{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:11:16Z","timestamp":1791277876034,"version":"4.1.0"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"19","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Mycobacterium bovis<\/jats:named-content>\n            bacillus Calmette-Gu\u00e9rin (BCG) is the only vaccine available against tuberculosis, and the strains used worldwide represent a family of daughter strains with distinct genotypic characteristics. Here we report the complete genome sequence of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">M. bovis<\/jats:named-content>\n            BCG Moreau, the strain in continuous use in Brazil for vaccine production since the 1920s.\n          <\/jats:p>","DOI":"10.1128\/jb.05827-11","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T19:09:53Z","timestamp":1315940993000},"page":"5600-5601","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":44,"title":["Genome Sequence of Mycobacterium bovis BCG Moreau, the Brazilian Vaccine Strain against Tuberculosis"],"prefix":"10.1128","volume":"193","author":[{"given":"Leonardo H. F.","family":"Gomes","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00f4mica Funcional e Bioinform\u00e1tica, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Otto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00f4mica Funcional e Bioinform\u00e1tica, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil"},{"name":"Centro de Pesquisas Arlindo de Assis, Funda\u00e7\u00e3o Ataulpho de Paiva, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9rico A.","family":"Vasconcellos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00f4mica Funcional e Bioinform\u00e1tica, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil"},{"name":"Centro de Pesquisas Arlindo de Assis, Funda\u00e7\u00e3o Ataulpho de Paiva, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia M.","family":"Ferr\u00e3o","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00f4mica Funcional e Bioinform\u00e1tica, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata M.","family":"Maia","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Arlindo de Assis, Funda\u00e7\u00e3o Ataulpho de Paiva, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline S.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00f4mica Funcional e Bioinform\u00e1tica, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo A.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00f4mica Funcional e Bioinform\u00e1tica, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz R. R.","family":"Castello-Branco","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Arlindo de Assis, Funda\u00e7\u00e3o Ataulpho de Paiva, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim M.","family":"Degrave","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00f4mica Funcional e Bioinform\u00e1tica, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Mendon\u00e7a-Lima","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00f4mica Funcional e Bioinform\u00e1tica, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5419.1520"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1590\/S0074-02762005000500002","article-title":"BCG Moreau Rio de Janeiro: an oral vaccine against tuberculosis","volume":"100","author":"Ben\u00e9volo-de-Andrade T. C.","year":"2005","unstructured":"Ben\u00e9volo-de-AndradeT. C. Monteiro-MaiaR. CosgroveC. Castello-BrancoL. R.. 2005. BCG Moreau Rio de Janeiro: an oral vaccine against tuberculosis. Review. Mem. Inst. Oswaldo Cruz 100:459\u2013465.","journal-title":"Review. Mem. Inst. Oswaldo Cruz"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1471-2180-11-80","article-title":"Proteomic profile of culture filtrate from the Brazilian vaccine strain Mycobacterium bovis BCG Moreau compared to M. bovis BCG Pasteur","volume":"11","author":"Berr\u00eado-Pinho M.","year":"2011","unstructured":"Berr\u00eado-PinhoM. . 2011. Proteomic profile of culture filtrate from the Brazilian vaccine strain Mycobacterium bovis BCG Moreau compared to M. bovis BCG Pasteur. BMC Microbiol. 11:80.","journal-title":"BMC Microbiol."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700869104"},{"key":"e_1_3_2_6_2","first-page":"1","article-title":"La vaccination preventive de la tuberculose par le BCG (bacille Calmette-Gu\u00e9rin). Rapport pr\u00e9sent\u00e9 \u00e0 la Conf\u00e9rence Internationale du BCG r\u00e9unie \u00e0 Paris du 15 au 18 octobre 1928 et organis\u00e9 par la Section d'Hygi\u00e8ne de la Soci\u00e9t\u00e9 des Nations","volume":"42","author":"Calmette A.","year":"1928","unstructured":"CalmetteA. 1928. La vaccination preventive de la tuberculose par le BCG (bacille Calmette-Gu\u00e9rin). Rapport pr\u00e9sent\u00e9 \u00e0 la Conf\u00e9rence Internationale du BCG r\u00e9unie \u00e0 Paris du 15 au 18 octobre 1928 et organis\u00e9 par la Section d'Hygi\u00e8ne de la Soci\u00e9t\u00e9 des Nations. Ann. Inst. Pasteur 42(Suppl.):1\u201360.","journal-title":"Ann. Inst. Pasteur"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/31159"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1130426100"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.8.3.195"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1574-695X.2009.00559.x","article-title":"Comparable studies of immunostimulating activities in vitro among Mycobacterium bovis bacillus Calmette-Guerin (BCG) substrains","volume":"56","author":"Hayashi D.","year":"2009","unstructured":"HayashiD. . 2009. Comparable studies of immunostimulating activities in vitro among Mycobacterium bovis bacillus Calmette-Guerin (BCG) substrains. FEMS Immunol. Med. Microbiol. 56:116\u2013128.","journal-title":"FEMS Immunol. Med. 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World Health Organization Geneva Switzerland. http:\/\/whqlibdoc.who.int\/hq\/2010\/WHO_IVB_2010_eng_p32-R242.pdf."}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.05827-11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.05827-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T17:21:01Z","timestamp":1627579261000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JB.05827-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":19,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1128\/JB.05827-11"],"URL":"https:\/\/doi.org\/10.1128\/jb.05827-11","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"2011-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-07-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}