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Uptake did not depend upon Mg2+, Ca2+, Zn2+, Na+, or Fe2+ ions. Reversible p-hydroxymercuribenzoate inhibition of uptake indicated the involvement of an active sulfhydryl group. L-Glutamate uptake was mediated by a glutamate-inducible, nonspecific transport system, which was extremely stable and was not subject to substrate inhibition by L-proline. On the other hand, L-proline transport was mediated by at least two systems. The L-glutamate-inducible nonspecific system can account for uptake of proline by the mycelium grown in glutamate. In addition, a proline-specific, constitutive transport system was found to be present in the mycelium grown in organic and inorganic nitrogen sources other than L-glutamate. Shift experiments revealed that proline transport is not as stable as glutamate transport when the glutamate-inducible nonspecific system is utilized.<\/jats:p>","DOI":"10.1128\/jb.134.2.546-554.1978","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T16:23:24Z","timestamp":1578068604000},"page":"546-554","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Glutamate-induced uptake of proline by Streptomyces antibioticus"],"prefix":"10.1128","volume":"134","author":[{"suffix":"Jr","given":"W S","family":"May","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J V","family":"Formica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/0003-9861(67)90187-7","article-title":"Specificity and regulation of methionine transport in filamentous fungi","volume":"122","author":"Benko P. 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