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Although OspC is an essential virulence factor needed by the spirochete to establish infection in the mammal, it represents a potent target for the host acquired immune response, and constitutive expression of OspC results in spirochete clearance. In this study, we demonstrate that a factor encoded on a linear plasmid of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. burgdorferi<\/jats:named-content>\n            , lp17, can negatively regulate\n            <jats:italic>ospC<\/jats:italic>\n            transcription from the endogenous gene on the circular plasmid cp26 and from an\n            <jats:italic>ospC<\/jats:italic>\n            promoter-\n            <jats:italic>lacZ<\/jats:italic>\n            fusion on a shuttle vector. Furthermore, we have identified\n            <jats:italic>bbd18<\/jats:italic>\n            as the gene on lp17 that is responsible for this effect. These data identify a novel component of\n            <jats:italic>ospC<\/jats:italic>\n            regulation and provide the basis for determining the molecular mechanisms of\n            <jats:italic>ospC<\/jats:italic>\n            repression\n            <jats:italic>in vivo<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/jb.01496-10","type":"journal-article","created":{"date-parts":[[2011,7,23]],"date-time":"2011-07-23T04:47:30Z","timestamp":1311396450000},"page":"5365-5373","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Regulation of the Virulence Determinant OspC by\n            <i>bbd18<\/i>\n            on Linear Plasmid lp17 of Borrelia burgdorferi"],"prefix":"10.1128","volume":"193","author":[{"given":"Amit","family":"Sarkar","sequence":"first","affiliation":[{"name":"Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIAID, NIH, 903 S. 4th St., Hamilton, Montana 59840"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth M.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIAID, NIH, 903 S. 4th St., Hamilton, Montana 59840"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Dulebohn","sequence":"additional","affiliation":[{"name":"Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIAID, NIH, 903 S. 4th St., Hamilton, Montana 59840"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Rosa","sequence":"additional","affiliation":[{"name":"Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIAID, NIH, 903 S. 4th St., Hamilton, Montana 59840"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"521","article-title":"Isolation and cultivation of Lyme disease spirochetes","volume":"57","author":"Barbour A. 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