{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:43:19Z","timestamp":1768686199392,"version":"3.49.0"},"reference-count":108,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2011,1,15]],"date-time":"2011-01-15T00:00:00Z","timestamp":1295049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2011,1,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            causes several diseases, including pneumonia, septicemia, and meningitis. Phage Dp-1 is one of the very few isolated virulent\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            bacteriophages, but only a partial characterization is currently available. Here, we confirmed that Dp-1 belongs to the family\n            <jats:italic>Siphoviridae<\/jats:italic>\n            . Then, we determined its complete genomic sequence of 56,506 bp. It encodes 72 open reading frames, of which 44 have been assigned a function. We have identified putative promoters, Rho-independent terminators, and several genomic clusters. We provide evidence that Dp-1 may be using a novel DNA replication system as well as redirecting host protein synthesis through queuosine-containing tRNAs. Liquid chromatography-mass spectrometry analysis of purified phage Dp-1 particles identified at least eight structural proteins. Finally, using comprehensive yeast two-hybrid screens, we identified 156 phage protein interactions, and this intraviral interactome was used to propose a structural model of Dp-1.\n          <\/jats:p>","DOI":"10.1128\/jb.01117-10","type":"journal-article","created":{"date-parts":[[2010,11,20]],"date-time":"2010-11-20T03:54:22Z","timestamp":1290225262000},"page":"551-562","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":51,"title":["Genome Annotation and Intraviral Interactome for the\n            <i>Streptococcus pneumoniae<\/i>\n            Virulent Phage Dp-1"],"prefix":"10.1128","volume":"193","author":[{"given":"Mourad","family":"Sabri","sequence":"first","affiliation":[{"name":"De\u0301partement de Biochimie, de Microbiologie et Bio-Informatiques, Faculte\u0301 des Sciences et de Ge\u0301nie, Groupe de Recherche en E\u0301cologie Buccale, Faculte\u0301 de Me\u0301decine Dentaire, Fe\u0301lix d'He\u0301relle Reference Center for Bacterial Viruses, Universite\u0301 Laval, Que\u0301bec, Canada G1V 0A6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Ha\u0308user","sequence":"additional","affiliation":[{"name":"Institute of Toxicology and Genetics, Karlsruhe Institute for Technology, Karlsruhe, Germany"},{"name":"J. Craig Venter Institute, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Ouellette","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Infectiologie de l'Universite\u0301 Laval, Centre Hospitalier Universitaire de Que\u0301bec, Que\u0301bec, Canada G1V 4G2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"The Medicines Company, Ville St. Laurent, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Dehbi","sequence":"additional","affiliation":[{"name":"The Medicines Company, Ville St. Laurent, Quebec, Canada"},{"name":"Present address: Biochemistry &amp; Molecular Biology Unit, Dasman Diabetes Institute, Dasman, Kuwait."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Moeck","sequence":"additional","affiliation":[{"name":"The Medicines Company, Ville St. Laurent, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Garci\u0301a","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biolo\u0301gicas, CSIC, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjo\u0308rn","family":"Titz","sequence":"additional","affiliation":[{"name":"Crump Institute for Molecular Imaging, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Uetz","sequence":"additional","affiliation":[{"name":"J. Craig Venter Institute, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Moineau","sequence":"additional","affiliation":[{"name":"De\u0301partement de Biochimie, de Microbiologie et Bio-Informatiques, Faculte\u0301 des Sciences et de Ge\u0301nie, Groupe de Recherche en E\u0301cologie Buccale, Faculte\u0301 de Me\u0301decine Dentaire, Fe\u0301lix d'He\u0301relle Reference Center for Bacterial Viruses, Universite\u0301 Laval, Que\u0301bec, Canada G1V 0A6"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(98)01298-5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh131"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(98)01293-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1099\/0022-1317-32-2-249","volume":"32","year":"1976","unstructured":"Bamford, D. H., E. T. Palva, and K. Lounatmaa. 1976. Ultrastructure and life cycle of the lipid-containing bacteriophage \u03c66. J. Gen. Virol. 32:249-259.","journal-title":"J. Gen. Virol."},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1099\/0022-1317-57-2-365","volume":"57","year":"1981","unstructured":"Bamford, D. H., L. Rouhiainen, K. Takkinen, and H. S\u00f6derlund. 