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A 2,4-DAPG-negative Tn\n            <jats:italic>5<\/jats:italic>\n            insertion mutant of strain CHA0 was isolated, and the nucleotide sequence of the 4-kb genomic DNA region adjacent to the Tn\n            <jats:italic>5<\/jats:italic>\n            insertion site was determined. Four open reading frames were identified, two of which were homologous to\n            <jats:italic>phlA<\/jats:italic>\n            , the first gene of the 2,4-DAPG biosynthetic operon, and to the\n            <jats:italic>phlF<\/jats:italic>\n            gene encoding a pathway-specific transcriptional repressor. The Tn\n            <jats:italic>5<\/jats:italic>\n            insertion was located in an open reading frame, tentatively named\n            <jats:italic>phlH<\/jats:italic>\n            , which is not related to known\n            <jats:italic>phl<\/jats:italic>\n            genes. In wild-type CHA0, 2,4-DAPG production paralleled expression of a\n            <jats:italic>phlA\u2032-\u2032lacZ<\/jats:italic>\n            translational fusion, reaching a maximum in the late exponential growth phase. Thereafter, the compound appeared to be degraded to monoacetylphloroglucinol by the bacterium. 2,4-DAPG was identified as the active compound in extracts from culture supernatants of strain CHA0 specifically inducing\n            <jats:italic>phlA\u2032-\u2032lacZ<\/jats:italic>\n            expression about sixfold during exponential growth. Induction by exogenous 2,4-DAPG was most conspicuous in a\n            <jats:italic>phlA<\/jats:italic>\n            mutant, which was unable to produce 2,4-DAPG. In a\n            <jats:italic>phlF<\/jats:italic>\n            mutant, 2,4-DAPG production was enhanced severalfold and\n            <jats:italic>phlA\u2032-\u2032lacZ<\/jats:italic>\n            was expressed at a level corresponding to that in the wild type with 2,4-DAPG added. The\n            <jats:italic>phlF<\/jats:italic>\n            mutant was insensitive to 2,4-DAPG addition. A transcriptional\n            <jats:italic>phlA-lacZ<\/jats:italic>\n            fusion was used to demonstrate that the repressor PhlF acts at the level of transcription. Expression of\n            <jats:italic>phlA\u2032-\u2032lacZ<\/jats:italic>\n            and 2,4-DAPG synthesis in strain CHA0 was strongly repressed by the bacterial extracellular metabolites salicylate and pyoluteorin as well as by fusaric acid, a toxin produced by the pythopathogenic fungus\n            <jats:italic>Fusarium<\/jats:italic>\n            . In the\n            <jats:italic>phlF<\/jats:italic>\n            mutant, these compounds did not affect\n            <jats:italic>phlA\u2032-\u2032lacZ<\/jats:italic>\n            expression and 2,4-DAPG production. PhlF-mediated induction by 2,4-DAPG and repression by salicylate of\n            <jats:italic>phlA\u2032-\u2032lacZ<\/jats:italic>\n            expression was confirmed by using\n            <jats:italic>Escherichia coli<\/jats:italic>\n            as a heterologous host. In conclusion, our results show that autoinduction of 2,4-DAPG biosynthesis can be countered by certain bacterial (and fungal) metabolites. This mechanism, which depends on\n            <jats:italic>phlF<\/jats:italic>\n            function, may help\n            <jats:italic>P. fluorescens<\/jats:italic>\n            to produce homeostatically balanced amounts of extracellular metabolites.\n          <\/jats:p>","DOI":"10.1128\/jb.182.5.1215-1225.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:58:35Z","timestamp":1027763915000},"page":"1215-1225","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":309,"title":["Autoinduction of 2,4-Diacetylphloroglucinol Biosynthesis in the Biocontrol Agent\n            <i>Pseudomonas fluorescens<\/i>\n            CHA0 and Repression by the Bacterial Metabolites Salicylate and Pyoluteorin"],"prefix":"10.1128","volume":"182","author":[{"given":"Ursula","family":"Schnider-Keel","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne,1and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Seematter","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne,1and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Maurhofer","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Institut fu\u0308r Pflanzenwissenschaften\/Phytopathologie, Eidgeno\u0308ssische Technische Hochschule, CH-8092 Zu\u0308rich,2 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Blumer","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne,1and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brion","family":"Duffy","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Institut fu\u0308r Pflanzenwissenschaften\/Phytopathologie, Eidgeno\u0308ssische Technische Hochschule, CH-8092 Zu\u0308rich,2 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce\u0301cile","family":"Gigot-Bonnefoy","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne,1and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Reimmann","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne,1and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Notz","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Institut fu\u0308r Pflanzenwissenschaften\/Phytopathologie, Eidgeno\u0308ssische Technische Hochschule, CH-8092 Zu\u0308rich,2 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevie\u0300ve","family":"De\u0301fago","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Institut fu\u0308r Pflanzenwissenschaften\/Phytopathologie, Eidgeno\u0308ssische Technische Hochschule, CH-8092 Zu\u0308rich,2 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Haas","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne,1and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Keel","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne,1and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/br.36.4.525-557.1972"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.10.3155-3163.1999"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(91)90604-A"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1574-6941.1999.tb00578.x","article-title":"Enhanced production of indole-3-acetic acid by a genetically modified strain of Pseudomonas fluorescens CHA0 affects root growth of cucumber but does not improve protection of the plant against Pythium root rot","volume":"28","author":"Beyeler M.","year":"1999","unstructured":"Beyeler M. 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