{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:15:35Z","timestamp":1791188135601,"version":"4.1.0"},"reference-count":63,"publisher":"American Society for Microbiology","issue":"24","license":[{"start":{"date-parts":[[2000,12,15]],"date-time":"2000-12-15T00:00:00Z","timestamp":976838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2000,12,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Virulence factors of\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    include hydrogen cyanide (HCN). This secondary metabolite is maximally produced at low oxygen tension and high cell densities during the transition from exponential to stationary growth phase. The\n                    <jats:italic>hcnABC<\/jats:italic>\n                    genes encoding HCN synthase were identified on a genomic fragment complementing an HCN-deficient mutant of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    PAO1. The\n                    <jats:italic>hcnA<\/jats:italic>\n                    promoter was found to be controlled by the FNR-like anaerobic regulator ANR and by the quorum-sensing regulators LasR and RhlR. Primer extension analysis revealed two transcription starts, T1 and T2, separated by 29 bp. Their function was confirmed by transcriptional\n                    <jats:italic>lacZ<\/jats:italic>\n                    fusions. The promoter sequence displayed an FNR\/ANR box at \u221242.5 bp upstream of T2 and a\n                    <jats:italic>lux<\/jats:italic>\n                    box centered around \u221242.5 bp upstream of T1. Expression of the\n                    <jats:italic>hcn<\/jats:italic>\n                    genes was completely abolished when this\n                    <jats:italic>lux<\/jats:italic>\n                    box was deleted or inactivated by two point mutations in conserved nucleotides. The\n                    <jats:italic>lux<\/jats:italic>\n                    box was recognized by both LasR [activated by\n                    <jats:italic>N<\/jats:italic>\n                    -(oxododecanoyl)-homoserine lactone] and RhlR (activated by\n                    <jats:italic>N<\/jats:italic>\n                    -butanoyl-homoserine lactone), as shown by expression experiments performed in quorum-sensing-defective\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    mutants and in the\n                    <jats:italic>N<\/jats:italic>\n                    -acyl-homoserine lactone-negative heterologous host\n                    <jats:italic>P. fluorescens<\/jats:italic>\n                    CHA0. A second, less conserved\n                    <jats:italic>lux<\/jats:italic>\n                    box lying 160 bp upstream of T1 seems to account for enhanced quorum-sensing-dependent expression. Without LasR and RhlR, ANR could not activate the\n                    <jats:italic>hcn<\/jats:italic>\n                    promoter. Together, these data indicate that expression of the\n                    <jats:italic>hcn<\/jats:italic>\n                    promoter from T1 can occur under quorum-sensing control alone. Enhanced expression from T2 appears to rely on a synergistic action between LasR, RhlR, and ANR.\n                  <\/jats:p>","DOI":"10.1128\/jb.182.24.6940-6949.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:00:58Z","timestamp":1027749658000},"page":"6940-6949","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":255,"title":["Transcriptional Control of the Hydrogen Cyanide Biosynthetic Genes\n                    <i>hcnABC<\/i>\n                    by the Anaerobic Regulator ANR and the Quorum-Sensing Regulators LasR and RhlR in\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1128","volume":"182","author":[{"given":"Gabriella","family":"Pessi","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Haas","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.20.6264-6270.1999"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1046\/j.1365-2958.1997.5431906.x","article-title":"Cascade regulation of the two CRP\/FNR-related transcriptional regulators (ANR and DNR) and the denitrification enzymes in Pseudomonas aeruginosa","volume":"25","author":"Arai H.","year":"1997","unstructured":"Arai H. Kodama T. Igarashi Y. Cascade regulation of the two CRP\/FNR-related transcriptional regulators (ANR and DNR) and the denitrification enzymes in Pseudomonas aeruginosa.Mol. Microbiol.25199711411148","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0378-1119(83)90197-X","article-title":"Activity of the hybrid trp-lac (tac) promoter of Escherichia coli in Pseudomonas putida. Construction of broad-host-range, controlled-expression vectors","volume":"26","author":"Bagdasarian M. M.","year":"1983","unstructured":"Bagdasarian