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Here, we show that with respect to their susceptibility to these respiratory inhibitors, staphylococcal species can be divided into two groups: the sensitive group, comprised of pathogenic species such as\n            <jats:italic>S. aureus<\/jats:italic>\n            and\n            <jats:italic>S. epidermidis<\/jats:italic>\n            , and the resistant group, represented by nonpathogenic species such as\n            <jats:italic>S. carnosus<\/jats:italic>\n            ,\n            <jats:italic>S. piscifermentans<\/jats:italic>\n            , and\n            <jats:italic>S. gallinarum<\/jats:italic>\n            . The resistance in the latter group of species was due to\n            <jats:italic>cydAB<\/jats:italic>\n            genes that encode a pyocyanin- and cyanide-insensitive cytochrome\n            <jats:italic>bd<\/jats:italic>\n            quinol oxidase. By exchanging\n            <jats:italic>cydB<\/jats:italic>\n            in\n            <jats:italic>S. aureus<\/jats:italic>\n            with the\n            <jats:italic>S. carnosus<\/jats:italic>\n            -specific\n            <jats:italic>cydB<\/jats:italic>\n            , we could demonstrate that CydB determines resistance. The resistant or sensitive phenotype was based on structural alterations in CydB, which is part of CydAB, the cytochrome\n            <jats:italic>bd<\/jats:italic>\n            quinol oxidase. CydB represents a prime example of both microevolution and the asymmetric pattern of evolutionary change.\n          <\/jats:p>","DOI":"10.1128\/jb.00858-06","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T03:29:02Z","timestamp":1163647742000},"page":"8079-8086","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":132,"title":["Microevolution of Cytochrome\n            <i>bd<\/i>\n            Oxidase in Staphylococci and Its Implication in Resistance to Respiratory Toxins Released by\n            <i>Pseudomonas<\/i>"],"prefix":"10.1128","volume":"188","author":[{"given":"Lalitha","family":"Voggu","sequence":"first","affiliation":[{"name":"Microbial Genetics, University of Tu\u0308bingen, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Schlag","sequence":"additional","affiliation":[{"name":"Microbial Genetics, University of Tu\u0308bingen, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Biswas","sequence":"additional","affiliation":[{"name":"Microbial Genetics, University of Tu\u0308bingen, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Rosenstein","sequence":"additional","affiliation":[{"name":"Microbial Genetics, University of Tu\u0308bingen, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Rausch","sequence":"additional","affiliation":[{"name":"Algorithms in Bioinformatics, Wilhelm Schickard Institut fu\u0308r Informatik, Eberhard Karls Universita\u0308t Tu\u0308bingen, Sand 14, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Go\u0308tz","sequence":"additional","affiliation":[{"name":"Microbial Genetics, University of Tu\u0308bingen, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/BF00425408","volume":"138","year":"1984","unstructured":"Akimenko, V. 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