{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:53:26Z","timestamp":1779353606265,"version":"3.51.4"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Phenotypic evaluation of isogenic mutants derived from<jats:italic>Brucella abortus<\/jats:italic>2308 indicates that the AlcR homolog DhbR (2,3-<jats:italic>d<\/jats:italic>i<jats:italic>h<\/jats:italic>ydroxy<jats:italic>b<\/jats:italic>enzoic acid [2,3-DHBA] biosynthesis<jats:italic>r<\/jats:italic>egulator) modulates the expression of the genes involved in 2,3-DHBA production, employing 2,3-DHBA or brucebactin as a coinducer.<\/jats:p>","DOI":"10.1128\/jb.01551-07","type":"journal-article","created":{"date-parts":[[2007,12,22]],"date-time":"2007-12-22T01:44:05Z","timestamp":1198287845000},"page":"1838-1842","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["The AraC-Like Transcriptional Regulator DhbR Is Required for Maximum Expression of the 2,3-Dihydroxybenzoic Acid Biosynthesis Genes in<i>Brucella abortus<\/i>2308 in Response to Iron Deprivation"],"prefix":"10.1128","volume":"190","author":[{"given":"Eric S.","family":"Anderson","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, North Carolina 27834"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James T.","family":"Paulley","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, North Carolina 27834"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"II","given":"R. Martin","family":"Roop","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, North Carolina 27834"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Techniques for the brucellosis laboratory. 1988"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-6445(03)00055-X"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0021-9258(18)74509-2","volume":"118","year":"1937","unstructured":"Arnow, L. E. 1937. Colorimetric determination of the components of 3,4-dihydroxyphenyalanine-tyrosine mixtures. J. Biol. Chem. 118 : 531-537.","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.4.862-870.1998"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.5.2615-2618.1999"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.4.1794-1803.2003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.2.483-489.2001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3201\/eid0302.970219","volume":"3","year":"1997","unstructured":"Corbel, M. J. 1997. Brucellosis: an overview. Emerg. Infect. Dis. 3 : 213-221.","journal-title":"Emerg. Infect. Dis."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/mmbr.61.3.319-336.1997"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1093\/jn\/128.12.2295","volume":"128","year":"1998","unstructured":"Eisenstein, R. S., and K. P. Blemings. 1998. Iron regulatory proteins, iron responsive elements and iron homeostasis. J. Nutr. 128 : 2295-2298.","journal-title":"J. Nutr."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.10.4135-4139.1994"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.20.6223-6229.1999"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"678","DOI":"10.3181\/00379727-89-21914","volume":"89","year":"1955","unstructured":"Evenson, M. A., and P. Gerhardt. 1955. Nutrition of Brucellae: utilization of iron, magnesium, and manganese for growth. Proc. Soc. Exp. Biol. Med. 89 : 678-680.","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1046\/j.1365-2958.1996.00118.x","volume":"22","year":"1996","unstructured":"Fetherston, J. D., S. W. Bearden, and R. D. Perry. 1996. YbtA, an AraC-type regulator of the Yersinia pestis pesticin\/yersiniabactin receptor. Mol. Microbiol. 22 : 315-325.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.5.2873-2880.2005"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1099\/00221287-148-2-353","volume":"148","year":"2002","unstructured":"Gonz\u00e1lez Carrer\u00f3, M. I., F. J. Sangari, J. Ag\u00fcero, and J. M. Garc\u00eda-Lobo. 2002. Brucella abortus strain 2308 produces brucebactin, a highly efficient catecholic siderophore. Microbiology 148 : 353-360.","journal-title":"Microbiology"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"21669","DOI":"10.1074\/jbc.273.34.21669","volume":"273","year":"1998","unstructured":"Hamza, I., S. Chauhan, R. Hassett, and M. R. O'Brian. 