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Transcriptome analysis revealed that growth of\n            <jats:italic>S. aureus<\/jats:italic>\n            with salicylate leads to the induction of genes involved with gluconate and formate metabolism and represses genes required for gluconeogenesis and glycolysis. In addition, salicylate induction upregulates two antibiotic target genes and downregulates a multidrug efflux pump gene repressor (\n            <jats:italic>mgrA<\/jats:italic>\n            ) and\n            <jats:italic>sarR<\/jats:italic>\n            , which represses a gene (\n            <jats:italic>sarA<\/jats:italic>\n            ) important for intrinsic antimicrobial resistance. We hypothesize that these salicylate-induced alterations jointly represent a unique mechanism that allows\n            <jats:italic>S. aureus<\/jats:italic>\n            to resist antimicrobial stress and toxicity.\n          <\/jats:p>","DOI":"10.1128\/jb.01149-06","type":"journal-article","created":{"date-parts":[[2006,12,16]],"date-time":"2006-12-16T00:30:00Z","timestamp":1166229000000},"page":"220-227","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["Response of\n            <i>Staphylococcus aureus<\/i>\n            to Salicylate Challenge"],"prefix":"10.1128","volume":"189","author":[{"given":"James T.","family":"Riordan","sequence":"first","affiliation":[{"name":"Microbiology Group, Department of Biology"},{"name":"Molecular Biology Program, New Mexico State University, Las Cruces, New Mexico 88003-8001"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arunachalam","family":"Muthaiyan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Illinois State University, Normal, Illinois 61791-4120"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne","family":"Van Voorhies","sequence":"additional","affiliation":[{"name":"Molecular Biology Program, New Mexico State University, Las Cruces, New Mexico 88003-8001"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher T.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, Kentucky 40292"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, Kentucky 40292"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Illinois State University, Normal, Illinois 61791-4120"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Gustafson","sequence":"additional","affiliation":[{"name":"Microbiology Group, Department of Biology"},{"name":"Molecular Biology Program, New Mexico State University, Las Cruces, New Mexico 88003-8001"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/90429","volume":"8","year":"2001","unstructured":"Alekshun, M. 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