1981. Comparison of the lipid-containing bacteriophages PRD1, PR3, PR4, PR5 and L17. J. Gen. Virol. 57:365-373.","journal-title":"J. Gen. Virol."},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/ng0196-72","volume":"12","year":"1996","unstructured":"Bartel, P. L., J. A. Roecklein, D. SenGupta, and S. Fields. 1996. A protein linkage map of Escherichia coli bacteriophage T7. Nat. Genet. 12:72-77.","journal-title":"Nat. Genet."},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.12565","volume":"195","year":"1977","unstructured":"Bernheimer, H. P. 1977. Lysogeny in pneumococci freshly isolated from man. Science 195:66-68.","journal-title":"Science"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0042-6822(76)90085-4","volume":"73","year":"1976","unstructured":"Bernheimer, H. P., and J.-G. Tiraby. 1976. Inhibition of phage infection by pneumococcus capsule. Virology 73:308-309.","journal-title":"Virology"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi0405s01"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.034116-0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(00)28386-9"},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1086\/653123","volume":"202","year":"2010","unstructured":"Calix, J. J., and M. H. Nahm. 2010. A new pneumococcal serotype, 11E, has a variably inactivated wcjE gene. J. Infect. Dis. 202:29-38.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_3_15_2","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nmeth0910-667","volume":"7","year":"2010","unstructured":"Chen, Y.-C., S. V. Rajagopala, T. Stellberger, and P. Uetz. 2010. Exhaustive benchmarking of the yeast two-hybrid system. Nat. Methods 7:667-668.","journal-title":"Nat. Methods"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01718.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.resmic.2008.05.001","volume":"159","year":"2008","unstructured":"Comeau, A. M., et al. 2008. Exploring the prokaryotic virosphere. Res. Microbiol. 159:306-313.","journal-title":"Res. Microbiol."},{"key":"e_1_3_3_18_2","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S1097-2765(02)00537-3","volume":"9","year":"2002","unstructured":"de Beer, T., et al. 2002. Insights into specific DNA recognition during the assembly of a viral genome packaging machine. Mol. Cell 9:981-991.","journal-title":"Mol. Cell"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00241-09"},{"key":"e_1_3_3_20_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/prep.2001.1602","volume":"25","year":"2002","unstructured":"Dieckman, L., M. Gu, L. Stols, M. I. Donnelly, and F. R. Collart. 2002. High throughput methods for gene cloning and expression. Protein Expr. Purif. 25:1-7.","journal-title":"Protein Expr. Purif."},{"key":"e_1_3_3_21_2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jsb.2006.08.009","volume":"157","year":"2007","unstructured":"Doan, D. N. P., and T. Dokland. 2007. The gpQ portal protein of bacteriophage P2 forms dodecameric connectors in crystals. J. Struct. Biol. 157:432-436.","journal-title":"J. Struct. Biol."},{"key":"e_1_3_3_22_2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1006\/jmbi.1999.3449","volume":"296","year":"2000","unstructured":"Dr\u00f6ge, A., and P. Tavares. 2000. In vitro packaging of DNA of the Bacillus subtilis bacteriophage SPP1. J. Mol. Biol. 296:103-115.","journal-title":"J. Mol. Biol."},{"key":"e_1_3_3_23_2","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.1073\/pnas.0400444101","volume":"101","year":"2004","unstructured":"Fokine, A., et al. 2004. Molecular architecture of the prolate head of bacteriophage T4. Proc. Natl. Acad. Sci. U. S. A. 101:6003-6008.","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"e_1_3_3_24_2","doi-asserted-by":"crossref","first-page":"e1000570","DOI":"10.1371\/journal.ppat.1000570","volume":"5","year":"2009","unstructured":"Fossum, E., et al. 2009. Evolutionarily conserved herpesviral protein interaction networks. PLoS Pathog. 5:e1000570.","journal-title":"PLoS Pathog."},{"key":"e_1_3_3_25_2","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0042-6822(69)90182-2","volume":"38","year":"1969","unstructured":"Franklin, R. M., M. Salditt, and J. A. Silbert. 1969. Structure and synthesis of a lipid-containing bacteriophage. I. Growth of bacteriophage PM2 and alterations in nucleic acid metabolism in the infected cell. Virology 38:627-640.","journal-title":"Virology"},{"key":"e_1_3_3_26_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1471-2105-9-79","volume":"9","year":"2008","unstructured":"Gao, F., and C.-T. Zhang. 