{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:54:47Z","timestamp":1787637287251,"version":"build-2736575974"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"23","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The population genetic structure of the animal pathogen\n            <jats:italic>Staphylococcus intermedius<\/jats:italic>\n            is poorly understood. We carried out a multilocus sequence phylogenetic analysis of isolates from broad host and geographic origins to investigate inter- and intraspecies diversity. We found that isolates phenotypically identified as\n            <jats:italic>S. intermedius<\/jats:italic>\n            are differentiated into three closely related species,\n            <jats:italic>S. intermedius<\/jats:italic>\n            ,\n            <jats:italic>Staphylococcus pseudintermedius<\/jats:italic>\n            , and\n            <jats:italic>Staphylococcus delphini. S. pseudintermedius<\/jats:italic>\n            , not\n            <jats:italic>S. intermedius<\/jats:italic>\n            , is the common cause of canine pyoderma and occasionally causes zoonotic infections of humans. Over 60 extant STs were identified among the\n            <jats:italic>S. pseudintermedius<\/jats:italic>\n            isolates examined, including several that were distributed on different continents. As the\n            <jats:italic>agr<\/jats:italic>\n            quorum-sensing system of staphylococci is thought to have evolved along lines of speciation within the genus, we examined the allelic variation of\n            <jats:italic>agrD<\/jats:italic>\n            , which encodes the autoinducing peptide (AIP). Four AIP variants were encoded by\n            <jats:italic>S. pseudintermedius<\/jats:italic>\n            isolates, and identical AIP variants were shared among the three species, suggesting that a common quorum-sensing capacity has been conserved in spite of species differentiation in largely distinct ecological niches. A lack of clonal association of\n            <jats:italic>agr<\/jats:italic>\n            alleles suggests that assortive recombination may have contributed to the distribution of\n            <jats:italic>agr<\/jats:italic>\n            diversity. Finally, we discovered that the recent emergence of methicillin-resistant strains was due to multiple acquisitions of the\n            <jats:italic>mecA<\/jats:italic>\n            gene by different\n            <jats:italic>S. pseudintermedius<\/jats:italic>\n            clones found on different continents. Taken together, these data have resolved the population genetic structure of the\n            <jats:italic>S. intermedius<\/jats:italic>\n            group, resulting in new insights into its ancient and recent evolution.\n          <\/jats:p>","DOI":"10.1128\/jb.01150-07","type":"journal-article","created":{"date-parts":[[2007,9,29]],"date-time":"2007-09-29T01:05:03Z","timestamp":1191027903000},"page":"8685-8692","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":222,"title":["Population Genetic Structure of the\n            <i>Staphylococcus intermedius<\/i>\n            Group: Insights into\n            <i>agr<\/i>\n            Diversification and the Emergence of Methicillin-Resistant Strains"],"prefix":"10.1128","volume":"189","author":[{"given":"Jeanette","family":"Bannoehr","sequence":"first","affiliation":[{"name":"Centre for Infectious Diseases, Royal (Dick) School of Veterinary Studies, The Chancellor's Building, New Royal Infirmary, University of Edinburgh, Edinburgh EH16 4SB, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouri L.","family":"Ben Zakour","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases, Royal (Dick) School of Veterinary Studies, The Chancellor's Building, New Royal Infirmary, University of Edinburgh, Edinburgh EH16 4SB, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Waller","sequence":"additional","affiliation":[{"name":"Centre for Preventive Medicine, Animal Health Trust, Newmarket, Suffolk CB8 7UU,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Guardabassi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Faculty of Life Science, University of Copenhagen, Frederiksberg C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith L.","family":"Thoday","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Division of Veterinary Clinical Sciences, Royal (Dick) School of Veterinary Studies, Easter Bush Veterinary Centre, University of Edinburgh, Roslin, Midlothian, EH25 9RG, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri H. M.","family":"van den Broek","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Division of Veterinary Clinical Sciences, Royal (Dick) School of Veterinary Studies, Easter Bush Veterinary Centre, University of Edinburgh, Roslin, Midlothian, EH25 9RG, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Ross","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases, Royal (Dick) School of Veterinary Studies, The Chancellor's Building, New Royal Infirmary, University of Edinburgh, Edinburgh EH16 4SB, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1099\/00207713-51-4-1343","volume":"51","year":"2001","unstructured":"Aarestrup, F. M. 2001. 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