1998. The bacterial Irr protein is required for coordination of heme biosynthesis with iron availability. J. Biol. Chem. 273 : 21669-21674.","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.18.5882-5889.1993"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.9.2586-2592.1996"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(95)00584-1"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.11.4496-4503.1992"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.8.2576-2585.2001"},{"key":"e_1_3_2_24_2","first-page":"495","volume":"58","year":"2004","unstructured":"Michel, L., N. Gonz\u00e1lez, S. Jagdeep, T. Nguyen-Ngoc, and C. Reimmann. 2004. PchR-box recognition by the AraC-type regulator PchR of Pseudomonas aeruginosa requires the siderophore pyochelin as an effector. Mol. Microbiol. 58 : 495-509.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_25_2","first-page":"352","year":"1972","unstructured":"Miller, J. H. 1972. Experiments in molecular genetics, p. 352-355. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.","journal-title":"Experiments in molecular genetics"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/mpat.2002.0500","volume":"32","year":"2002","unstructured":"Parent, M. A., B. H. Bellaire, E. A. Murphy, R. M. Roop II, P. H. Elzer, and C. L. Baldwin. 2002. Brucella abortus siderophore 2,3-dihydroxybenzoic acid (DHBA) facilitates intracellular survival of the bacteria. Microb. Pathog. 32 : 239-248.","journal-title":"Microb. Pathog."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00460-07"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.3.538-546.1998"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1023\/A:1009252919854","volume":"12","year":"1999","unstructured":"Pierre, J. L., and M. Fontecave. 1999. Iron and activated oxygen species in biology: the basic chemistry. Biometals 12 : 195-199.","journal-title":"Biometals"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.4.871-880.1998"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1046\/j.1365-2958.2000.01726.x","volume":"35","year":"2000","unstructured":"Robertson, G. T., M. E. Kovach, C. A. Allen, T. A. Ficht, and R. M. Roop II. 2000. The Brucella abortus Lon functions as a generalized stress response protease and is required for wild-type virulence in BALB\/c mice. Mol. Microbiol. 35 : 577-588.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"e163","DOI":"10.1371\/journal.pcbi.0020163","volume":"2","year":"2006","unstructured":"Rodionov, D. A., M. S. Gelfland, J. D. Todd, A. R. J. Curson, and A. W. B. Johnston. 2006. Computational reconstruction of iron- and manganese-responsive transcriptional networks in \u03b1-proteobacteria. PLoS Comput. Biol. 2 : e163.","journal-title":"PLoS Comput. Biol."},{"key":"e_1_3_2_33_2","first-page":"243","year":"2004","unstructured":"Roop, R. M., II, B. H. Bellaire, E. Anderson, and J. T. Paulley. 2004. Iron metabolism in Brucella, p. 243-262. In I. L\u00f3pez-Go\u00f1i and I. Moriy\u00f3n (ed.), Brucella: molecular and cellular biology. Horizon Bioscience, Norfolk, United Kingdom.","journal-title":"Brucella: molecular and cellular biology."},{"key":"e_1_3_2_34_2","first-page":"46","volume":"160","year":"1987","unstructured":"Schwyn, B., and J. B. Neilands. 1987. Universal chemical assay for the detection and determination of siderophores. Anal. Biochem. 160 : 46-56.","journal-title":"Anal. Biochem."},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1099\/00221287-148-12-4059","volume":"148","year":"2002","unstructured":"Todd, J. D., M. Wexler, G. Sawers, K. H. Yeoman, P. S. Poole, and A. W. B. Johnston. 2002. RirA, an iron-responsive regulator in the symbiotic bacterium Rhizobium leguminosarum. Microbiology 148 : 4059-4071.","journal-title":"Microbiology"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.66.1.82-91.1953"}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.01551-07","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.01551-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T19:14:26Z","timestamp":1708456466000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JB.01551-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1128\/JB.01551-07"],"URL":"https:\/\/doi.org\/10.1128\/jb.01551-07","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]},"assertion":[{"value":"2007-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}