2008. Ori-Finder: a web-based system for finding oriCs in unannotated bacterial genomes. BMC Bioinformatics 9:79.","journal-title":"BMC Bioinformatics"},{"key":"e_1_3_3_27_2","first-page":"335","year":"2005","unstructured":"Garc\u00eda, P., J. L. Garc\u00eda, R. L\u00f3pez, and E. Garc\u00eda. 2005. Pneumococcal phages, p. 335-361. In M. K. Waldor, D. L. I. Friedman, and S. Adhya (ed.), Phages: their role in bacterial pathogenesis and biotechnology. ASM Press, Washington, DC.","journal-title":"Phages: their role in bacterial pathogenesis and biotechnology"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.159.2.793-796.1984"},{"key":"e_1_3_3_29_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2478\/v10136-009-0016-6","volume":"8","year":"2010","unstructured":"Garc\u00eda, P., M. Moscoso, V. Rodr\u00edguez-Cerrato, J. Yuste, and E. Garc\u00eda. 2010. Streptococcus pneumoniae: from molecular biology to host-pathogen interactions. J. Appl. Biomed. 8:131-140.","journal-title":"J. Appl. Biomed."},{"key":"e_1_3_3_30_2","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1073\/pnas.56.4.1226","volume":"56","year":"1966","unstructured":"Greenberg, G. R. 1966. New dUTPase and dUDPase activites after infection of Escherichia coli by T2 bacteriophage. Proc. Natl. Acad. Sci. U. S. A. 56:1226-1232.","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2005.06.005"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90499-G"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2008.09.004"},{"key":"e_1_3_3_34_2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.mib.2007.08.002","volume":"10","year":"2007","unstructured":"Hermoso, J. A., J. L. Garc\u00eda, and P. Garc\u00eda. 2007. Taking aim on bacterial pathogens: from phage therapy to enzybiotics. Curr. Opin. Microbiol. 10:461-472.","journal-title":"Curr. Opin. Microbiol."},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1086\/521626"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(65)90093-7"},{"key":"e_1_3_3_37_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0042-6822(78)90351-3","volume":"91","year":"1978","unstructured":"Hsiao, C. L., and L. W. Black. 1978. Head morphogenesis of bacteriophage T4. II. The role of gene 40 in initiating prehead assembly. Virology 91:15-25.","journal-title":"Virology"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.02.012"},{"key":"e_1_3_3_39_2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.cbpa.2008.01.041","volume":"12","year":"2008","unstructured":"Iwata-Reuyl, D. 2008. An embarrassment of riches: the enzymology of RNA modification. Curr. Opin. Chem. Biol. 12:126-133.","journal-title":"Curr. Opin. Chem. Biol."},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg485"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-45-2-406"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.18.3.1000-1015.1976"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.5.2327-2333.1999"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00850-06"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01148-06"},{"key":"e_1_3_3_47_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2105-4-21","volume":"4","year":"2003","unstructured":"Larsen, T. S., and A. Krogh. 2003. EasyGene\u2014a prokaryotic gene finder that ranks ORFs by statistical significance. BMC Bioinformatics 4:21.","journal-title":"BMC Bioinformatics"},{"key":"e_1_3_3_48_2","first-page":"D57","volume":"38","year":"2009","unstructured":"Leplae, R., G. Lima-Mendez, and A. Toussaint. 2009. ACLAME: A CLAssification of Mobile genetic Elements, update 2010. Nucleic Acids Res. 38:D57-D61.","journal-title":"Nucleic Acids Res."},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.17.3583"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn808"},{"key":"e_1_3_3_51_2","doi-asserted-by":"crossref","first-page":"8507","DOI":"10.1073\/pnas.0812407106","volume":"106","year":"2009","unstructured":"Lhuillier, S., et al. 2009. Structure of bacteriophage SPP1 head-to-tail connection reveals mechanism for viral DNA gating. Proc. Natl. Acad. Sci. U. S. A. 106:8507-8512.","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00020-06"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.1.375-377.2003"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1066869"},{"key":"e_1_3_3_55_2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ddstr.2004.09.002","volume":"1","year":"2004","unstructured":"L\u00f3pez, R., E. Garc\u00eda, and P. Garc\u00eda. 2004. Enzymes for anti-infective therapy: phage lysins. Drug Discov. Today Ther. Strateg. 1:469-474.","journal-title":"Drug Discov. Today Ther. Strateg."},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.151.3.1581-1590.1982"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.24.1.201-210.1977"},{"key":"e_1_3_3_58_2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0022-2836(71)90109-4","volume":"57","year":"1971","unstructured":"Luftig, R. B., W. B. Wood, and R. Okinaka. 1971. Bacteriophage T4 head morphogenesis. On the nature of gene 49-defective heads and their role as intermediates. J. Mol. Biol. 57:555-558.","journal-title":"J. Mol. Biol."},{"key":"e_1_3_3_59_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0022-2836(02)00298-X","volume":"319","year":"2002","unstructured":"Malys, N., D.