{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T08:03:07Z","timestamp":1772611387115,"version":"3.50.1"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"19","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Amycolatopsis mediterranei<\/jats:named-content>\n            S699 is an actinomycete that produces an important antibiotic, rifamycin B. Semisynthetic derivatives of rifamycin B are used for the treatment of tuberculosis, leprosy, and AIDS-related mycobacterial infections. Here, we report the complete genome sequence (10.2 Mb) of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. mediterranei<\/jats:named-content>\n            S699, with 9,575 predicted coding sequences.\n          <\/jats:p>","DOI":"10.1128\/jb.05819-11","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T19:09:53Z","timestamp":1315940993000},"page":"5562-5563","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Whole Genome Sequence of the Rifamycin B-Producing Strain Amycolatopsis mediterranei S699"],"prefix":"10.1128","volume":"193","author":[{"given":"Mansi","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Zoology, University of Delhi, Delhi 110 007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaspreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Delhi, Delhi 110 007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Delhi, Delhi 110 007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirti","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Delhi, Delhi 110 007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Delhi, Delhi 110 007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailly","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Delhi, Delhi 110 007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aeshna","family":"Nigam","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Delhi, Delhi 110 007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vydianathan","family":"Ravi","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre for Plant Genomics &amp; Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110 021, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saurabh","family":"Raghuvanshi","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre for Plant Genomics &amp; Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110 021, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paramjit","family":"Khurana","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre for Plant Genomics &amp; Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110 021, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akhilesh K.","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre for Plant Genomics &amp; Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110 021, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitendra P.","family":"Khurana","sequence":"additional","affiliation":[{"name":"Interdisciplinary Centre for Plant Genomics &amp; Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110 021, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rup","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Delhi, Delhi 110 007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1021\/bi010080z","article-title":"The loading module of rifamycin synthetase is an adenylation-thiolation didomain with tolerance for substituted benzoates","volume":"40","author":"Admiraal S. J.","year":"2001","unstructured":"AdmiraalS. J. WalshC. T. KhoslaC.. 2001. The loading module of rifamycin synthetase is an adenylation-thiolation didomain with tolerance for substituted benzoates. Biochemistry 40:6116\u20136123.","journal-title":"Biochemistry"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1074-5521(98)90141-7","article-title":"Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699","volume":"5","author":"August P. R.","year":"1998","unstructured":"AugustP. R. . 1998. Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699. Chem. Biol. 5:69\u201379.","journal-title":"Chem. Biol."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/bioinformatics\/bti091","article-title":"BACCardI\u2014a tool for the validation of genomic assemblies, assisting genome finishing and intergenome comparison","volume":"21","author":"Bartels D.","year":"2005","unstructured":"BartelsD. . 2005. BACCardI\u2014a tool for the validation of genomic assemblies, assisting genome finishing and intergenome comparison. Bioinformatics. 21:853\u2013859.","journal-title":"Bioinformatics."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0041-3879(87)90053-5","article-title":"In vitro activity of new rifamycins against rifampicin-resistant M. tuberculosis and MAIS-complex mycobacteria","volume":"68","author":"Dickinson J. M.","year":"1987","unstructured":"DickinsonJ. M. MitchisonD. A.. 1987. In vitro activity of new rifamycins against rifampicin-resistant M. tuberculosis and MAIS-complex mycobacteria. Tubercle 68:177\u2013182.","journal-title":"Tubercle"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.7164\/antibiotics.53.484","article-title":"Thioesterases and the premature termination of polyketide chain elongation in rifamycin B biosynthesis by Amycolatopsis mediterranei S699","volume":"53","author":"Doi-Katayama Y.","year":"2000","unstructured":"Doi-KatayamaY. . 2000. Thioesterases and the premature termination of polyketide chain elongation in rifamycin B biosynthesis by Amycolatopsis mediterranei S699. J. Antibiot. (Tokyo) 53:484\u2013495.","journal-title":"J. Antibiot. (Tokyo)"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/10408419509113532","article-title":"Rifamycins: strain improvement program","volume":"21","author":"Lal R.","year":"1995","unstructured":"LalR. . 1995. Rifamycins: strain improvement program. Crit. Rev. Microbiol. 21:19\u201330.","journal-title":"Crit. Rev. 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Bacteriol."},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF02089930","article-title":"Rifomycin. XI. Taxonomic study of Streptomyces mediterranei nov. sp","volume":"13","author":"Margalith P.","year":"1960","unstructured":"MargalithP. BerettaG.. 1960. Rifomycin. XI. Taxonomic study of Streptomyces mediterranei nov. sp. Mycopathol. Mycol. Appl. 13:321\u2013330.","journal-title":"Mycopathol. Mycol. Appl."},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1574-6968.1998.tb12861.x","article-title":"Cloning and sequence analysis of the putative rifamycin polyketide synthase gene cluster from Amycolatopsis mediterranei","volume":"159","author":"Schupp T.","year":"1998","unstructured":"SchuppT. ToupetC. EngelN. GoffS.. 1998. Cloning and sequence analysis of the putative rifamycin polyketide synthase gene cluster from Amycolatopsis mediterranei. FEMS Microbiol. 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Gene 216:255\u2013265.","journal-title":"Gene"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF00409680","article-title":"A proposal for the transfer of Streptomyces mediterranei Margalith and Beretta 1960 to the genus Nocardia as Nocardia mediterranea (Margalith and Beretta) comb. nov","volume":"67","author":"Thiemann J. E.","year":"1969","unstructured":"ThiemannJ. E. ZuccoG. PelizzaG.. 1969. A proposal for the transfer of Streptomyces mediterranei Margalith and Beretta 1960 to the genus Nocardia as Nocardia mediterranea (Margalith and Beretta) comb. nov. Arch. Mikrobiol. 67:147\u2013155.","journal-title":"Arch. Mikrobiol."},{"key":"e_1_3_2_15_2","first-page":"586","article-title":"In vitro susceptibility of Mycobacterium avium complex and Mycobacterium tuberculosis strains to a spiro-piperidyl rifamycin","volume":"126","author":"Woodley C. L.","year":"1982","unstructured":"WoodleyC. L. KilburnJ. O.. 1982. In vitro susceptibility of Mycobacterium avium complex and Mycobacterium tuberculosis strains to a spiro-piperidyl rifamycin. Am. Rev. Respir. Dis. 126:586\u2013587.","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1099\/mic.0.28138-0","article-title":"Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699","volume":"151","author":"Xu J.","year":"2005","unstructured":"XuJ. WanE. KimC. J. FlossH. G. MahmudT.. 2005. Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699. 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