"},{"key":"e_1_3_2_72_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/004947559702700229","volume":"27","year":"1997","unstructured":"van Holten, J., J. Tiems, and V. H. Jongen. 1997. Neonatal Borrelia duttoni infection: a report of three cases. Trop. Doct. 27 : 115-116.","journal-title":"Trop. Doct."},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68968-X"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.17.5585-5588.1991"},{"key":"e_1_3_2_75_2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0003-2697(84)90782-6","volume":"138","year":"1984","unstructured":"Wessel, D., and U. I. Fl\u00fcgge. 1984. A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal. Biochem. 138 : 141-143.","journal-title":"Anal. Biochem."},{"key":"e_1_3_2_76_2","first-page":"370","volume":"5","year":"1998","unstructured":"Yu, S., H. Ding, J. Seah, K. Wu, Y. Chang, K. S. Chang, M. F. Tam, and W. Syu. 1998. Characterization of a phage specific to hemorrhagic Escherichia coli O157:H7 and disclosure of variations in host outer membrane protein ompC. J. Biomed Sci. 5 : 370-382.","journal-title":"J. Biomed Sci."}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.00818-08","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.00818-08","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T17:42:30Z","timestamp":1627580550000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JB.00818-08"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":75,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1128\/JB.00818-08"],"URL":"https:\/\/doi.org\/10.1128\/jb.00818-08","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"2008-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}