{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:17:45Z","timestamp":1792624665323,"version":"4.5.0"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"24","license":[{"start":{"date-parts":[[2007,12,15]],"date-time":"2007-12-15T00:00:00Z","timestamp":1197676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2007,12,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Burkholderia pseudomallei<\/jats:italic>\n            is the etiologic agent of melioidosis. Many disease manifestations are associated with melioidosis, and the mechanisms causing this variation are unknown; genomic differences among strains offer one explanation. We compared the genome sequences of two strains of\n            <jats:italic>B. pseudomallei<\/jats:italic>\n            : the original reference strain K96243 from Thailand and strain MSHR305 from Australia. We identified a variable homologous region between the two strains. This region was previously identified in comparisons of the genome of\n            <jats:italic>B. pseudomallei<\/jats:italic>\n            strain K96243 with the genome of strain E264 from the closely related\n            <jats:italic>B. thailandensis<\/jats:italic>\n            . In that comparison, K96243 was shown to possess a horizontally acquired\n            <jats:italic>Yersinia<\/jats:italic>\n            -like fimbrial (YLF) gene cluster. Here, we show that the homologous genomic region in\n            <jats:italic>B. pseudomallei<\/jats:italic>\n            strain 305 is similar to that previously identified in\n            <jats:italic>B. thailandensis<\/jats:italic>\n            strain E264. We have named this region in\n            <jats:italic>B. pseudomallei<\/jats:italic>\n            strain 305 the\n            <jats:italic>B. thailandensis<\/jats:italic>\n            -like flagellum and chemotaxis (BTFC) gene cluster. We screened for these different genomic components across additional genome sequences and 571\n            <jats:italic>B. pseudomallei<\/jats:italic>\n            DNA extracts obtained from regions of endemicity. These alternate genomic states define two distinct groups within\n            <jats:italic>B. pseudomallei<\/jats:italic>\n            : all strains contained either the BTFC gene cluster (group BTFC) or the YLF gene cluster (group YLF). These two groups have distinct geographic distributions: group BTFC is dominant in Australia, and group YLF is dominant in Thailand and elsewhere. In addition, clinical isolates are more likely to belong to group YLF, whereas environmental isolates are more likely to belong to group BTFC. These groups should be further characterized in an animal model.\n          <\/jats:p>","DOI":"10.1128\/jb.01264-07","type":"journal-article","created":{"date-parts":[[2007,10,13]],"date-time":"2007-10-13T00:44:20Z","timestamp":1192236260000},"page":"9044-9049","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":81,"title":["A Horizontal Gene Transfer Event Defines Two Distinct Groups within\n            <i>Burkholderia pseudomallei<\/i>\n            That Have Dissimilar Geographic Distributions"],"prefix":"10.1128","volume":"189","author":[{"given":"Apichai","family":"Tuanyok","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona 86011-5640"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond K.","family":"Auerbach","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona 86011-5640"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Brettin","sequence":"additional","affiliation":[{"name":"Los Alamos National Laboratory, Los Alamos, New Mexico 87545"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Bruce","sequence":"additional","affiliation":[{"name":"Los Alamos National Laboratory, Los Alamos, New Mexico 87545"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Christine","family":"Munk","sequence":"additional","affiliation":[{"name":"Los Alamos National Laboratory, Los Alamos, New Mexico 87545"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Chris","family":"Detter","sequence":"additional","affiliation":[{"name":"Los Alamos National Laboratory, Los Alamos, New Mexico 87545"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talima","family":"Pearson","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona 86011-5640"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidie","family":"Hornstra","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona 86011-5640"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasana W.","family":"Sermswan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanaporn","family":"Wuthiekanun","sequence":"additional","affiliation":[{"name":"Wellcome Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon J.","family":"Peacock","sequence":"additional","affiliation":[{"name":"Wellcome Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart J.","family":"Currie","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Keim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona 86011-5640"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona 86011-5640"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-48-1-317"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti553"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.2.383-416.2005"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.12.5477-5483.2004"},{"key":"e_1_3_2_6_2","first-page":"272","volume":"27","year":"2003","unstructured":"Cheng, A. 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