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Phylogenetic analysis of the response regulator NtrX showed that this two-component system is extensively distributed across the bacterial domain, and it is present in a variety of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Betaproteobacteria<\/jats:named-content>\n            , including the human pathogen\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Neisseria gonorrhoeae<\/jats:named-content>\n            . Microarray analysis revealed that the expression of several components of the respiratory chain was reduced in an\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">N. gonorrhoeae<\/jats:named-content>\n            <jats:italic>ntrX<\/jats:italic>\n            mutant compared to that in the isogenic wild-type (WT) strain 1291. These included the cytochrome\n            <jats:italic>c<\/jats:italic>\n            oxidase subunit (\n            <jats:italic>ccoP<\/jats:italic>\n            ), nitrite reductase (\n            <jats:italic>aniA<\/jats:italic>\n            ), and nitric oxide reductase (\n            <jats:italic>norB<\/jats:italic>\n            ). Enzyme activity assays showed decreased cytochrome oxidase and nitrite reductase activities in the\n            <jats:italic>ntrX<\/jats:italic>\n            mutant, consistent with microarray data.\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">N. gonorrhoeae<\/jats:named-content>\n            <jats:italic>ntrX<\/jats:italic>\n            mutants had reduced capacity to survive inside primary cervical cells compared to the wild type, and although they retained the ability to form a biofilm, they exhibited reduced survival within the biofilm compared to wild-type cells, as indicated by LIVE\/DEAD staining. Analyses of an\n            <jats:italic>ntrX<\/jats:italic>\n            mutant in a representative alphaproteobacterium,\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Rhodobacter capsulatus<\/jats:named-content>\n            , showed that cytochrome oxidase activity was also reduced compared to that in the wild-type strain SB1003. Taken together, these data provide evidence that the NtrYX two-component system may be a key regulator in the expression of respiratory enzymes and, in particular, cytochrome\n            <jats:italic>c<\/jats:italic>\n            oxidase, across a wide range of proteobacteria, including a variety of bacterial pathogens.\n          <\/jats:p>","DOI":"10.1128\/jb.02062-12","type":"journal-article","created":{"date-parts":[[2013,4,6]],"date-time":"2013-04-06T04:37:25Z","timestamp":1365223045000},"page":"2632-2641","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["Characterization of an\n            <i>ntrX<\/i>\n            Mutant of Neisseria gonorrhoeae Reveals a Response Regulator That Controls Expression of Respiratory Enzymes in Oxidase-Positive Proteobacteria"],"prefix":"10.1128","volume":"195","author":[{"given":"John M.","family":"Atack","sequence":"first","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia"},{"name":"Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogitha N.","family":"Srikhanta","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karrera Y.","family":"Djoko","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica P.","family":"Welch","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norain H. 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