{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T20:50:15Z","timestamp":1674852615339},"reference-count":27,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1981,9,1]],"date-time":"1981-09-01T00:00:00Z","timestamp":368150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[1981,9]]},"abstract":"<jats:p>Cells of Saccharomyces carlsbergensis 4228 grown aerobically with added thiamine (1 microgram . ml-1) in a vitamin B6-free medium contained no detectable heme precursors, such as delta-aminolevulinate, coproporphyrin III, or protoporphyrin IX. The deficiency in heme precursors in the thiamine-grown cells was accompanied by previously reported phenomena, i.e., growth depression, vitamin B6 deficiency, and respiratory deficiency due to a marked decrease in the activities of heme-containing enzymes and cytochrome level (I. Nakamura et al., FEBS Lett. 62: 354-358, 1976). It has been reported that all of the effects of thiamine are abolished by adding pyridoxine to the medium. delta-Aminolevulinate was found to have quite similar effects to those of pyridoxine, except that growth was partially improved by delta-aminolevulinate, whereas it was fully restored by pyridoxine. Incubation of the thiamine-grown cells with delta-aminolevulinate resulted in the appearance of the heme precursors and the heme-containing enzymes. Consistent with the lowered amount of vitamin B6, the thiamine-grown cells had a lowered activity of delta-aminolevulinate synthase, a pyridoxal phosphate-dependent enzyme. Not only the holoenzyme activity but also the apoenzyme activity was very low in these cells. These results indicate that the thiamine-induced vitamin B6 deficiency brings about the decrease in delta-aminolevulinate synthase activity, which leads to heme deficiency and therefore to respiratory deficiency.<\/jats:p>","DOI":"10.1128\/jb.147.3.954-961.1981","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T17:24:24Z","timestamp":1578072264000},"page":"954-961","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Mechanism of thiamine-induced respiratory deficiency in Saccharomyces carlsbergensis"],"prefix":"10.1128","volume":"147","author":[{"given":"I","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kamihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1016\/S0021-9258(19)62350-1","article-title":"Crystallization and characterization of a new proteaae in mitochondria of bone marrow celLs","volume":"263","author":"Aoki Y.","year":"1978","unstructured":"Aoki , Y. 1978 . Crystallization and characterization of a new proteaae in mitochondria of bone marrow celLs . J. Biol. Chem. 263 : 2026 - 2032 .","journal-title":"J. Biol. Chem."},{"key":"p_2","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1172\/JCI109573","article-title":"8-Aminolevulinic acid synthetase in erythroblasts of patients with pyridoxine-responsive anemia. Hypercatabolism caused by the increased suaceptibility to the controlling protease","volume":"64","author":"Aoki Y.","year":"1979","unstructured":"Aoki , Y. , S. Muranaka , K. Nakabayashi , and Y. Ueda . 1979 . 8-Aminolevulinic acid synthetase in erythroblasts of patients with pyridoxine-responsive anemia. Hypercatabolism caused by the increased suaceptibility to the controlling protease . J. Clin. Invest. 64 : 1196 - 1203 .","journal-title":"J. Clin. Invest."},{"key":"p_3","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1172\/JCI107680","article-title":"Measurements of 8-aminolevulinic acid synthetase activity in human erythroblaats","volume":"53","author":"Aoki Y.","year":"1974","unstructured":"Aoki , Y. , G. Urata , 0. Wada , and F. Takak }u. 1974 . Measurements of 8-aminolevulinic acid synthetase activity in human erythroblaats . J. Clin. Invest. 53 : 1326 - 1334 .","journal-title":"J. Clin. Invest."},{"key":"p_4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0076-6879(57)04060-4","article-title":"Techniques for the asay of the respiratory enzymes","volume":"4","author":"Chance B.","year":"1957","unstructured":"Chance , B. 1957 . Techniques for the asay of the respiratory enzymes . Methods Enzymol. 