{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T07:01:27Z","timestamp":1794639687534,"version":"4.9.1"},"reference-count":53,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2001,6,15]],"date-time":"2001-06-15T00:00:00Z","timestamp":992563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2001,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The purpose of this study was to determine the bacterial diversity in the human subgingival plaque by using culture-independent molecular methods as part of an ongoing effort to obtain full 16S rRNA sequences for all cultivable and not-yet-cultivated species of human oral bacteria. Subgingival plaque was analyzed from healthy subjects and subjects with refractory periodontitis, adult periodontitis, human immunodeficiency virus periodontitis, and acute necrotizing ulcerative gingivitis. 16S ribosomal DNA (rDNA) bacterial genes from DNA isolated from subgingival plaque samples were PCR amplified with all-bacterial or selective primers and cloned into\n            <jats:italic>Escherichia coli<\/jats:italic>\n            . The sequences of cloned 16S rDNA inserts were used to determine species identity or closest relatives by comparison with sequences of known species. A total of 2,522 clones were analyzed. Nearly complete sequences of approximately 1,500 bases were obtained for putative new species. About 60% of the clones fell into 132 known species, 70 of which were identified from multiple subjects. About 40% of the clones were novel phylotypes. Of the 215 novel phylotypes, 75 were identified from multiple subjects. Known putative periodontal pathogens such as\n            <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n            ,\n            <jats:italic>Bacteroides forsythus<\/jats:italic>\n            , and\n            <jats:italic>Treponema denticola<\/jats:italic>\n            were identified from multiple subjects, but typically as a minor component of the plaque as seen in cultivable studies. Several phylotypes fell into two recently described phyla previously associated with extreme natural environments, for which there are no cultivable species. A number of species or phylotypes were found only in subjects with disease, and a few were found only in healthy subjects. The organisms identified only from diseased sites deserve further study as potential pathogens. Based on the sequence data in this study, the predominant subgingival microbial community consisted of 347 species or phylotypes that fall into 9 bacterial phyla. Based on the 347 species seen in our sample of 2,522 clones, we estimate that there are 68 additional unseen species, for a total estimate of 415 species in the subgingival plaque. When organisms found on other oral surfaces such as the cheek, tongue, and teeth are added to this number, the best estimate of the total species diversity in the oral cavity is approximately 500 species, as previously proposed.\n          <\/jats:p>","DOI":"10.1128\/jb.183.12.3770-3783.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:01:09Z","timestamp":1027764069000},"page":"3770-3783","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1618,"title":["Bacterial Diversity in Human Subgingival Plaque"],"prefix":"10.1128","volume":"183","author":[{"given":"Bruce J.","family":"Paster","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Molecular Genetics, The Forsyth Institute,1 and"},{"name":"<!--label omitted: 2-->Department of Oral Biology, Harvard School of Dental Medicine,2 Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"Boches","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Molecular Genetics, The Forsyth Institute,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie L.","family":"Galvin","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Molecular Genetics, The Forsyth Institute,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E.","family":"Ericson","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Molecular Genetics, The Forsyth Institute,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol N.","family":"Lau","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Molecular Genetics, The Forsyth Institute,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie A.","family":"Levanos","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Molecular Genetics, The Forsyth Institute,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Sahasrabudhe","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Molecular Genetics, The Forsyth Institute,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floyd E.","family":"Dewhirst","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Molecular Genetics, The Forsyth Institute,1 and"},{"name":"<!