{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T17:55:48Z","timestamp":1762710948771},"reference-count":24,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1973,7,1]],"date-time":"1973-07-01T00:00:00Z","timestamp":110332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[1973,7]]},"abstract":"<jats:p>\n            The\n            <jats:italic>Escherichia coli<\/jats:italic>\n            mutant\n            <jats:italic>hfl-1<\/jats:italic>\n            is lysogenized at very high frequency by bacteriophage lambda. The normal requirement for the \u03bb\n            <jats:italic>c<\/jats:italic>\n            III gene product in the establishment of repression is not observed in\n            <jats:italic>hfl-1<\/jats:italic>\n            strains. These phenotypic characteristics are specified by a single locus at 82.5 min on the\n            <jats:italic>E. coli<\/jats:italic>\n            map in extremely close proximity to the\n            <jats:italic>purA<\/jats:italic>\n            gene, cotransduction frequencies ranging from 97 to 100% depending on the particular\n            <jats:italic>purA<\/jats:italic>\n            marker used. The lactose operon is shown to function normally in this strain, and there are also no demonstrable differences in ribonucleic acid polymerase activity or cyclic-adenosine monophosphate levels. Alterations in the cell envelope are indicated by a slight rifamycin resistance, which is reversible by pretreating the cells with ethylenediaminetetraacetic acid, and by a resistance to penicillin and a sensitivity to high concentrations of sodium dodecyl sulfate. It is not known whether this change in cell surface is the primary lesion, or a pleiotropic effect of some more basic metabolic shift.\n          <\/jats:p>","DOI":"10.1128\/jb.115.1.299-306.1973","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T14:53:02Z","timestamp":1578063182000},"page":"299-306","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Genetic and Biochemical Investigation of the\n            <i>Escherichia coli<\/i>\n            Mutant\n            <i>hfl-1<\/i>\n            Which is Lysogenized at High Frequency by Bacteriophage Lambda"],"prefix":"10.1128","volume":"115","author":[{"given":"Marlene","family":"Belfort","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92664"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel L.","family":"Wulff","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92664"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1101\/SQB.1963.028.01.051","article-title":"Production of messenger RNA and regulation of protein synthesis","volume":"28","author":"Attardi G. S.","year":"1963","unstructured":"Attardi , G. S. , J. Naono , J. Rouviere , F. Jacob , and F. Gros . 1963 . Production of messenger RNA and regulation of protein synthesis . Cold Spring Harbor Symp. Quant. Biol. 28 : 363 - 372 .","journal-title":"Cold Spring Harbor Symp. Quant. Biol."},{"key":"p_2","unstructured":"Belfort M. and D. L. Wulff. 1971. A mutant of Escherichia coli that is Iysogenized with high frequency p. 739-742. In A. Hershey (ed.) The bacteriophage lambda. Cold Spring Harbor Laboratory Cold Spring Harbor New York."},{"key":"p_3","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.1016\/S0021-9258(18)63520-3","article-title":"A new method for the large scale purification of Escherichia coli deoxyribonucleic aciddependent ribonucleic acid polymerase","volume":"224","author":"Burgess R. R.","year":"1969","unstructured":"Burgess , R. R. 1969 . A new method for the large scale purification of Escherichia coli deoxyribonucleic aciddependent ribonucleic acid polymerase . J. Biol. Chem. 224 : 6160 - 6167 .","journal-title":"J. Biol. Chem."},{"key":"p_4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.ge.06.120172.001105","article-title":"Developmental pathways for the temperate phage: Iysis vs","volume":"6","author":"Echols H. A.","year":"1972","unstructured":"Echols , H. A. 1972 . Developmental pathways for the temperate phage: Iysis vs Iysogeny. Annu. Rev. Genet. 6 : 157 - 190 .","journal-title":"Iysogeny. Annu. Rev. Genet."},{"key":"p_5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1017\/S0016672300011769","article-title":"Resistance of Escherichia coli to penicillins. II. An improved mapping of the ampA gene","volume":"12","author":"Eriksson-Grennberg K. G.","year":"1968","unstructured":"Eriksson-Grennberg , K. G. 1968 . Resistance of Escherichia coli to penicillins. II. An improved mapping of the ampA gene . Genet. Res. 12 : 147 - 156 .","journal-title":"Genet. Res."