4 : 273 - 329 .","journal-title":"Methods Enzymol."},{"key":"p_5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0003-9861(56)90248-X","article-title":"Some factors affecting the inhibitory action ofthiamine on the growth of Saccharomyces carlsbergensis","volume":"64","author":"Chiao J. S.","year":"1956","unstructured":"Chiao , J. S. , and W. H. Peterson . 1956 . Some factors affecting the inhibitory action ofthiamine on the growth of Saccharomyces carlsbergensis . Arch. Biochem. Biophys. 64 : 115 - 128 .","journal-title":"Arch. Biochem. Biophys."},{"key":"p_6","unstructured":"Falk J. E. 1964. Porphyrin and metalloporphyrin p. 165-173. Elsevier\/North-Holland Publishing Co. Amsterdam."},{"key":"p_7","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/S0021-9258(18)95986-7","article-title":"Succinyl coenzyme Asynthetase from Escherichia coli. I. Purification and properties","volume":"242","author":"Gibson J.","year":"1967","unstructured":"Gibson , J. , C. D. Upper , and I. C. Gusalus . 1967 . Succinyl coenzyme Asynthetase from Escherichia coli. I. Purification and properties . J. Biol. Chem. 242 : 2474 - 2477 .","journal-title":"J. Biol. Chem."},{"key":"p_8","first-page":"84","article-title":"Hemes, chlorophylls, and related compounds: biosynthesis and metabolic regulation","volume":"46","author":"Granick S.","year":"1978","unstructured":"Granick , S. , and S. I. Beale . 1978 . Hemes, chlorophylls, and related compounds: biosynthesis and metabolic regulation . Advances Enzymol. Relat. Areas Mol. Biol. 46 : 84 - 176 .","journal-title":"Advances Enzymol. Relat. Areas Mol. Biol."},{"key":"p_9","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0021-9258(18)81340-0","article-title":"Increase in activity of 8-aminolevulinic acid synthetase in liver mitochondria induced by feeding of 3,5-dicarbethxoy-1,4-dihydrocollidine","volume":"238","author":"Gramick S.","year":"1963","unstructured":"Gramick , S. , and G. Urata 1963 . Increase in activity of 8-aminolevulinic acid synthetase in liver mitochondria induced by feeding of 3,5-dicarbethxoy-1,4-dihydrocollidine . J. Biol. Chem. 238 : 821 - 827 .","journal-title":"J. Biol. Chem."},{"key":"p_10","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/0076-6879(71)18354-1","article-title":"Microbiological determination of the vitamin B6 group","volume":"18","author":"Haskell B. E.","year":"1970","unstructured":"Haskell , B. E. , and E. E. Snell . 1970 . Microbiological determination of the vitamin B6 group . Methods Enzymol. 18 : 512 - 517 .","journal-title":"Methods Enzymol."},{"key":"p_11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0003-9861(69)90107-6","article-title":"Mechanism of allylisopropyl-acetamide-induced increase of 8- aminolevulinate synthetase in liver mitochondria. IV. Accumulation of the enzyme in the soluble fraction of rat liver","volume":"131","author":"Hayashi N.","year":"1969","unstructured":"Hayashi , N. , B. Yoda , and G. Kikuchi . 1969 . Mechanism of allylisopropyl-acetamide-induced increase of 8- aminolevulinate synthetase in liver mitochondria. IV. Accumulation of the enzyme in the soluble fraction of rat liver . Arch. Biochem. Biophys. 131 : 83 - 91 .","journal-title":"Arch. Biochem. Biophys."},{"key":"p_12","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0083-6729(08)60774-8","article-title":"Pyridoxineresponsive anemia in man","volume":"26","author":"Horrigan D. L","year":"1968","unstructured":"Horrigan , D. L , and J. W. Harris . 1968 . Pyridoxineresponsive anemia in man . Vitam. Horm. N. Y. 26 : 549 - 568 .","journal-title":"Vitam. Horm. N. Y."},{"key":"p_13","first-page":"328","article-title":"The relation between thiamine and vitamin B6 on Saccharomyces carlsbergen 8is 4228. V. The effect of thiamine on vitamin B6 contents of the yeast during its growth","volume":"32","author":"Kawasaki C.","year":"1965","unstructured":"Kawasaki , C. , and C. Yamada . 