{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T05:35:06Z","timestamp":1648964106788},"reference-count":7,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1972,8,1]],"date-time":"1972-08-01T00:00:00Z","timestamp":81475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[1972,8]]},"abstract":"<jats:p>\n            Premature cessation of rapid, exponential growth and a low final cell yield were observed with a thermophilic bacillus in a glucose-mineral salts-vitamin medium. Restricted growth was not due to nutrient or oxygen limitation, to depressed\n            <jats:italic>p<\/jats:italic>\n            H, or to the physical effects of \u201ccrowding.\u201d Glucose conversion to cellular material was efficient at a low glucose charge (0.1%), but decreased with increasing concentrations of glucose. The likelihood that an autoinhibitor(s) was being produced was considered. Further studies revealed that an autoinhibitor appeared in the culture supernatant fluid at the end of the exponential phase. The factor was soluble in 75% ethanol which precipitated a large amount of extracellular slime. The crude inhibitor in the alcohol filtrate was dialyzable and withstood 3 hr of incubation at\n            <jats:italic>p<\/jats:italic>\n            H 2 or 12, and 30 min of boiling.\n          <\/jats:p>","DOI":"10.1128\/jb.111.2.459-464.1972","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T14:37:40Z","timestamp":1578062260000},"page":"459-464","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Production of an Autoinhibitor by a Thermophilic Bacillus"],"prefix":"10.1128","volume":"111","author":[{"given":"T. W.","family":"Chou","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Greasham","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Tannenbaum","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. L.","family":"Demain","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_1","first-page":"1244","article-title":"Studies on the utilization of hydrocarbons by yeasts. 4. On the dialysis culture of Mycotorula japonica and \"growth-inhibitory factor","volume":"33","author":"Aida T.","year":"1969","unstructured":"Aida , T. , and K. Yamaguchi . 1969 . Studies on the utilization of hydrocarbons by yeasts. 4. On the dialysis culture of Mycotorula japonica and \"growth-inhibitory factor \" in the dialyzable material. Agr. Biol. Chem. 33 : 1244 - 1250 .","journal-title":"the dialyzable material. Agr. Biol. Chem."},{"key":"p_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF00409313","article-title":"Growth inhibitor produced by the green algae (Volvocaceae)","volume":"76","author":"Harris D.","year":"1971","unstructured":"Harris , D. 0. 1971 . Growth inhibitor produced by the green algae (Volvocaceae) . Arch. Mikrobiol. 76 : 47 - 50 .","journal-title":"Arch. Mikrobiol."},{"key":"p_3","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1126\/science.163.3863.192","article-title":"Phenethyl alcohol and triptophol: autoantibiotics produced by the fungus, Candida albicans","volume":"163","author":"Lingappa B. T.","year":"1969","unstructured":"Lingappa , B. T. , M. Prasad , Y. Lingappa , D. F. Hunt , and K. Biemann . 1969 . Phenethyl alcohol and triptophol: autoantibiotics produced by the fungus, Candida albicans . Science 163 : 192 - 194 .","journal-title":"Science"},{"key":"p_4","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1365-2672.1970.tb02211.x","article-title":"The dynamics of decane and glucose utilization by a Pseudomonas sp. in batch and chemostat cultures under controlled dissolved oxygen tensions","volume":"33","author":"Maclennon D. G.","year":"1970","unstructured":"Maclennon , D. G. , and S. J. Pirt . 1970 . The dynamics of decane and glucose utilization by a Pseudomonas sp. in batch and chemostat cultures under controlled dissolved oxygen tensions . J. Appl. Bacteriol. 33 : 390 - 396 .","journal-title":"J. Appl. Bacteriol."},{"key":"p_5","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.157.3794.1322","article-title":"Growth of a thermophilic bacterium on hydrocarbons: a new source of single-cell protein","volume":"157","author":"Mateles R. I.","year":"1967","unstructured":"Mateles , R. I. , J. Baruah , and S. R. Tannenbaum . 1967 . Growth of a thermophilic bacterium on hydrocarbons: a new source of single-cell protein . Science 157 : 1322 - 1323 .","journal-title":"Science"},{"key":"p_6","first-page":"F17","article-title":"Isolation and study of mutants selected from Candida tropicalis cultivated on hydrocarbons. Antonie van Leeuwenhoek J","volume":"35","author":"Pasero J.","year":"1969","unstructured":"Pasero , J. , Z. Duvnjak , and E. Azoulay . 1969 . Isolation and study of mutants selected from Candida tropicalis cultivated on hydrocarbons. Antonie van Leeuwenhoek J . Microbiol. Serol. 35 (supplement ): F17 - F18 .","journal-title":"Microbiol. Serol."},{"key":"p_7","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1128\/jb.106.3.882-889.1971","article-title":"Mucopolysaccharide which regulates growth in Neurospora","volume":"106","author":"Reissig J. L.","year":"1971","unstructured":"Reissig , J. L. , and J. E. Glasgow . 1971 . Mucopolysaccharide which regulates growth in Neurospora . J. 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