{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:29:25Z","timestamp":1789615765203,"version":"build-2803163510"},"reference-count":8,"publisher":"American Society for Microbiology","issue":"19","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Brucella melitensis<\/jats:named-content>\n            is an intracellular pathogen that induces chronic infection in humans. Here, we report the genome sequences of 16M and its two derivatives, 16M1w and 16M13w, which were allowed to adapt\n            <jats:italic>in vivo<\/jats:italic>\n            for 1 and 13 weeks, respectively. Our findings contribute to the investigation of adaptive mutations and mechanisms of chronic infection by\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. melitensis<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/jb.01293-12","type":"journal-article","created":{"date-parts":[[2012,9,10]],"date-time":"2012-09-10T19:40:00Z","timestamp":1347306000000},"page":"5489-5489","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Genome Sequences of Brucella melitensis 16M and Its Two Derivatives 16M1w and 16M13w, Which Evolved\n            <i>In Vivo<\/i>"],"prefix":"10.1128","volume":"194","author":[{"given":"Yuehua","family":"Ke","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Control, Beijing Institute of Disease Control and Prevention, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xitong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Beijing Institute of Disease Control and Prevention, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Beijing Institute of Disease Control and Prevention, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoxia","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Beijing Institute of Disease Control and Prevention, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Beijing Institute of Disease Control and Prevention, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Beijing Institute of Disease Control and Prevention, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuyu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Beijing Institute of Disease Control and Prevention, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Beijing Institute of Disease Control and Prevention, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-75"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/j.1365-294X.2010.04835.x","article-title":"Next-generation sequencing as a tool to study microbial evolution","volume":"20","author":"Brockhurst MA","year":"2011","unstructured":"BrockhurstMA ColegraveN RozenDE. 2011. Next-generation sequencing as a tool to study microbial evolution. Mol. Ecol. 20:972\u2013980.","journal-title":"Mol. Ecol."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/msb.2011.42","article-title":"Microbial laboratory evolution in the era of genome-scale science","volume":"7","author":"Conrad TM","year":"2011","unstructured":"ConradTM LewisNE PalssonBO. 2011. Microbial laboratory evolution in the era of genome-scale science. Mol. Syst. Biol. 7:509.","journal-title":"Mol. Syst. Biol."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.811"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm160"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.5.955"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/ng.815","article-title":"Estimating the mutation rate of Mycobacterium tuberculosis during infection","volume":"43","author":"Sherman DR","year":"2011","unstructured":"ShermanDR GagneuxS. 2011. Estimating the mutation rate of Mycobacterium tuberculosis during infection. Nat. Genet. 43:400\u2013401.","journal-title":"Nat. Genet."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2012.00334.x"}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.01293-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.01293-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T17:28:38Z","timestamp":1627579718000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JB.01293-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":8,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1128\/JB.01293-12"],"URL":"https:\/\/doi.org\/10.1128\/jb.01293-12","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"2012-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-07-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-09-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}