M. M. Amann E. Lurz R. R\u00fcckert B. Bagdasarian M. Activity of the hybrid trp-lac (tac) promoter of Escherichia coli in Pseudomonas putida. Construction of broad-host-range, controlled-expression vectors.Gene261983273282","journal-title":"Gene"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1998.1666"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s002039900127","article-title":"Mechanism, regulation, and ecological role of bacterial cyanide biosynthesis","volume":"173","author":"Blumer C.","year":"2000","unstructured":"Blumer C. Haas D. Mechanism, regulation, and ecological role of bacterial cyanide biosynthesis.Arch. Microbiol.1732000170177","journal-title":"Arch. Microbiol."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1099\/00221287-146-10-2417","article-title":"Iron regulation of the hcnABC genes encoding hydrogen cyanide synthase depends on the anaerobic regulator ANR rather than on the global activator GacA in Pseudomonas fluorescens CHA0","volume":"146","author":"Blumer C.","year":"2000","unstructured":"Blumer C. Haas D. Iron regulation of the hcnABC genes encoding hydrogen cyanide synthase depends on the anaerobic regulator ANR rather than on the global activator GacA in Pseudomonas fluorescens CHA0.Microbiology146200024172424","journal-title":"Microbiology"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"14073","DOI":"10.1073\/pnas.96.24.14073","article-title":"Global GacA-steered control of cyanide and exoprotease production in Pseudomonas fluorescens involves specific ribosome binding sites","volume":"96","author":"Blumer C.","year":"1999","unstructured":"Blumer C. Heeb S. Pessi G. Haas D. Global GacA-steered control of cyanide and exoprotease production in Pseudomonas fluorescens involves specific ribosome binding sites.Proc. Natl. Acad. Sci. USA9619991407314078","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.24.7155-7163.1995"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.130.2.826-831.1977"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1139\/m83-209","article-title":"Hydrogen cyanide production by Pseudomonas aeruginosa at reduced oxygen levels","volume":"29","author":"Castric P. A.","year":"1983","unstructured":"Castric P. A. Hydrogen cyanide production by Pseudomonas aeruginosa at reduced oxygen levels.Can. J. Microbiol.29198313441349","journal-title":"Can. J. Microbiol."},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1139\/m75-088","article-title":"Hydrogen cyanide, a secondary metabolite of Pseudomonas aeruginosa","volume":"21","author":"Castric P. A.","year":"1975","unstructured":"Castric P. A. Hydrogen cyanide, a secondary metabolite of Pseudomonas aeruginosa.Can. J. Microbiol.211975613618","journal-title":"Can. J. Microbiol."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF01570186","article-title":"Influence of oxygen on the Pseudomonas aeruginosa hydrogen cyanide synthase","volume":"29","author":"Castric P. A.","year":"1994","unstructured":"Castric P. A. Influence of oxygen on the Pseudomonas aeruginosa hydrogen cyanide synthase.Curr. Microbiol.2919941921","journal-title":"Curr. Microbiol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF02602861","article-title":"The relationship between growth phase and cyanogenesis in Pseudomonas aeruginosa","volume":"2","author":"Castric P. A.","year":"1979","unstructured":"Castric P. A. Ebert R. F. Castric K. F. The relationship between growth phase and cyanogenesis in Pseudomonas aeruginosa.Curr. Microbiol.21979287292","journal-title":"Curr. Microbiol."},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1094\/MPMI.1998.11.11.1119","article-title":"Production of acyl-homoserine lactone quorum-sensing signals by gram-negative plant-associated bacteria","volume":"11","author":"Cha C.","year":"1998","unstructured":"Cha C. Gao P. Chen Y. C. Shaw P. D. Farrand S. K. Production of acyl-homoserine lactone quorum-sensing signals by gram-negative plant-associated bacteria.Mol. Plant-Microbe Interact.11199811191129","journal-title":"Mol. Plant-Microbe Interact."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"9878","DOI":"10.1093\/nar\/16.20.9878","article-title":"A one-tube plasmid DNA mini-preparation suitable for sequencing","volume":"16","author":"Del Sal G.","year":"1988","unstructured":"Del Sal G. Manfioletti G. Schneider C. A one-tube plasmid DNA mini-preparation suitable for sequencing.Nucleic Acids Res.1619889878","journal-title":"Nucleic Acids Res."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","unstructured":"D\u00f6ring\nG. Pseudomonas aeruginosa infection in cystic fibrosis patients\nPseudomonas aeruginosa as an opportunistic pathogen.\nCampa\nM.\nBendinelli\nM.\nFriedman\nH.