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Strains carrying the mutation were transformed back to tetracycline resistance with the high efficiency of a point marker by donor deoxyribonucleic acids from its ancestral strain and from nine other clinical isolates of pneumococcus and by deoxyribonucleic acids from group D Streptococcus faecalis and group B Streptococcus agalactiae strains that also carry conjugative tet elements in their chromosomes. It was not transformed to resistance by tet plasmid deoxyribonucleic acids from either gram-negative or gram-positive species, except for one that carried transposon Tn916, the conjugative tet element present in the chromosomes of some S. faecalis strains. The results showed that the tet determinants in conjugative elements of several streptococcal species share a high degree of deoxyribonucleic acid sequence homology and suggested that they differ from other tet genes.<\/jats:p>","DOI":"10.1128\/jb.148.1.232-240.1981","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T16:41:14Z","timestamp":1578069674000},"page":"232-240","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Homology among tet determinants in conjugative elements of streptococci"],"prefix":"10.1128","volume":"148","author":[{"given":"M D","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Hazum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W R","family":"Guild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1128\/jb.143.1.313-320.1980","article-title":"Conjugative transfer of multiple antibiotic resistance markers in Streptococcus pneumoniae","volume":"143","author":"Buu-Hoi A.","year":"1980","unstructured":"Buu-Hoi , A. , and T. 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