-Y. Chang, R. G. Baumann, D. Xie, and L. W. Black. 2002. A bipartite bacteriophage T4 SOC and HOC randomized peptide display library: detection and analysis of phage T4 terminase (gp17) and late \u03c3 factor (gp55) interaction. J. Mol. Biol. 319:289-304.","journal-title":"J. Mol. Biol."},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh454"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.6.3678-3687.1996"},{"key":"e_1_3_3_62_2","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jmb.2005.06.064","volume":"351","year":"2005","unstructured":"Mart\u00ednez-Jim\u00e9nez, M. I., J. C. Alonso, and S. Ayora. 2005. Bacillus subtilis bacteriophage SPP1-encoded gene 34.1 product is a recombination-dependent DNA replication protein. J. Mol. Biol. 351:1007-1019.","journal-title":"J. Mol. Biol."},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065103"},{"key":"e_1_3_3_64_2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0042-6822(75)90329-3","volume":"63","year":"1975","unstructured":"McDonnell, M., C. Ronda-La\u00edn, and A. Tomasz. 1975. \u201cDiplophage\u201d: a bacteriophage of Diplococcus pneumoniae. Virology 63:577-582.","journal-title":"Virology"},{"key":"e_1_3_3_65_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1006\/mgme.2001.3216","volume":"74","year":"2001","unstructured":"Morris, R. C., and M. S. Elliott. 2001. Queuosine modification of tRNA: a case for convergent evolution. Mol. Genet. Metab. 74:147-159.","journal-title":"Mol. Genet. Metab."},{"key":"e_1_3_3_66_2","doi-asserted-by":"crossref","first-page":"8306","DOI":"10.1073\/pnas.131007398","volume":"98","year":"2001","unstructured":"Mosig, G., J. Gewin, A. Luder, N. Colowick, and D. Vo. 2001. Two recombination-dependent DNA replication pathways of bacteriophage T4, and their roles in mutagenesis and horizontal gene transfer. Proc. Natl. Acad. Sci. U. S. A. 98:8306-8311.","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-515-2_5"},{"key":"e_1_3_3_68_2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/jac\/dki177","volume":"56","year":"2005","unstructured":"Mushtaq, N., M. B. Redpath, J. P. Luzio, and P. W. Taylor. 2005. Treatment of experimental Escherichia coli infection with recombinant bacteriophage-derived capsule depolymerase. J. Antimicrob. Chemother. 56:160-165.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.7.2362-2368.2003"},{"key":"e_1_3_3_70_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1089\/107662903764736292","volume":"9","year":"2003","unstructured":"Obreg\u00f3n, V., P. Garc\u00eda, R. L\u00f3pez, and J. L. Garc\u00eda. 2003. VO1, a temperate bacteriophage of the type 19A multiresistant epidemic 8249 strain of Streptococcus pneumoniae: analysis of variability of lytic and putative C5 methyltransferase genes. Microb. Drug Resist. 9:7-15.","journal-title":"Microb. Drug Resist."},{"key":"e_1_3_3_71_2","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/12303","volume":"6","year":"1999","unstructured":"Orlova, E. V., et al. 1999. Structure of the 13-fold symmetric portal protein of bacteriophage SPP1. Nat. Struct. Mol. Biol. 6:842-846.","journal-title":"Nat. Struct. Mol. Biol."},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-7-r130"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi0309s04"},{"key":"e_1_3_3_74_2","unstructured":"Development of novel anti-microbial agents based on bacteriophage genomics. 2000"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2006.12.016"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.19.2.659-667.1976"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/35051615"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.12.3618-3625.1999"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.06082.x"},{"key":"e_1_3_3_80_2","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1111\/j.1469-0691.2009.02724.x","volume":"15","year":"2009","unstructured":"Reinert, R. R. 2009. The antimicrobial resistance profile of Streptococcus pneumoniae. Clin. Microbiol. Infect. 15:S7-S11.","journal-title":"Clin. Microbiol. Infect."},{"key":"e_1_3_3_81_2","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/jac\/dkm342","volume":"60","year":"2007","unstructured":"Rodr\u00edguez-Cerrato, V., et al. 2007. In vitro interactions of LytA, the major pneumococcal autolysin, with two bacteriophage lytic enzymes (Cpl-1 and Pal), cefotaxime and moxifloxacin against antibiotic-susceptible and -resistant Streptococcus pneumoniae strains. J. Antimicrob. Chemother. 60:1159-1162.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.64.10.5149-5155.1990"},{"key":"e_1_3_3_83_2","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1128\/AEM.02155-08","volume":"75","year":"2009","unstructured":"Romero, P., E. Garc\u00eda, and T. J. Mitchell. 2009. Development of a prophage typing system and analysis of prophage carriage in Streptococcus pneumoniae Appl. Environ. Microbiol. 