\n1993\n245\n273\nPlenum Press\nNew York N.Y","DOI":"10.1007\/978-1-4615-3036-7_13"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1046\/j.1365-2958.1999.01261.x","article-title":"Quorum sensing in Vibrio fischeri: elements of the luxl promoter","volume":"31","author":"Egland K. A.","year":"1999","unstructured":"Egland K. A. Greenberg E. P. Quorum sensing in Vibrio fischeri: elements of the luxl promoter.Mol. Microbiol.31199911971204","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_20_2","first-page":"221","article-title":"High efficiency electroporation of Pseudomonas aeruginosa using frozen cell suspensions","volume":"58","author":"Farinha M. A.","year":"1990","unstructured":"Farinha M. A. Kropinski A. M. High efficiency electroporation of Pseudomonas aeruginosa using frozen cell suspensions.FEMS Microbiol. Lett.581990221225","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.4.1648"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1369-5274(98)80009-X","article-title":"Self perception in bacteria: quorum sensing with acylated homoserine lactones","volume":"1","author":"Fuqua C.","year":"1998","unstructured":"Fuqua C. Greenberg E. P. Self perception in bacteria: quorum sensing with acylated homoserine lactones.Curr. Opin. Microbiol.11998183189","journal-title":"Curr. Opin. Microbiol."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.50.1.727"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0378-1119(86)90358-6","article-title":"Molecular cloning of the plasmid RP4 primase region in a multi-host-range tacP expression vector","volume":"48","author":"F\u00fcrste J. P.","year":"1986","unstructured":"F\u00fcrste J. P. Pansegrau W. Frank R. Bl\u00f6cker H. Scholz P. Bagdasarian M. Lanka E. Molecular cloning of the plasmid RP4 primase region in a multi-host-range tacP expression vector.Gene481986119131","journal-title":"Gene"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.9.3000-3009.1991"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/0022-2836(92)91044-P","article-title":"RNA processing modulates the expression of the arcDABC operon in Pseudomonas aeruginosa","volume":"226","author":"Gamper M.","year":"1992","unstructured":"Gamper M. Ganter B. Polito M. R. Haas D. RNA processing modulates the expression of the arcDABC operon in Pseudomonas aeruginosa.J. Mol. Biol.2261992943957","journal-title":"J. Mol. Biol."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.15.4742-4750.1991"},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF00389986","article-title":"Cyanide formation in preparations from Chlorella vulgaris Beijerinck: effect of sonication and amygdalin addition","volume":"131","author":"Gewitz H. S.","year":"1976","unstructured":"Gewitz H. S. Pistorius E. K. Voss H. H. Vennesland B. Cyanide formation in preparations from Chlorella vulgaris Beijerinck: effect of sonication and amygdalin addition.Planta1311976145148","journal-title":"Planta"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/00000658-196701000-00014","article-title":"Cyanide production by Pseudomonas aeruginosa","volume":"165","author":"Goldfarb W. B.","year":"1967","unstructured":"Goldfarb W. B. Margraf H. Cyanide production by Pseudomonas aeruginosa.Ann. Surg.1651967104110","journal-title":"Ann. Surg."},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1094\/MPMI.2000.13.2.232","article-title":"Small, stable shuttle vectors based on the minimal pVS1 replicon for use in gram-negative, plant-associated bacteria","volume":"13","author":"Heeb S.","year":"2000","unstructured":"Heeb S. Itoh Y. Nishijyo T. Schnider U. Keel C. Wade J. Walsh U. O'Gara F. Haas D. Small, stable shuttle vectors based on the minimal pVS1 replicon for use in gram-negative, plant-associated bacteria.Mol. Plant-Microbe Interact.132000232237","journal-title":"Mol. Plant-Microbe Interact."},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","unstructured":"Holder\nI. A. Pseudomonas aeruginosa burn infections: pathogenesis and treatment\nPseudomonas aeruginosa as an opportunistic pathogen.\nCampa\nM.\nBendinelli\nM.\nFriedman\nH.\n1993\n275\n295\nPlenum Press\nNew York N.Y","DOI":"10.1007\/978-1-4615-3036-7_14"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/br.33.3.419-443.1969"},{"key":"e_1_3_2_33_2","first-page":"800","article-title":"pBBR1MCS: a broad-host-range cloning vector","volume":"16","author":"Kovach M. E.","year":"1994","unstructured":"Kovach M. E. Phillips R. W. Elzer P. H. Roop R. M. II Peterson K. M. pBBR1MCS: a broad-host-range cloning vector.BioTechniques161994800802","journal-title":"BioTechniques"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1046\/j.1365-2958.1996.00063.x","article-title":"A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhIR (VsmR) to expression of the stationary-phase sigma factor RpoS","volume":"21","author":"Latifi A.","year":"1996","unstructured":"Latifi A. Foglino M. Tanaka K. Williams P. Lazdunski A. A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhIR (VsmR) to expression of the stationary-phase sigma factor RpoS.Mol. Microbiol.21199611371146","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1365-2958.1995.mmi_17020333.x","article-title":"Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1","volume":"17","author":"Latifi A.","year":"1995","unstructured":"Latifi A. Winson M. K. Foglino M. Bycroft B. W. Stewart G. S. Lazdunski A. Williams P. Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1.Mol. Microbiol.171995333343","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.12.3187-3196.1998"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.8.2459-2464.1999"},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF00266910","article-title":"Chromosomal location of genes participating in the degradation of purines in Pseudomonas aeruginosa","volume":"167","author":"Matsumoto H.","year":"1978","unstructured":"Matsumoto H. Ohta S. Kobayashi R. Terawaki Y. Chromosomal location of genes participating in the degradation of purines in Pseudomonas aeruginosa.Mol. Gen. Genet.1671978165176","journal-title":"Mol. Gen. Genet."},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1094\/PHYTO.1998.88.7.678","article-title":"Salicylic acid biosynthetic genes expressed in Pseudomonas fluorescens strain P3 improve the induction of systemic resistance in tobacco against tobacco necrosis virus","volume":"88","author":"Maurhofer M.","year":"1998","unstructured":"Maurhofer M. Reimmann C. Schmidli-Sacherer P. Heeb S. Haas D. D\u00e9fago G. Salicylic acid biosynthetic genes expressed in Pseudomonas fluorescens strain P3 improve the induction of systemic resistance in tobacco against tobacco necrosis virus.Phytopathology881998678684","journal-title":"Phytopathology"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-143-12-3703"},{"key":"e_1_3_2_41_2","first-page":"193","article-title":"Modification of the overlap extension method for extensive mutagenesis on the same template","volume":"57","author":"Mikaelian I.","year":"1996","unstructured":"Mikaelian I. Sergeant A. Modification of the overlap extension method for extensive mutagenesis on the same template.Methods Mol. Biol.571996193202","journal-title":"Methods Mol. Biol."},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(84)90220-8"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.139.1.137-140.1979"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.7.2044-2054.1994"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.18.5756-5767.1997"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.10.3127-3132.1997"},{"key":"e_1_3_2_47_2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1046\/j.1365-2958.1997.3291701.x","article-title":"The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase","volume":"24","author":"Reimmann C.","year":"1997","unstructured":"Reimmann C. Beyeler M. Latifi A. Winteler H. Foglino M. Lazdunski A. Haas D. The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase.Mol. Microbiol.241997309319","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_48_2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S1369-5274(98)80005-2","article-title":"Positive activation of gene expression","volume":"1","author":"Rhodius V. A.","year":"1998","unstructured":"Rhodius V. A. Busby S. J. W. Positive activation of gene expression.Curr. Opin. Microbiol.11998152159","journal-title":"Curr. Opin. Microbiol."},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.11.5854-5862.1999"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.4.1134-1140.1996"},{"key":"e_1_3_2_51_2","unstructured":"Sambrook\nJ.\nFritsch\nE. F.\nManiatis\nT.\nMolecular cloning: a laboratory manual\n2nd ed.\n1989\nCold Spring Harbor Laboratory Press\nN.Y"},{"key":"e_1_3_2_52_2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/BF00279533","article-title":"Pseudomonas aeruginosa promoters which contain a conserved GG-N10-GC motif but appear to be RpoN-independent","volume":"238","author":"Savioz A.","year":"1993","unstructured":"Savioz A. Zimmermann A. Haas D. Pseudomonas aeruginosa promoters which contain a conserved GG-N10-GC motif but appear to be RpoN-independent.Mol. Gen. Genet.23819937480","journal-title":"Mol. Gen. Genet."},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.3.654-659.1995"},{"key":"e_1_3_2_54_2","unstructured":"Solomonson\nL. P.\nCyanide as a metabolic inhibitor\nCyanide in biology.\nVennesland\nB.\nConn\nE. E.\nKnowles\nC. J.\nWestley\nJ.\nWissing\nF.\n1981\n11\n28\nAcademic Press Ltd.