1965 . The relation between thiamine and vitamin B6 on Saccharomyces carlsbergen 8is 4228. V. The effect of thiamine on vitamin B6 contents of the yeast during its growth . Bitamin (Kyoto) 32 : 328 - 331 . (In Japanese.)","journal-title":"Bitamin (Kyoto)"},{"key":"p_14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0003-9861(77)90145-X","article-title":"Changes in the activities of the protoheme-synthesizing system during the growth of yeast under different conditions","volume":"179","author":"Labbe-Bois R.","year":"1977","unstructured":"Labbe-Bois , R. , and C. Volland . 1977 . Changes in the activities of the protoheme-synthesizing system during the growth of yeast under different conditions . Arch. Biochem. Biophys. 179 : 565 - 577 .","journal-title":"Arch. Biochem. Biophys."},{"key":"p_15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry 0.","year":"1951","unstructured":"Lowry , 0. IL , N. J. Rosebrough , A. L. Farr , and R. J. Randall . 1951 . Protein measurement with the Folin phenol reagent . J. Biol. Chem. 193 : 265 - 275 .","journal-title":"J. Biol. Chem."},{"key":"p_16","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/0006-291X(74)90249-6","article-title":"The derepression of 8-aminolevulinate synthetase in yeast","volume":"61","author":"Mahler EL R","year":"1974","unstructured":"Mahler , EL R . , and C. C. in. 1974 . The derepression of 8-aminolevulinate synthetase in yeast . Biochem. Biophys. Res. Commun. 61 : 963 - 970 .","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"p_17","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0021-9258(18)65809-0","article-title":"The occurrence and determination of 6-aminolevulinic acid and porphobilinogen in urine","volume":"219","author":"Mauzerall D.","year":"1956","unstructured":"Mauzerall , D. , and S. Granick . 1956 . The occurrence and determination of 6-aminolevulinic acid and porphobilinogen in urine . J. Biol. Chem. 219 : 435 - 446 .","journal-title":"J. Biol. Chem."},{"key":"p_18","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1128\/JB.98.2.573-578.1969","article-title":"Alteration in the amino acid content of yeast during growth under various nutritional conditions","volume":"98","author":"Moat A. G.","year":"1969","unstructured":"Moat , A. G. , F. Ahmad , J. K Alexander , and I. J. Barnes . 1969 . Alteration in the amino acid content of yeast during growth under various nutritional conditions . J. Bacteriol. 98 : 573 - 578 .","journal-title":"J. Bacteriol."},{"key":"p_19","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0076-6879(63)06257-1","article-title":"Chromatographic determination of amino acids by the use of automatic recording equipment","volume":"6","author":"Moore S.","year":"1963","unstructured":"Moore , S. , and W. H. Stein . 1963 . Chromatographic determination of amino acids by the use of automatic recording equipment . Methods Enzymol. 6 : 819 - 831 .","journal-title":"Methods Enzymol."},{"key":"p_20","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0006-291X(74)90276-9","article-title":"Effects of thiamine and pyridoxine on the content and composition of sterol in Saccharomyces carlsbergensis 4228","volume":"60","author":"Nagai J.","year":"1974","unstructured":"Nagai , J. , H. Katsuki , Y. Nishikawa , I. Nakamura , T. Kamihara , and S. Fukui . 1974 . Effects of thiamine and pyridoxine on the content and composition of sterol in Saccharomyces carlsbergensis 4228 . Biochem. Biophys. Res. Commun. 60 : 555 - 560 .","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"p_21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF00414354","article-title":"Effects of thiamine and pyridoxine on respiratory activity in Saccharomyces carlsbergensis strain 4228","volume":"127","author":"Nakamura I.","year":"1980","unstructured":"Nakamura , I. , N. Isobe , T. Kamihara , and S. Fukui . 