75:1642-1649.","journal-title":"Environ. Microbiol."},{"key":"e_1_3_3_84_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.virol.2004.01.029","volume":"322","year":"2004","unstructured":"Romero, P., R. L\u00f3pez, and E. Garc\u00eda. 2004. Genomic organization and molecular analysis of the inducible prophage EJ-1, a mosaic myovirus from an atypical pneumococcus. Virology 322:239-252.","journal-title":"Virology"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.21.1.366-374.1977"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.40.2.551-559.1981"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1995.0366"},{"key":"e_1_3_3_88_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1261\/rna.7193705","volume":"11","year":"2005","unstructured":"Sawaya, R., B. Schwer, and S. Shuman. 2005. Structure-function analysis of the yeast NAD+-dependent tRNA 2\u2032-phosphotransferase Tpt1. RNA 11:107-113.","journal-title":"RNA"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki366"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00706-06"},{"key":"e_1_3_3_91_2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1046\/j.1365-2958.1997.5101880.x","volume":"25","year":"1997","unstructured":"Sheehan, M. M., J. L. Garc\u00eda, R. L\u00f3pez, and P. Garc\u00eda. 1997. The lytic enzyme of the pneumococcal phage Dp-1: a chimeric lysin of intergeneric origin. Mol. Microbiol. 25:717-725.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.16.1784"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01363-08"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061217"},{"key":"e_1_3_3_95_2","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/0042-6822(75)90300-1","volume":"68","year":"1975","unstructured":"Tiraby, J. G., E. Tiraby, and M. S. Fox. 1975. Pneumococcal bacteriophages. Virology 68:566-569.","journal-title":"Virology"},{"key":"e_1_3_3_96_2","doi-asserted-by":"crossref","first-page":"e2292","DOI":"10.1371\/journal.pone.0002292","volume":"3","year":"2008","unstructured":"Titz, B., et al. 2008. The binary protein interactome of Treponema pallidum\u2014the syphilis spirochete. PLoS One 3:e2292.","journal-title":"PLoS One"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1116804"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61114-4"},{"key":"e_1_3_3_99_2","doi-asserted-by":"crossref","first-page":"43697","DOI":"10.1074\/jbc.M407067200","volume":"279","year":"2004","unstructured":"Varea, J., et al. 2004. Structural and thermodynamic characterization of Pal, a phage natural chimeric lysin active against pneumococci. J. Biol. Chem. 279:43697-43707.","journal-title":"J. Biol. Chem."},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.11.5.799-805.1973"},{"key":"e_1_3_3_101_2","first-page":"135","volume":"30","year":"2009","unstructured":"Vinayak, M., and C. Pathak. 2009. Queuosine modification of tRNA: its divergent role in cellular machinery. Biosci. Rep. 30:135-148.","journal-title":"Biosci. Rep."},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26011-0"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2006.00015.x"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022823"},{"key":"e_1_3_3_105_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.mimet.2007.03.009","volume":"70","year":"2007","unstructured":"Williams, S. P., A. G. Tait-Kamradt, J. E. Norton, T. J. Albert, and T. J. Dougherty. 2007. Nucleotide sequence changes between Streptococcus pneumoniae R6 and D39 strains determined by an oligonucleotide hybridization DNA sequencing technology. J. Microbiol. Methods 70:65-74.","journal-title":"J. Microbiol. Methods"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi0813s23"},{"key":"e_1_3_3_107_2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0022-2836(81)90351-X","volume":"149","year":"1981","unstructured":"Zachary, A., and L. W. Black. 1981. DNA ligase is required for encapsidation of bacteriophage T4 DNA. J. Mol. Biol. 149:641-658.","journal-title":"J. Mol. Biol."},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.02.036"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg595"}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.01117-10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.01117-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T05:50:06Z","timestamp":1630734606000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JB.01117-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,15]]},"references-count":108,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,1,15]]}},"alternative-id":["10.1128\/JB.01117-10"],"URL":"https:\/\/doi.org\/10.1128\/jb.01117-10","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,15]]},"assertion":[{"value":"2010-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-11-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-01-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}