},{"key":"p_6","first-page":"698","article-title":"Genetic mapping of mutations affecting phosphoglucose isomerase and fructose diphosphatase in Escherichia coli","volume":"57","author":"Fraenkel D. G.","year":"1967","unstructured":"Fraenkel , D. G. 1967 . Genetic mapping of mutations affecting phosphoglucose isomerase and fructose diphosphatase in Escherichia coli . Proc. Nat. Acad. Sci. U.S.A. 57 : 698 - 705 .","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"p_7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1073\/pnas.67.1.305","article-title":"A protein binding assay for adenosine 3': 5'-cyclic monophosphate","volume":"67","author":"Gilman A. E.","year":"1970","unstructured":"Gilman , A. E. 1970 . A protein binding assay for adenosine 3': 5'-cyclic monophosphate . Proc. Nat. Acad. Sci. U.S.A. 67 : 305 - 312 .","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"p_8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0022-2836(69)90408-2","article-title":"Directed transposition of the arabinose operon: a technique for the isolation of specialized transducing bacteriophages for any Escherichia coli gene","volume":"44","author":"Gottesman S.","year":"1969","unstructured":"Gottesman , S. , and J. Beckwith . 1969 . Directed transposition of the arabinose operon: a technique for the isolation of specialized transducing bacteriophages for any Escherichia coli gene . J. Mol. Biol. 44 : 117 - 127 .","journal-title":"J. Mol. Biol."},{"key":"p_9","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0022-2836(68)90423-3","article-title":"Integration negative mutants of lambda","volume":"31","author":"Gottesman M. E.","year":"1968","unstructured":"Gottesman , M. E. , and M. Yarmolinsky . 1968 . Integration negative mutants of lambda . J. Mol. Biol. 31 : 487 - 505 .","journal-title":"J. Mol. Biol."},{"key":"p_10","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1073\/pnas.69.2.366","article-title":"Establishment of repression in lambdoid phage in catabolite activator protein and adenylate cyclase mutants of Escherichia coli","volume":"69","author":"Grodzicker T.","year":"1972","unstructured":"Grodzicker , T. , R. R. Arditti , and H. Eisen . 1972 . Establishment of repression in lambdoid phage in catabolite activator protein and adenylate cyclase mutants of Escherichia coli . Proc. Nat. Acad. Sci. U.S.A. 69 : 366 - 370 .","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"p_11","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1073\/pnas.68.9.2258","article-title":"Adenosine 3': 5'-cyclic monophosphate concentration in the bacterial host regulates the viral decision between Iysogeny and Iysis","volume":"68","author":"Hong J.","year":"1971","unstructured":"Hong , J. , G. R. Smith , and B. N. Ames . 1971 . Adenosine 3': 5'-cyclic monophosphate concentration in the bacterial host regulates the viral decision between Iysogeny and Iysis . Proc. Nat. Acad. Sci. U.S.A. 68 : 2258 - 2262 .","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"p_12","doi-asserted-by":"crossref","unstructured":"Jacob R. and E. L. Wollman. 1959. Lysogeny p. 319-351. In F. N. Burnet and W. M. Stanley (ed.) The viruses vol. 2. Academic Press Inc. New York.","DOI":"10.1016\/B978-0-12-395675-0.50014-2"},{"key":"p_13","first-page":"418","article-title":"Control of the rate of enzyme synthesis in Aerobacter aerogenes","volume":"81","author":"Kennel D.","year":"1964","unstructured":"Kennel , D. , and B. Magasanik . 1964 . Control of the rate of enzyme synthesis in Aerobacter aerogenes . Biochem. Biophys. Acta 81 : 418 - 434 .","journal-title":"Biochem. Biophys. Acta"},{"key":"p_14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0006-291X(65)90874-0","article-title":"Actinomycin sensitivity in Escherichia coli produced by EDTA","volume":"18","author":"Leive L.","year":"1965","unstructured":"Leive , L. 1965 . Actinomycin sensitivity in Escherichia coli produced by EDTA . Biochem. Biophys. Res. Comm. 18 : 13 - 17 .","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"p_15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry 0.","year":"1951","unstructured":"Lowry , 0. H. , N. J. Rosebrough , A. L. Farr , and R. J. Randall . 1951 . Protein measurement with the folin phenol reagent . J. Biol. Chem. 193 : 263 - 275 .","journal-title":"J. Biol. Chem."