--label omitted: 2-->Department of Oral Biology, Harvard School of Dental Medicine,2 Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1128\/MR.59.1.143-169.1995","article-title":"Phylogenetic identification and in situ detection of individual microbial cells without cultivation","volume":"59","author":"Amman R.","year":"1995","unstructured":"Amman R. Ludwig W. Schleifer K.-H. Phylogenetic identification and in situ detection of individual microbial cells without cultivation.Microbiol. Rev.591995143169","journal-title":"Microbiol. Rev."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1902\/jop.1996.67.10s.1123","article-title":"Periodontal disease and cardiovascular disease","volume":"67","author":"Beck J.","year":"1996","unstructured":"Beck J. Garcia R. Heiss G. Vokonas P. S. Offenbacher S. Periodontal disease and cardiovascular disease.J. Periodontol.67199611231137","journal-title":"J. Periodontol."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"532","DOI":"10.4065\/72.6.532","article-title":"Infective endocarditis due to unusual or fastidious microorganisms","volume":"72","author":"Berbari E. F.","year":"1997","unstructured":"Berbari E. F. Cockerill F. R. III Steckelberg J. M. Infective endocarditis due to unusual or fastidious microorganisms.Mayo Clin. Proc.721997532542","journal-title":"Mayo Clin. Proc."},{"key":"e_1_3_2_5_2","first-page":"396","article-title":"Cultivable and uncultivable bacteria on the healthy tongue dorsum","volume":"79","author":"Boches S. K.","year":"2000","unstructured":"Boches S. K. Mitchell P. M. Galvin J. L. Loesche W. J. Kazor C. E. Dewhirst F. E. Paster B. J. Cultivable and uncultivable bacteria on the healthy tongue dorsum.J. Dent. Res.792000396","journal-title":"J. Dent. Res."},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1080\/01621459.1998.10474118","article-title":"Estimating the prediction function and the number of unseen species in sampling with replacement","volume":"93","author":"Boneh S.","year":"1998","unstructured":"Boneh S. Boneh A. Caron R. J. Estimating the prediction function and the number of unseen species in sampling with replacement.J. Am. Statist. Assoc.931998372379","journal-title":"J. Am. Statist. Assoc."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.5.1889-1895.1994"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1007\/BF02100146","article-title":"Antagonistic effects of sulfide and butyrate on proliferation of colonic mucosa: a potential role for these agents in the pathogenesis of ulcerative colitis","volume":"41","author":"Christl S. U.","year":"1996","unstructured":"Christl S. U. Eisner H. D. Dusel G. Kasper H. Scheppach W. Antagonistic effects of sulfide and butyrate on proliferation of colonic mucosa: a potential role for these agents in the pathogenesis of ulcerative colitis.Dig. Dis. Sci.41199624772481","journal-title":"Dig. Dis. Sci."},{"key":"e_1_3_2_9_2","first-page":"207","article-title":"Identification of 16S rRNA clones from a subject with ANUG as Atopobium species","volume":"75","author":"Coleman B. E.","year":"1996","unstructured":"Coleman B. E. Tzellas N. Paster B. J. Dewhirst F. E. Identification of 16S rRNA clones from a subject with ANUG as Atopobium species.J. Dent. Res.751996207","journal-title":"J. Dent. Res."},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1034\/j.1399-302x.2000.150308.x","article-title":"The diversity of periodontal spirochetes by 16S rRNA analysis","volume":"15","author":"Dewhirst F. E.","year":"2000","unstructured":"Dewhirst F. E. Tamer M. A. Ericson R. E. Lau C. N. Levanos V. A. Boches S. K. Galvin J. L. Paster B. J. The diversity of periodontal spirochetes by 16S rRNA analysis.Oral Microbiol. Immunol.152000196202","journal-title":"Oral Microbiol. Immunol."