{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:32:55Z","timestamp":1791268375268,"version":"4.1.0"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Protein mannosyltransferases (Pmt proteins) initiate O glycosylation of secreted proteins in fungi. We have characterized\n            <jats:italic>PMT6<\/jats:italic>\n            , which encodes the second Pmt protein of the fungal pathogen\n            <jats:italic>Candida albicans<\/jats:italic>\n            . The residues of Pmt6p are 21 and 42% identical to those of\n            <jats:italic>C. albicans<\/jats:italic>\n            Pmt1p and\n            <jats:italic>S. cerevisiae<\/jats:italic>\n            Pmt6p, respectively. Mutants lacking one or two\n            <jats:italic>PMT6<\/jats:italic>\n            alleles grow normally and contain normal Pmt enzymatic activities in cell extracts but show phenotypes including a partial block of hyphal formation (dimorphism) and a supersensitivity to hygromycin B. The morphogenetic defect can be suppressed by overproduction of known components of signaling pathways, including Cek1p, Cph1p, Tpk2p, and Efg1p, suggesting a specific Pmt6p target protein upstream of these components. Mutants lacking both\n            <jats:italic>PMT1<\/jats:italic>\n            and\n            <jats:italic>PMT6<\/jats:italic>\n            are viable and show\n            <jats:italic>pmt1<\/jats:italic>\n            mutant phenotypes and an additional sensitivity to the iron chelator ethylenediamine-di(\n            <jats:italic>o<\/jats:italic>\n            -hydroxyphenylacetic acid). The lack of Pmt6p significantly reduces adherence to endothelial cells and overall virulence in a mouse model of systemic infection. The results suggest that Pmt6p regulates a more narrow subclass of proteins in\n            <jats:italic>C. albicans<\/jats:italic>\n            than Pmt1p, including secreted proteins responsible for morphogenesis and antifungal sensitivities.\n          <\/jats:p>","DOI":"10.1128\/jb.182.11.3063-3071.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:00:58Z","timestamp":1027764058000},"page":"3063-3071","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":94,"title":["Morphogenesis, Adhesive Properties, and Antifungal Resistance Depend on the Pmt6 Protein Mannosyltransferase in the Fungal Pathogen\n            <i>Candida albicans<\/i>"],"prefix":"10.1128","volume":"182","author":[{"given":"Claudia","family":"Timpel","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Institut fu\u0308r Mikrobiologie, Biologisch-Medizinisches Forschungszentrum,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Zink","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Diabetes-Forschungsinstitut, Heinrich-Heine-Universita\u0308t,2 D-40225 Du\u0308sseldorf,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Strahl-Bolsinger","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Lehrstuhl fu\u0308r Zellbiologie und Pflanzenphysiologie, Universita\u0308t Regensburg, Regensburg,3 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Schro\u0308ppel","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Institut fu\u0308r Klinische Mikrobiologie, Immunologie und Hygiene, Universita\u0308t Erlangen, Erlangen,4 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Ernst","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Institut fu\u0308r Mikrobiologie, Biologisch-Medizinisches Forschungszentrum,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0092-8674(00)80081-1","article-title":"Meiotic transvection in fungi","volume":"86","author":"Aramayo R.","year":"1996","unstructured":"Aramayo R. 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