\nLondon England"},{"key":"e_1_3_2_55_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF00871630","article-title":"The FNR family of transcriptional regulators","volume":"66","author":"Spiro S.","year":"1994","unstructured":"Spiro S. The FNR family of transcriptional regulators.Antonie Leeuwenhoek6619942336","journal-title":"Antonie Leeuwenhoek"},{"key":"e_1_3_2_56_2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00330442","article-title":"Characterisation of the hydroxystreptomycin phosphotransferase gene (sph) of Streptomyces glaucescens: nucleotide sequence and promoter analysis","volume":"208","author":"V\u00f6gtli M.","year":"1987","unstructured":"V\u00f6gtli M. H\u00fctter R. Characterisation of the hydroxystreptomycin phosphotransferase gene (sph) of Streptomyces glaucescens: nucleotide sequence and promoter analysis.Mol. Gen. Genet.2081987195203","journal-title":"Mol. Gen. Genet."},{"key":"e_1_3_2_57_2","doi-asserted-by":"crossref","unstructured":"Voisard\nC.\nBull\nC. T.\nKeel\nC.\nLaville\nJ.\nMaurhofer\nM.\nSchnider\nU.\nD\u00e9fago\nG.\nHaas\nD.\nBiocontrol of root diseases by Pseudomonas fluorescens CHA0: current concepts and experimental approaches\nMolecular ecology of rhizosphere microorganisms.\nO'Gara\nF.\nDowling\nD. N.\nBoesten\nB.\n1994\n67\n89\nVCH\nWeinheim Germany","DOI":"10.1002\/9783527615810.ch6"},{"key":"e_1_3_2_58_2","doi-asserted-by":"crossref","first-page":"13904","DOI":"10.1073\/pnas.96.24.13904","article-title":"Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa","volume":"96","author":"Whiteley M.","year":"1999","unstructured":"Whiteley M. Lee K. M. Greenberg E. P. Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa.Proc. Natl. Acad. Sci. USA9619991390413909","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_59_2","doi-asserted-by":"crossref","first-page":"9427","DOI":"10.1073\/pnas.92.20.9427","article-title":"Multiple N-acyl-l-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa","volume":"92","author":"Winson M. K.","year":"1995","unstructured":"Winson M. K. Camara M. Latifi A. Foglino M. Chhabra S. R. Daykin M. Bally M. Chapon V. Salmond G. P. Bycroft B. W. Lazdunski A. Stewart G. S. A. B. Williams P. Multiple N-acyl-l-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa.Proc. Natl. Acad. Sci. USA92199594279431","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_60_2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1099\/13500872-142-3-685","article-title":"The homologous regulators ANR of Pseudomonas aeruginosa and FNR of Escherichia coli have overlapping but distinct specificities for anaerobically inducible promoters","volume":"142","author":"Winteler H. V.","year":"1996","unstructured":"Winteler H. V. Haas D. The homologous regulators ANR of Pseudomonas aeruginosa and FNR of Escherichia coli have overlapping but distinct specificities for anaerobically inducible promoters.Microbiology1421996685693","journal-title":"Microbiology"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.62.9.3391-3398.1996"},{"key":"e_1_3_2_62_2","unstructured":"Wissing\nF.\nAndersen\nK. A.\nThe enzymology of cyanide production from glycine by a Pseudomonas species\nCyanide in biology.\nVennesland\nB.\nConn\nE. E.\nKnowles\nC. J.\nWestley\nJ.\nWissing\nF.\n1981\n275\n288\nAcademic Press Ltd.\nLondon England"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.12.3606-3609.1995"},{"key":"e_1_3_2_64_2","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1111\/j.1365-2958.1991.tb00794.x","article-title":"Anaerobic growth and cyanide synthesis of Pseudomonas aeruginosa depend on anr, a regulatory gene homologous with fnr of Escherichia coli","volume":"5","author":"Zimmerman A.","year":"1991","unstructured":"Zimmerman A. Reimmann C. Galimand M. Haas D. Anaerobic growth and cyanide synthesis of Pseudomonas aeruginosa depend on anr, a regulatory gene homologous with fnr of Escherichia coli.Mol. Microbiol.5199114831490","journal-title":"Mol. Microbiol."}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.182.24.6940-6949.2000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.182.24.6940-6949.2000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T13:55:52Z","timestamp":1627566952000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JB.182.24.6940-6949.2000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12,15]]},"references-count":63,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2000,12,15]]}},"alternative-id":["10.1128\/JB.182.24.6940-6949.2000"],"URL":"https:\/\/doi.org\/10.1128\/jb.182.24.6940-6949.2000","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,12,15]]},"assertion":[{"value":"2000-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-08-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}