},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1440-1754.2000.00447.x","article-title":"Kingella kingae infections in children","volume":"36","author":"Dodman T.","year":"2000","unstructured":"Dodman T. Robson J. Pincus D. Kingella kingae infections in children.J. Paediatr. Child Health3620008790","journal-title":"J. Paediatr. Child Health"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.3.537-542.1996"},{"key":"e_1_3_2_13_2","first-page":"435","article-title":"Estimating the number of unseen species. How many words did Shakespeare know?","volume":"63","author":"Efron B.","year":"1976","unstructured":"Efron B. Thisted R. Estimating the number of unseen species. How many words did Shakespeare know? Biometrika 63 1976 435 447","journal-title":"Biometrika"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2307\/1411"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1099\/00207713-42-1-166","article-title":"How close is close: 16S rRNA sequence identity may not be sufficient to guarantee species identity","volume":"42","author":"Fox G. E.","year":"1992","unstructured":"Fox G. E. Wisotzkey J. D. Jurtshuk P. Jr. How close is close: 16S rRNA sequence identity may not be sufficient to guarantee species identity.Int. J. Syst. Bacteriol.421992166170","journal-title":"Int. J. Syst. Bacteriol."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"S177","DOI":"10.1093\/clinids\/6.Supplement_1.S177","article-title":"Role of anaerobic bacteria in bite-wound infections","volume":"6","author":"Goldstein E. J.","year":"1984","unstructured":"Goldstein E. J. Citron D. M. Finegold S. M. Role of anaerobic bacteria in bite-wound infections.Rev. Infect. Dis.61984S177S183","journal-title":"Rev. Infect. Dis."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/clinids\/10.2.317","article-title":"Erysipelothrix rhusiopathiae endocarditis: microbiologic, epidemiologic, and clinical features of an occupational disease","volume":"10","author":"Gorby G. L.","year":"1988","unstructured":"Gorby G. L. Peacock J. E. Jr. Erysipelothrix rhusiopathiae endocarditis: microbiologic, epidemiologic, and clinical features of an occupational disease.Rev. Infect. Dis.101988317325","journal-title":"Rev. Infect. Dis."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.5.1469-1473.1999"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0167-7799(96)10025-1","article-title":"Identifying microbial diversity in the natural environment: a molecular phylogenetic approach","volume":"14","author":"Hugenholtz P.","year":"1996","unstructured":"Hugenholtz P. Pace N. R. Identifying microbial diversity in the natural environment: a molecular phylogenetic approach.Trends Biotechnol.141996190197","journal-title":"Trends Biotechnol."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.2.366-376.1998"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/B978-1-4832-3211-9.50009-7","article-title":"Evolution of protein molecules","volume":"3","author":"Jukes T. H.","year":"1969","unstructured":"Jukes T. H. Cantor C. R. Evolution of protein molecules Mammalian protein metabolism Munro H. N. 3 1969 21 132 Academic Press, Inc. New York, N.Y","journal-title":"Mammalian protein metabolism"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"14547","DOI":"10.1073\/pnas.96.25.14547","article-title":"Bacterial diversity within the human subgingival crevice","volume":"96","author":"Kroes I.","year":"1999","unstructured":"Kroes I. Lepp P. W. Relman D. A. Bacterial diversity within the human subgingival crevice.Proc. Natl. Acad. Sci. USA9619991454714552","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_23_2","first-page":"139","article-title":"Cultivable and uncultivable predominant bacterial species in refractory periodontitis","volume":"77","author":"Lau C. N.","year":"1998","unstructured":"Lau C. N. Paster B. J. Levanos V. Ericson R. L. Dewhirst F. E. Cultivable and uncultivable predominant bacterial species in refractory periodontitis.J. Dent. Res.771998139","journal-title":"J. Dent. Res."},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1006\/mcpr.1994.1017","article-title":"Evaluation of the detection limits of PCR for identification of Mycoplasma pneumoniae in clinical samples","volume":"8","author":"Leng Z.","year":"1994","unstructured":"Leng Z. Kenny G. E. Roberts M. C. Evaluation of the detection limits of PCR for identification of Mycoplasma pneumoniae in clinical samples.Mol. Cell. Probes81994125130","journal-title":"Mol. Cell. Probes"},{"key":"e_1_3_2_25_2","first-page":"234","article-title":"Predominant cultivable and uncultivable bacterial species in adult periodontitis","volume":"79","author":"Levanos V. A.","year":"2000","unstructured":"Levanos V. A. Galvin J. L. Boches S. K. Dewhirst F. E. Paster B. J. Predominant cultivable and uncultivable bacterial species in adult periodontitis.J. Dent. Res.792000234","journal-title":"J. Dent. Res."