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We hypothesized that 60A, another EAEC strain, might posses virulence or fitness genes that 042 does not have. Through subtractive hybridization we identified 60A-specific sequences, including loci present in other<jats:italic>E. coli<\/jats:italic>and phage DNA. One locus thus identified was<jats:italic>impB<\/jats:italic>, a LexA repressed error-prone DNA repair gene that has been identified in plasmids from other enteric organisms and which we detected in 21 of 34 EAEC strains. An isogenic 60A<jats:italic>impB<\/jats:italic>mutant showed decreased survival and mutagenesis after exposure to UV, as well as bile salt exposure, compared to the wild-type strain, and these phenotypes could be complemented in trans. The EAEC strain 60A<jats:italic>imp<\/jats:italic>operon differs structurally from previously described homologs. A cryptic gene,<jats:italic>impC<\/jats:italic>, present in other<jats:italic>imp<\/jats:italic>operons, is absent from 60A. In addition, transcription of<jats:italic>impAB<\/jats:italic>in strain 60A occurs from a promoter that is dissimilar to the previously described<jats:italic>impC<\/jats:italic>promoter but is still triggered by UV-mediated damage. In strain 60A the<jats:italic>impAB<\/jats:italic>and the aggregative adherence fimbriae I (AAF\/I)-encoding genes are on the same large plasmid, and the 60A version of the operon is predominantly seen in AAF\/I-positive EAEC. Supplementary<jats:italic>imp<\/jats:italic>SOS-inducible error-prone repair systems are common among EAEC even though they are absent in prototypical strain 042.<\/jats:p>","DOI":"10.1128\/jb.01764-06","type":"journal-article","created":{"date-parts":[[2007,3,10]],"date-time":"2007-03-10T01:52:05Z","timestamp":1173491525000},"page":"3793-3803","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Error-Prone DNA Repair System in Enteroaggregative<i>Escherichia coli<\/i>Identified by Subtractive Hybridization"],"prefix":"10.1128","volume":"189","author":[{"given":"Lucy M.","family":"Joo","sequence":"first","affiliation":[{"name":"Department of Biology, Haverford College, 370 Lancaster Ave., Haverford, Pennsylvania 19041"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louissa R.","family":"Macfarlane-Smith","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Bradford, West Yorkshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iruka N.","family":"Okeke","sequence":"additional","affiliation":[{"name":"Department of Biology, Haverford College, 370 Lancaster Ave., Haverford, Pennsylvania 19041"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"884","DOI":"10.7326\/0003-4819-136-12-200206180-00009","volume":"136","year":"2002","unstructured":"Adachi, J. 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