{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:54:54Z","timestamp":1792673694575,"version":"4.5.0"},"reference-count":65,"publisher":"American Society for Microbiology","issue":"23","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Zinc is a bivalent cation essential for bacterial growth and metabolism. The human pathogen\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Neisseria meningitidis<\/jats:named-content>\n            expresses a homologue of the Zinc uptake regulator Zur, which has been postulated to repress the putative zinc uptake protein ZnuD. In this study, we elucidated the transcriptome of meningococci in response to zinc by microarrays and quantitative real-time PCR (qRT-PCR). We identified 15 genes that were repressed and two genes that were activated upon zinc addition. All transcription units (genes and operons) harbored a putative Zur binding motif in their promoter regions. A meningococcal Zur binding consensus motif (Zur box) was deduced\n            <jats:italic>in silico<\/jats:italic>\n            , which harbors a conserved central palindrome consisting of hexameric inverted repeats separated by three nucleotides (TGTTAT\n            <jats:underline>DNH<\/jats:underline>\n            ATAACA).\n            <jats:italic>In vitro<\/jats:italic>\n            binding of recombinant meningococcal Zur to this Zur box was shown for the first time using electrophoretic mobility shift assays. Zur binding to DNA depended specifically on the presence of zinc and was sensitive to mutations in the palindromic sequence. The Zur regulon among genes of unknown function comprised genes involved in zinc uptake, tRNA modification, and ribosomal assembly. In summary, this is the first study of the transcriptional response to zinc in meningococci.\n          <\/jats:p>","DOI":"10.1128\/jb.01091-12","type":"journal-article","created":{"date-parts":[[2012,10,6]],"date-time":"2012-10-06T05:55:38Z","timestamp":1349502938000},"page":"6594-6603","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["The Zinc-Responsive Regulon of Neisseria meningitidis Comprises 17 Genes under Control of a Zur Element"],"prefix":"10.1128","volume":"194","author":[{"given":"Marie-Christin","family":"Pawlik","sequence":"first","affiliation":[{"name":"University of W\u00fcrzburg, Institute for Hygiene and Microbiology, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Hubert","sequence":"additional","affiliation":[{"name":"University of W\u00fcrzburg, Institute for Hygiene and Microbiology, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biju","family":"Joseph","sequence":"additional","affiliation":[{"name":"University of W\u00fcrzburg, Institute for Hygiene and Microbiology, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Claus","sequence":"additional","affiliation":[{"name":"University of W\u00fcrzburg, Institute for Hygiene and Microbiology, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schoen","sequence":"additional","affiliation":[{"name":"University of W\u00fcrzburg, Institute for Hygiene and Microbiology, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Vogel","sequence":"additional","affiliation":[{"name":"University of W\u00fcrzburg, Institute for Hygiene and Microbiology, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1093\/ajcn\/33.6.1314","article-title":"Zinc transport by lactoferrin in human milk","volume":"33","author":"Ainscough EW","year":"1980","unstructured":"AinscoughEWBrodieAMPlowmanJE. 1980. 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