},{"key":"e_1_3_2_26_2","first-page":"453","article-title":"Cultivable and uncultivable species on or in gingival epithelial cells","volume":"78","author":"Levin I. M.","year":"1999","unstructured":"Levin I. M. Lau C. N. Socransky S. S. Haffajee A. D. Martin L. Galvin J. L. Boches S. K. Paster B. J. Dewhirst F. E. Cultivable and uncultivable species on or in gingival epithelial cells.J. Dent. Res.781999453","journal-title":"J. Dent. Res."},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF02539153","article-title":"Potential risk of gene amplification by PCR as determined by 16S rDNA analysis of a mixed-culture of strict barophilic bacteria","volume":"21","author":"Liesack W.","year":"1991","unstructured":"Liesack W. Weyland H. Stackebrandt E. Potential risk of gene amplification by PCR as determined by 16S rDNA analysis of a mixed-culture of strict barophilic bacteria.Microbiol. Ecol.211991191198","journal-title":"Microbiol. Ecol."},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1574-6968.1991.tb04432.x","article-title":"A novel eubacterial phylum: comparative nucleotide sequence analysis of a tuf-gene of Flexistipes sinusarabici","volume":"62","author":"Ludwig W.","year":"1991","unstructured":"Ludwig W. Wallner G. Tesch A. Klink F. A novel eubacterial phylum: comparative nucleotide sequence analysis of a tuf-gene of Flexistipes sinusarabici.FEMS Microbiol. Lett.621991139143","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/nar\/28.1.173","article-title":"The RDP (Ribosomal Database Project) continues","volume":"28","author":"Maidak B. L.","year":"2000","unstructured":"Maidak B. L. Cole J. R. Lilburn T. G. Parker C. T. Jr. Saxman P. R. Stredwick J. M. Garrity G. M. Li B. Olsen G. J. Pramanik S. Schmidt T. M. Tiedje J. M. The RDP (Ribosomal Database Project) continues.Nucleic Acids Res.282000173174","journal-title":"Nucleic Acids Res."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.7.1.25-30.2000"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF00250272","article-title":"Amino acid utilization by the ruminal bacterium Synergistes jonesii strain 78\u20131","volume":"159","author":"McSweeny C. S.","year":"1993","unstructured":"McSweeny C. S. Allison M. J. Mackie R. I. Amino acid utilization by the ruminal bacterium Synergistes jonesii strain 78\u20131.Arch. Microbiol.1591993131135","journal-title":"Arch. Microbiol."},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1099\/00207713-44-2-187","article-title":"Oribaculum catoniae gen. nov., sp. nov.; Catonella morbi gen. nov., sp. nov.; Hallella seregens gen. nov., sp. nov.; Johnsonella ignava gen. nov., sp. nov.; and Dialister pneumosintes gen. nov., comb. nov., nom. rev., anaerobic gram-negative bacilli from the human gingival crevice","volume":"44","author":"Moore L. V.","year":"1994","unstructured":"Moore L. V. Moore W. E. C. Oribaculum catoniae gen. nov., sp. nov.; Catonella morbi gen. nov., sp. nov.; Hallella seregens gen. nov., sp. nov.; Johnsonella ignava gen. nov., sp. nov.; and Dialister pneumosintes gen. nov., comb. nov., nom. rev., anaerobic gram-negative bacilli from the human gingival crevice.Int. J. Syst. Bacteriol.441994187192","journal-title":"Int. J. Syst. Bacteriol."},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1600-0757.1994.tb00019.x","article-title":"The bacteria of periodontal diseases","volume":"5","author":"Moore W. E. C.","year":"1994","unstructured":"Moore W. E. C. Moore L. V. H The bacteria of periodontal diseases.Periodontol. 2000519946677","journal-title":"Periodontol. 2000"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1902\/annals.1998.3.1.233","article-title":"Potential pathogenic mechanisms of periodontitis associated pregnancy complications","volume":"3","author":"Offenbacher S.","year":"1998","unstructured":"Offenbacher S. Jared H. L. O'Reilly P. G. Wells S. R. Salvi G. E. Lawrence H. P. Socransky S. S. Beck J. D. Potential pathogenic mechanisms of periodontitis associated pregnancy complications.Ann. Periodontol.31998233250","journal-title":"Ann. Periodontol."