{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:46:16Z","timestamp":1789681576627,"version":"4.0.1"},"reference-count":56,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Chorismate mutase (CM) catalyzes the rearrangement of chorismate to prephenate in the biosynthetic pathway that forms phenylalanine and tyrosine in bacteria, fungi, plants, and apicomplexan parasites. Since this enzyme is absent from mammals, it represents a promising target for the development of new antimycobacterial drugs, which are needed to combat\n            <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n            , the causative agent of tuberculosis. Until recently, two putative open reading frames (ORFs), Rv0948c and Rv1885c, showing low sequence similarity to CMs have been described as \u201cconserved hypothetical proteins\u201d in the\n            <jats:italic>M. tuberculosis<\/jats:italic>\n            genome. However, we and others demonstrated that these ORFs are in fact monofunctional CMs of the AroQ structural class and that they are differentially localized in the mycobacterial cell. Since homologues to the\n            <jats:italic>M. tuberculosis<\/jats:italic>\n            enzymes are also present in\n            <jats:italic>Mycobacterium smegmatis<\/jats:italic>\n            , we cloned the coding sequences corresponding to ORFs MSMEG5513 and MSMEG2114 from the latter. The CM activities of both ORFs was determined, as well as their translational start sites. In addition, we analyzed the promoter activities of three\n            <jats:italic>M. tuberculosis<\/jats:italic>\n            loci related to phenylalanine and tyrosine biosynthesis under a variety of conditions using\n            <jats:italic>M. smegmatis<\/jats:italic>\n            as a surrogate host. Our results indicate that the\n            <jats:italic>aroQ<\/jats:italic>\n            (Rv0948c), *\n            <jats:italic>aroQ<\/jats:italic>\n            (Rv1885c), and\n            <jats:italic>fbpB<\/jats:italic>\n            (Rv1886c) genes from\n            <jats:italic>M. tuberculosis<\/jats:italic>\n            are constitutively expressed or subjected to minor regulation by aromatic amino acids levels, especially tryptophan.\n          <\/jats:p>","DOI":"10.1128\/jb.01332-07","type":"journal-article","created":{"date-parts":[[2007,10,26]],"date-time":"2007-10-26T23:13:00Z","timestamp":1193440380000},"page":"122-134","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["The Two Chorismate Mutases from both\n            <i>Mycobacterium tuberculosis<\/i>\n            and\n            <i>Mycobacterium smegmatis<\/i>\n            : Biochemical Analysis and Limited Regulation of Promoter Activity by Aromatic Amino Acids"],"prefix":"10.1128","volume":"190","author":[{"given":"Cristopher Z.","family":"Schneider","sequence":"first","affiliation":[{"name":"Centro de Pesquisas em Biologia Molecular e Funcional, Instituto de Pesquisas Biome\u0301dicas, Pontifi\u0301cia Universidade Cato\u0301lica do Rio Grande do Sul, Av. Ipiranga 6681, Porto Alegre, RS 90619-900, Brazil"},{"name":"Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary's School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom"},{"name":"Centro de Biotecnologia, Programa de Po\u0301s-Graduac\u0327a\u0303o em Biologia Celular e Molecular, Universidade Federal do Rio Grande do Sul, Av. Bento Gonc\u0327alves 9500, Porto Alegre, RS 91501-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Parish","sequence":"additional","affiliation":[{"name":"Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary's School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz A.","family":"Basso","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas em Biologia Molecular e Funcional, Instituto de Pesquisas Biome\u0301dicas, Pontifi\u0301cia Universidade Cato\u0301lica do Rio Grande do Sul, Av. Ipiranga 6681, Porto Alegre, RS 90619-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dio\u0301genes S.","family":"Santos","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas em Biologia Molecular e Funcional, Instituto de Pesquisas Biome\u0301dicas, Pontifi\u0301cia Universidade Cato\u0301lica do Rio Grande do Sul, Av. Ipiranga 6681, Porto Alegre, RS 90619-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/BF01568535","volume":"16","year":"1988","unstructured":"Ahmad, S., and R. A. Jensen. 1988. Phylogenetic distribution of components of the overflow pathway to l-phenylalanine within the enteric lineage of bacteria. Curr. Microbiol. 16 : 295-302.","journal-title":"Curr. 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