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A functional two-partner secretion (TPS) system in\n            <jats:italic>N. meningitidis<\/jats:italic>\n            , composed of the secreted effector protein HrpA and its cognate transporter HrpB, is identified and characterized in this study. Although all meningococcal strains harbor at least one TPS system, the\n            <jats:italic>hrpA<\/jats:italic>\n            genes display significant C-terminal sequence variation. Meningococcal genes encoding the TPS effector proteins and their transporters are closely associated and transcribed into a single mRNA. HrpA proteins are translocated across the meningococcal outer membrane by their cognate transporters HrpB and mainly released into the environment. During this process, HrpA is proteolytically processed to a mature 180-kDa form. In contrast to other known TPS systems, immature HrpA proteins are stable in the absence of HrpB and accumulate within the bacterial cell. A small percentage of mature HrpA remains associated with the bacteria and contributes to the interaction of meningococci with epithelial cells.\n          <\/jats:p>","DOI":"10.1128\/jb.00851-07","type":"journal-article","created":{"date-parts":[[2007,9,15]],"date-time":"2007-09-15T00:59:03Z","timestamp":1189817943000},"page":"7968-7976","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":62,"title":["A Functional Two-Partner Secretion System Contributes to Adhesion of\n            <i>Neisseria meningitidis<\/i>\n            to Epithelial Cells"],"prefix":"10.1128","volume":"189","author":[{"given":"Corinna","family":"Schmitt","sequence":"first","affiliation":[{"name":"University of Wuerzburg, Institute of Hygiene and Microbiology, Josef-Schneider-Str. 2, E1, 97080 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Turner","sequence":"additional","affiliation":[{"name":"Institute of Infections, Immunity and Inflammation, School of Molecular Medical Sciences, Centre for Biomolecular Sciences, University Park, University of Nottingham, Nottingham NG7 2RD, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Boesl","sequence":"additional","affiliation":[{"name":"University of Wuerzburg, Institute of Hygiene and Microbiology, Josef-Schneider-Str. 2, E1, 97080 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Abele","sequence":"additional","affiliation":[{"name":"University of Wuerzburg, Institute of Hygiene and Microbiology, Josef-Schneider-Str. 2, E1, 97080 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Frosch","sequence":"additional","affiliation":[{"name":"University of Wuerzburg, Institute of Hygiene and Microbiology, Josef-Schneider-Str. 2, E1, 97080 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Kurzai","sequence":"additional","affiliation":[{"name":"University of Wuerzburg, Institute of Hygiene and Microbiology, Josef-Schneider-Str. 2, E1, 97080 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1046\/j.1365-2958.2000.02061.x","volume":"37","year":"2000","unstructured":"Ait-Tahar, K., K. 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