},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4757-0611-6_1","article-title":"The analysis of natural microbial populations by ribosomal RNA sequences","volume":"9","author":"Pace N. R.","year":"1986","unstructured":"Pace N. R. Stahl D. A. Lane D. J. Olsen G. J. The analysis of natural microbial populations by ribosomal RNA sequences.Adv. Microb. Ecol.91986155","journal-title":"Adv. Microb. Ecol."},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1023\/A:1009715710555","article-title":"Identification of oral streptococci using PCR-based, reverse-capture, checkerboard hybridization","volume":"20","author":"Paster B. J.","year":"1998","unstructured":"Paster B. J. Bartoszyk I. M. Dewhirst F. E. Identification of oral streptococci using PCR-based, reverse-capture, checkerboard hybridization.Methods Cell Sci.201998223231","journal-title":"Methods Cell Sci."},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1099\/00207713-38-1-56","article-title":"Phylogeny of campylobacters, wolinellas, Bacteroides gracilis, and Bacteroides ureolyticus by 16S rRNA sequencing","volume":"38","author":"Paster B. J.","year":"1988","unstructured":"Paster B. J. Dewhirst F. E. Phylogeny of campylobacters, wolinellas, Bacteroides gracilis, and Bacteroides ureolyticus by 16S rRNA sequencing.Int. J. Syst. Bacteriol.3819885662","journal-title":"Int. J. Syst. Bacteriol."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.19.6101-6109.1991"},{"key":"e_1_3_2_39_2","first-page":"159","article-title":"A molecular approach to search for diversity among bacteria in the environment","volume":"17","author":"Rheims H.","year":"1996","unstructured":"Rheims H. Rainey F. A. Stackebrandt E. A molecular approach to search for diversity among bacteria in the environment.J. Ind. Microbiol.171996159169","journal-title":"J. Ind. Microbiol."},{"key":"e_1_3_2_40_2","first-page":"167","article-title":"Bacterial species and phylotypes in necrotizing ulcerative periodontitis","volume":"80","author":"Russell M. K.","year":"2001","unstructured":"Russell M. K. Alpagot T. Boches S. K. Galvin J. L. Dewhirst F. E. Paster B. J. Bacterial species and phylotypes in necrotizing ulcerative periodontitis.J. Dent. Res.802001167","journal-title":"J. Dent. Res."},{"key":"e_1_3_2_41_2","first-page":"406","article-title":"The neighbor-joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"Saitou N.","year":"1987","unstructured":"Saitou N. Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees.Mol. Biol. Evol.41987406425","journal-title":"Mol. Biol. Evol."},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1348-0421.2000.tb02545.x","article-title":"Comparison of the oral bacterial flora in saliva from a healthy subject and two periodontitis patients by sequence analysis of 16S rDNA libraries","volume":"44","author":"Sakamoto M.","year":"2000","unstructured":"Sakamoto M. Umeda M. Ishikawa I. Benno Y. Comparison of the oral bacterial flora in saliva from a healthy subject and two periodontitis patients by sequence analysis of 16S rDNA libraries.Microbiol. Immunol.442000643652","journal-title":"Microbiol. Immunol."},{"key":"e_1_3_2_43_2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1902\/jop.1999.70.7.793","article-title":"Role of oral bacteria in respiratory infection","volume":"70","author":"Scannapieco F. A.","year":"1999","unstructured":"Scannapieco F. A. Role of oral bacteria in respiratory infection.J. Periodontol.701999793802","journal-title":"J. Periodontol."},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1994.tb00016.x"},{"key":"e_1_3_2_45_2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky S. S.","year":"1998","unstructured":"Socransky S. S. Haffajee A. D. Cugini M. A. Smith C. Kent R. L. Jr. Microbial complexes in subgingival plaque.J. Clin. Periodontol.251998134144","journal-title":"J. Clin. Periodontol."},{"key":"e_1_3_2_46_2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1034\/j.1399-302X.1999.140107.x","article-title":"Diversity of oral asaccharolytic Eubacterium species in periodontitis: identification of novel phylotypes representing uncultivated taxa","volume":"14","author":"Spratt D. A.","year":"1999","unstructured":"Spratt D. A. Weightman A. J. Wade W. G. Diversity of oral asaccharolytic Eubacterium species in periodontitis: identification of novel phylotypes representing uncultivated taxa.Oral Microbiol. Immunol.1419995659","journal-title":"Oral Microbiol. Immunol."