1980 . Effects of thiamine and pyridoxine on respiratory activity in Saccharomyces carlsbergensis strain 4228 . Arch. Microbiol. 127 : 47 - 51 .","journal-title":"Arch. Microbiol."},{"key":"p_22","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0006-291X(74)80046-X","article-title":"Respiratory deficiency in Saccharomyces carlsbergensis 4228 caused by thiamine and its prevention by pyridoxine","volume":"59","author":"Naamura I.","year":"1974","unstructured":"Naamura , I. , Y. Nishikawa , T. Kamihara , and S. Fukul . 1974 . Respiratory deficiency in Saccharomyces carlsbergensis 4228 caused by thiamine and its prevention by pyridoxine . Biochem. Biophys. Res. Commun. 59 : 771 - 776 .","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"p_23","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/0014-5793(76)80093-2","article-title":"Thiamine-induced reversible deficiency in respiratory activity of Saccharomyces carlsbergensis: respiratory adaptation caused by pyridoxine","volume":"62","author":"Nakamura I.","year":"1976","unstructured":"Nakamura , I. , Y. Nishikawa , T. Kamihara , and S. Fukui . 1976 . Thiamine-induced reversible deficiency in respiratory activity of Saccharomyces carlsbergensis: respiratory adaptation caused by pyridoxine . FEBS Lett. 62 : 354 - 358 .","journal-title":"FEBS Lett."},{"key":"p_24","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/0005-2760(78)90185-6","article-title":"Thiamine-induced alteration in sterol composition of Saccharomyces carlsbergensis 4228","volume":"531","author":"Nishikawa Y.","year":"1978","unstructured":"Nishikawa , Y. , T. Kamihara , and S. Fukui . 1978 . Thiamine-induced alteration in sterol composition of Saccharomyces carlsbergensis 4228 . Biochian. Biophys. Acta 531 : 86 - 95 .","journal-title":"Biochian. Biophys. Acta"},{"key":"p_25","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0006-291X(74)80047-1","article-title":"Effects of thiamine and pyridoxine on the composition of fatty acids in Saccharomyces carisbergensis 4228","volume":"59","author":"Nishikawa Y.","year":"1974","unstructured":"Nishikawa , Y. , I. Nakamura , T. Kamihara , and S. Fukui . 1974 . Effects of thiamine and pyridoxine on the composition of fatty acids in Saccharomyces carisbergensis 4228 . Biochem. Biophys. Res. Commun. 59 : 777 - 780 .","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"p_26","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0005-2760(77)90098-4","article-title":"Effects of thiamine and pyridoxine on the lipid composition of Saccharomyces carlsbergensis 4228","volume":"486","author":"Nishikawa Y.","year":"1977","unstructured":"Nishikawa , Y. , L. Nakamura , T. , Kamihara , and S. Fukul . 1977 . Effects of thiamine and pyridoxine on the lipid composition of Saccharomyces carlsbergensis 4228 . Biochim. Biophys. Acta 486 : 483 - 489 .","journal-title":"Biochim. Biophys. Acta"},{"key":"p_27","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/0003-9861(51)90133-6","article-title":"The nature of the requirement of Saccharomyces carisbergensis for vitamin B6","volume":"33","author":"Rabinowitz J. C.","year":"1951","unstructured":"Rabinowitz , J. C. , and E. E. Sneil . 1951 . The nature of the requirement of Saccharomyces carisbergensis for vitamin B6 . Arch. Biochem. Biophys. 33 : 472 - 481 .","journal-title":"Arch. Biochem. Biophys."}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jb.147.3.954-961.1981","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jb.147.3.954-961.1981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T17:38:27Z","timestamp":1627580307000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jb.147.3.954-961.1981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,9]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,9]]}},"alternative-id":["10.1128\/jb.147.3.954-961.1981"],"URL":"https:\/\/doi.org\/10.1128\/jb.147.3.954-961.1981","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,9]]},"assertion":[{"value":"2021-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}