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The leptospiral life cycle involves transmission via freshwater and colonization of the renal tubules of their reservoir hosts. Infection requires adherence to cell surfaces and extracellular matrix components of host tissues. These host-pathogen interactions involve outer membrane proteins (OMPs) expressed on the bacterial surface. In this study, we developed an<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Leptospira interrogans<\/jats:named-content>serovar Copenhageni strain Fiocruz L1-130 OMP microarray containing all predicted lipoproteins and transmembrane OMPs. A total of 401 leptospiral genes or their fragments were transcribed and translated<jats:italic>in vitro<\/jats:italic>and printed on nitrocellulose-coated glass slides. We investigated the potential of this protein microarray to screen for interactions between leptospiral OMPs and fibronectin (Fn). This approach resulted in the identification of the recently described fibronectin-binding protein, LIC10258 (MFn8, Lsa66), and 14 novel Fn-binding proteins, denoted<jats:underline>M<\/jats:underline>icroarray<jats:underline>Fn<\/jats:underline>-binding proteins (MFns). We confirmed Fn binding of purified recombinant LIC11612 (MFn1), LIC10714 (MFn2), LIC11051 (MFn6), LIC11436 (MFn7), LIC10258 (MFn8, Lsa66), and LIC10537 (MFn9) by far-Western blot assays. Moreover, we obtained specific antibodies to MFn1, MFn7, MFn8 (Lsa66), and MFn9 and demonstrated that MFn1, MFn7, and MFn9 are expressed and surface exposed under<jats:italic>in vitro<\/jats:italic>growth conditions. Further, we demonstrated that MFn1, MFn4 (LIC12631, Sph2), and MFn7 enable leptospires to bind fibronectin when expressed in the saprophyte,<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Leptospira biflexa<\/jats:named-content>. Protein microarrays are valuable tools for high-throughput identification of novel host ligand-binding proteins that have the potential to play key roles in the virulence mechanisms of pathogens.<\/jats:p>","DOI":"10.1128\/jb.01119-12","type":"journal-article","created":{"date-parts":[[2012,9,8]],"date-time":"2012-09-08T04:02:48Z","timestamp":1347076968000},"page":"6074-6087","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":43,"title":["Leptospiral Outer Membrane Protein Microarray, a Novel Approach to Identification of Host Ligand-Binding Proteins"],"prefix":"10.1128","volume":"194","author":[{"given":"Marija","family":"Pinne","sequence":"first","affiliation":[{"name":"Research Service, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA"},{"name":"Departments of Medicine, University of California at Los Angeles, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Research Service, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA"},{"name":"Departments of Medicine, University of California at Los Angeles, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Haake","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA"},{"name":"Departments of Medicine, University of California at Los Angeles, Los Angeles, California, USA"},{"name":"Urology, The David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA"},{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.2041-1014.2011.00625.x","article-title":"OmpA-like protein influences cell shape and adhesive activity of Tannerella forsythia","volume":"26","author":"Abe T","year":"2011","unstructured":"AbeT. 2011. 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