},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-44-4-846"},{"key":"e_1_3_2_48_2","first-page":"569","article-title":"TREECON for Windows: a software package for the construction and drawing of evolutionary trees for the Microsoft Windows environment","volume":"10","author":"Van de Peer Y.","year":"1994","unstructured":"Van de Peer Y. De Wachter R. TREECON for Windows: a software package for the construction and drawing of evolutionary trees for the Microsoft Windows environment.Comput. Appl. Biosci.101994569570","journal-title":"Comput. Appl. Biosci."},{"key":"e_1_3_2_49_2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1399-302X.1995.tb00156.x","article-title":"Sulfate-reducing bacteria in the periodontal pocket","volume":"10","author":"van der Hoeven J. S.","year":"1995","unstructured":"van der Hoeven J. S. van den Kieboom C. W. Schaeken M. J. Sulfate-reducing bacteria in the periodontal pocket.Oral Microbiol. Immunol.101995288290","journal-title":"Oral Microbiol. Immunol."},{"key":"e_1_3_2_50_2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0099-2399(06)80843-5","article-title":"Porphyromonas (Bacteroides) endodontalis: its role in endodontal infections","volume":"18","author":"van Winkelhoff A. J.","year":"1992","unstructured":"van Winkelhoff A. J. van Steenbergen T. J. de Graaff J. Porphyromonas (Bacteroides) endodontalis: its role in endodontal infections.J. Endod.181992431434","journal-title":"J. Endod."},{"key":"e_1_3_2_51_2","doi-asserted-by":"crossref","first-page":"S235","DOI":"10.1086\/516215","article-title":"Molecular detection of novel anaerobic species in dentoalveolar abscesses","volume":"25","author":"Wade W. G.","year":"1997","unstructured":"Wade W. G. Spratt D. A. Dymock D. Weightman A. J. Molecular detection of novel anaerobic species in dentoalveolar abscesses.Clin. Infect. Dis.251997S235S236","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_52_2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1699-0463.1991.tb05121.x","article-title":"Fatal septicaemia with Selenomonas sputigena and Acinetobacter calcoaceticus. A case report","volume":"99","author":"Westh H.","year":"1991","unstructured":"Westh H. Christensen J. J. Blom J. Frederiksen W. Fatal septicaemia with Selenomonas sputigena and Acinetobacter calcoaceticus. A case report.APMIS9919917577","journal-title":"APMIS"},{"key":"e_1_3_2_53_2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00013542-199704000-00005","article-title":"Applications of molecular ecology in the characterisation of uncultured microorganisms associated with human disease","volume":"8","author":"Wilson M. J.","year":"1997","unstructured":"Wilson M. J. Weightman A. J. Wade W. G. Applications of molecular ecology in the characterisation of uncultured microorganisms associated with human disease.Rev. Med. Microbiol.8199791101","journal-title":"Rev. Med. Microbiol."},{"key":"e_1_3_2_54_2","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1001\/archinte.160.18.2749","article-title":"Periodontal disease and risk of cerebrovascular disease: the first national health and nutrition examination survey and its follow-up study","volume":"160","author":"Wu T.","year":"2000","unstructured":"Wu T. Trevisan M. Genco R. J. Dorn J. P. Falkner K. L. Sempos C. T. Periodontal disease and risk of cerebrovascular disease: the first national health and nutrition examination survey and its follow-up study.Arch. Intern. Med.160200027492755","journal-title":"Arch. Intern. Med."}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.183.12.3770-3783.2001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.183.12.3770-3783.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T17:58:13Z","timestamp":1627581493000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JB.183.12.3770-3783.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6,15]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2001,6,15]]}},"alternative-id":["10.1128\/JB.183.12.3770-3783.2001"],"URL":"https:\/\/doi.org\/10.1128\/jb.183.12.3770-3783.2001","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6,15]]},"assertion":[{"value":"2000-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-03-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}