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Resistance to INH in clinical isolates has been correlated with mutations in the\n                    <jats:italic>inhA<\/jats:italic>\n                    ,\n                    <jats:italic>katG<\/jats:italic>\n                    , and\n                    <jats:italic>ahpC<\/jats:italic>\n                    genes. In this report, we describe a new mechanism for INH resistance in\n                    <jats:italic>Mycobacterium smegmatis<\/jats:italic>\n                    . Mutations that reduce NADH dehydrogenase activity (Ndh; type II) cause multiple phenotypes, including (i) coresistance to INH and a related drug, ethionamide; (ii) thermosensitive lethality; and (iii) auxotrophy. These phenotypes are corrected by expression of one of two enzymes: NADH dehydrogenase and the NADH-dependent malate dehydrogenase of the\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    complex. The genetic data presented here indicate that defects in NADH oxidation cause all of the mutant traits and that an increase in the NADH\/NAD\n                    <jats:sup>+<\/jats:sup>\n                    ratio confers INH resistance.\n                  <\/jats:p>","DOI":"10.1128\/jb.180.9.2459-2467.1998","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T11:33:27Z","timestamp":1577792007000},"page":"2459-2467","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":144,"title":["NADH Dehydrogenase Defects Confer Isoniazid Resistance and Conditional Lethality in\n                    <i>Mycobacterium smegmatis<\/i>"],"prefix":"10.1128","volume":"180","author":[{"given":"Lynn","family":"Miesel","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology and Immunology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torin R.","family":"Weisbrod","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology and Immunology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovita A.","family":"Marcinkeviciene","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Biochemistry,2 Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York 10461, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bittman","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Department of Chemistry and Biochemistry, Queens College of the City University of New York, Flushing, New York 113673"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"William R.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology and Immunology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/clinids\/21.1.9","article-title":"Treatment of tuberculosis and tuberculosis infection in adults and children","volume":"21","author":"Ad Hoc Committee of the Scientific Assembly on Microbiology, Tuberculosis, and Pulmonary Infections","year":"1995","unstructured":"Ad Hoc Committee of the Scientific Assembly on Microbiology, Tuberculosis, and Pulmonary Infections Treatment of tuberculosis and tuberculosis infection in adults and children.Clin. 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