},{"key":"p_16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1128\/JB.74.4.461-476.1957","article-title":"Hybridization between Escherichia coli and Shigella","volume":"74","author":"Luria S. E.","year":"1957","unstructured":"Luria , S. E. , and J. W. Burrous . 1957 . Hybridization between Escherichia coli and Shigella . J. Bacteriol. 74 : 461 - 476 .","journal-title":"J. Bacteriol."},{"key":"p_17","unstructured":"Magasanik B. 1970. Glucose effects: inducer exclusion and repression p. 189-219. In J. R. Beckwith and D. Zipser (ed.) The lactose operon. Cold Spring Harbor Laboratory Cold Spring Harbor New York."},{"key":"p_18","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0006-3002(51)90072-8","article-title":"Sur la biosynthese de la ,B-galactosidase (lactase) chez Escherichia coli. La specificite de l'induction","volume":"7","author":"Monod J.","year":"1951","unstructured":"Monod , J. , G. Cohen-Bazire , and M. Cohn . 1951 . Sur la biosynthese de la ,B-galactosidase (lactase) chez Escherichia coli. La specificite de l'induction . Biochem. Biophys. Acta 7 : 585 - 599 .","journal-title":"Biochem. Biophys. Acta"},{"key":"p_19","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1128\/JB.94.4.1093-1111.1967","article-title":"Interaction of colicins with bacterial cells. III. Colicin-tolerant mutations in Escherichia coli","volume":"94","author":"Nomura M.","year":"1967","unstructured":"Nomura , M. , and C. Witten . 1967 . Interaction of colicins with bacterial cells. III. Colicin-tolerant mutations in Escherichia coli . J. Bacteriol. 94 : 1093 - 1111 .","journal-title":"J. Bacteriol."},{"key":"p_20","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1126\/science.169.3943.339","article-title":"Cyclic adenosine monophosphate in bacteria","volume":"169","author":"Pastan I.","year":"1970","unstructured":"Pastan , I. , and R. Perlman . 1970 . Cyclic adenosine monophosphate in bacteria . Science 169 : 339 - 344 .","journal-title":"Science"},{"key":"p_21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1128\/BR.34.2.155-175.1970","article-title":"Current linkage map of Escherichia coli","volume":"34","author":"Taylor A. L.","year":"1970","unstructured":"Taylor , A. L. 1970 . Current linkage map of Escherichia coli . Bacteriol. Rev. 34 : 155 - 175 .","journal-title":"Bacteriol. Rev."},{"key":"p_22","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1128\/BR.31.4.332-353.1967","article-title":"The genetic map of Escherichia coli","volume":"31","author":"Taylor A. L.","year":"1964","unstructured":"Taylor , A. L. , and M. S. Thoman . 1964 . The genetic map of Escherichia coli . Bacteriol. Rev. 31 : 332 - 353 .","journal-title":"Bacteriol. Rev."},{"key":"p_23","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1128\/JB.98.2.837-839.1969","article-title":"Mapping of a structural gene for valyl-transfer ribonucleic acid synthetase in Escherichia coli by transduction","volume":"98","author":"Tingle A.","year":"1969","unstructured":"Tingle , A. , and F. C. Neidhardt . 1969 . Mapping of a structural gene for valyl-transfer ribonucleic acid synthetase in Escherichia coli by transduction . J. Bacteriol. 98 : 837 - 839 .","journal-title":"J. Bacteriol."},{"key":"p_24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1128\/jb.110.1.18-25.1972","article-title":"Biochemical and genetic studies on ubiquinone biosynthesis in Escherichia coli K-12: 4- hydroxybenzoate octaprenyltransferase","volume":"110","author":"Young I. G.","year":"1972","unstructured":"Young , I. G. , R. A. Leppik , J. A. Hamilton , and F. Gibson . 1972 . Biochemical and genetic studies on ubiquinone biosynthesis in Escherichia coli K-12: 4- hydroxybenzoate octaprenyltransferase . J. Bacteriol. 110 : 18 - 25 .","journal-title":"J. Bacteriol."}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jb.115.1.299-306.1973","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jb.115.1.299-306.1973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T17:07:24Z","timestamp":1627578444000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jb.115.1.299-306.1973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,7]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1973,7]]}},"alternative-id":["10.1128\/jb.115.1.299-306.1973"],"URL":"https:\/\/doi.org\/10.1128\/jb.115.1.299-306.1973","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,7]]},"assertion":[{"value":"2021-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}