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A comparison by DNA-DNA hybridization of Tn3701 with omega(cat-tet) and Tn3951, carried by Streptococcus pneumoniae BM6001 and by Streptococcus agalactiae B109, respectively, revealed that the two latter structures are also Tn3701-like composite elements. The DNAs of 27 other antibiotic-resistant group A, B, C, and G streptococci and of S. pneumoniae BM4200 showed sequence homologies to Tn3701 (14 strains, including BM4200), to the regions of Tn3701 outside of Tn3703 (5 strains), and to Tn916 alone (8 strains). The DNAs of five strains did not detectably hybridize with any probe. The tetM gene was identified in most chromosomal genetic elements coding for tetracycline-minocycline resistance. Since Tn3701-like elements are widely disseminated among antibiotic-resistant streptococci (47% of the 34 strains studied), we propose that Tn3701 be considered the prototype of chromosomal composite elements.<\/jats:p>","DOI":"10.1128\/jb.172.2.727-734.1990","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T17:11:47Z","timestamp":1479143507000},"page":"727-734","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":60,"title":["Presence of chromosomal elements resembling the composite structure Tn3701 in streptococci"],"prefix":"10.1128","volume":"172","author":[{"given":"C","family":"Le Bougu\u00e9nec","sequence":"first","affiliation":[{"name":"Laboratoire des Staphylocoques et des Streptocoques, Institut Pasteur, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"de Cesp\u00e9d\u00e8s","sequence":"additional","affiliation":[{"name":"Laboratoire des Staphylocoques et des Streptocoques, Institut Pasteur, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Horaud","sequence":"additional","affiliation":[{"name":"Laboratoire des Staphylocoques et des Streptocoques, Institut Pasteur, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_17","unstructured":"Ausubel F. 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