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To study its metabolism, we constructed a genome-scale metabolic model (\n                    <jats:italic>i<\/jats:italic>\n                    YL1228) for strain MGH 78578, experimentally determined its biomass composition, experimentally determined its ability to grow on a broad range of carbon, nitrogen, phosphorus and sulfur sources, and assessed the ability of the model to accurately simulate growth versus no growth on these substrates. The model contains 1,228 genes encoding 1,188 enzymes that catalyze 1,970 reactions and accurately simulates growth on 84% of the substrates tested. Furthermore, quantitative comparison of growth rates between the model and experimental data for nine of the substrates also showed good agreement. The genome-scale metabolic reconstruction for\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    presented here thus provides an experimentally validated\n                    <jats:italic>in silico<\/jats:italic>\n                    platform for further studies of this important industrial and biomedical organism.\n                  <\/jats:p>","DOI":"10.1128\/jb.01218-10","type":"journal-article","created":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T22:56:06Z","timestamp":1296860166000},"page":"1710-1717","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":131,"title":["An Experimentally Validated Genome-Scale Metabolic Reconstruction of\n                    <i>Klebsiella pneumoniae<\/i>\n                    MGH 78578,\n                    <i>i<\/i>\n                    YL1228"],"prefix":"10.1128","volume":"193","author":[{"given":"Yu-Chieh","family":"Liao","sequence":"first","affiliation":[{"name":"Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan 350, Taiwan"},{"name":"Department of Bioengineering, University of California\u2014San Diego, 9500 Gilman Dr., La Jolla, California 92093-0412"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Wen","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan 350, Taiwan"},{"name":"Department of Bioengineering, University of California\u2014San Diego, 9500 Gilman Dr., La Jolla, California 92093-0412"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan 350, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pep","family":"Charusanti","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of California\u2014San Diego, 9500 Gilman Dr., La Jolla, California 92093-0412"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay S. 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