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Comparison of putative mycobacterial transport genes revealed a single annotated open reading frame (ORF) for a multidrug and toxic compound extrusion (MATE) family efflux pump in all sequenced mycobacteria except\n            <jats:italic>Mycobacterium leprae<\/jats:italic>\n            . Since MATE efflux pumps function as multidrug efflux pumps by conferring resistance to structurally diverse antibiotics and DNA-damaging chemicals, we studied this gene (MSMEG_2631) in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">M. smegmatis<\/jats:named-content>\n            mc\n            <jats:sup>2<\/jats:sup>\n            155 and determined that it encodes a MATE efflux system that contributes to intrinsic resistance of\n            <jats:italic>Mycobacterium<\/jats:italic>\n            . We propose that the MSMEG_2631 gene be named\n            <jats:italic>mmp<\/jats:italic>\n            , for\n            <jats:underline>m<\/jats:underline>\n            ycobacterial\n            <jats:underline>M<\/jats:underline>\n            ATE\n            <jats:underline>p<\/jats:underline>\n            rotein. Biolog Phenotype MicroArray data indicated that\n            <jats:italic>mmp<\/jats:italic>\n            deletion increased susceptibility for phleomycin, bleomycin, capreomycin, amikacin, kanamycin, cetylpyridinium chloride, and several sulfa drugs. MSMEG_2619 (\n            <jats:italic>efpA<\/jats:italic>\n            ) and MSMEG_3563 mask the effect of\n            <jats:italic>mmp<\/jats:italic>\n            deletion due to overlapping efflux capabilities. We present evidence that\n            <jats:italic>mmp<\/jats:italic>\n            is a part of an MSMEG_2626-2628-2629-2630-2631 operon regulated by a strong constitutive promoter, initiated from a single transcription start site. All together, our results show that\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">M. smegmatis<\/jats:named-content>\n            constitutively encodes an Na\n            <jats:sup>+<\/jats:sup>\n            -dependent MATE multidrug efflux pump from\n            <jats:italic>mmp<\/jats:italic>\n            in an operon with putative genes encoding proteins for apparently unrelated functions.\n          <\/jats:p>","DOI":"10.1128\/jb.01724-12","type":"journal-article","created":{"date-parts":[[2013,1,5]],"date-time":"2013-01-05T06:56:15Z","timestamp":1357368975000},"page":"1610-1621","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["Characterization of the MSMEG_2631 Gene (\n            <i>mmp<\/i>\n            ) Encoding a Multidrug and Toxic Compound Extrusion (MATE) Family Protein in Mycobacterium smegmatis and Exploration of Its Polyspecific Nature Using Biolog Phenotype MicroArray"],"prefix":"10.1128","volume":"195","author":[{"given":"Mukti Nath","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Texas A&amp;M Health Science Center Irma Lerma Rangel College of Pharmacy, Kingsville, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lacy","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Texas A&amp;M Health Science Center Irma Lerma Rangel College of Pharmacy, Kingsville, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"WHO (World Health Organization). 2011. 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