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Biofilm development is positively regulated by\n            <jats:italic>hmsT<\/jats:italic>\n            , encoding a diguanylate cyclase that synthesizes the bacterial second messenger cyclic-di-GMP. Biofilm development is negatively regulated by the Rcs phosphorelay signal transduction system. In this study, we show that Rcs-negative regulation is accomplished by repressing transcription of\n            <jats:italic>hmsT.<\/jats:italic>\n          <\/jats:p>","DOI":"10.1128\/jb.06243-11","type":"journal-article","created":{"date-parts":[[2012,2,11]],"date-time":"2012-02-11T05:30:54Z","timestamp":1328938254000},"page":"2020-2026","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":50,"title":["The Yersinia pestis Rcs Phosphorelay Inhibits Biofilm Formation by Repressing Transcription of the Diguanylate Cyclase Gene\n            <i>hmsT<\/i>"],"prefix":"10.1128","volume":"194","author":[{"given":"Yi-Cheng","family":"Sun","sequence":"first","affiliation":[{"name":"MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"},{"name":"Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA"},{"name":"Department of Cell &amp; Tissue Biology, Program in Microbial Pathogenesis and Host Response, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Peng","family":"Guo","sequence":"additional","affiliation":[{"name":"MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Joseph","family":"Hinnebusch","sequence":"additional","affiliation":[{"name":"Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Creg","family":"Darby","sequence":"additional","affiliation":[{"name":"Department of Cell &amp; Tissue Biology, Program in Microbial Pathogenesis and Host Response, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"17837","DOI":"10.1073\/pnas.0408026101","article-title":"Microevolution and history of the plague bacillus, Yersinia pestis.","volume":"101","author":"Achtman M","year":"2004","unstructured":"AchtmanM . 2004. Microevolution and history of the plague bacillus, Yersinia pestis. Proc. Natl. Acad. Sci. 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