{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:26:07Z","timestamp":1791419167841,"version":"4.3.3"},"reference-count":59,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2001,1,15]],"date-time":"2001-01-15T00:00:00Z","timestamp":979516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2001,1,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    genome encodes three ferric uptake repressor (Fur) homologues: Fur, PerR, and Zur. To determine the exact role of Fur in\n                    <jats:italic>S. aureus<\/jats:italic>\n                    , we inactivated the\n                    <jats:italic>fur<\/jats:italic>\n                    gene by allelic replacement using a tetracycline resistance cassette, creating strain MJH010 (\n                    <jats:italic>fur<\/jats:italic>\n                    ). The mutant had a growth defect in rich medium, and this defect was exacerbated in metal-depleted CL medium. This growth defect was partially suppressed by manganous ion, a metal ion with known antioxidant properties. This suggests that the\n                    <jats:italic>fur<\/jats:italic>\n                    mutation leads to an oxidative stress condition. Indeed, MJH010 (\n                    <jats:italic>fur<\/jats:italic>\n                    ) has reduced levels of catalase activity resulting from decreased\n                    <jats:italic>katA<\/jats:italic>\n                    transcription. Using a\n                    <jats:italic>katA-lacZ<\/jats:italic>\n                    fusion we have determined that Fur functions, either directly or indirectly, as an iron-dependent positive regulator of\n                    <jats:italic>katA<\/jats:italic>\n                    expression. Transcription of\n                    <jats:italic>katA<\/jats:italic>\n                    is coregulated by Fur and PerR, since in MJH010 (\n                    <jats:italic>fur<\/jats:italic>\n                    ) transcription was still repressed by manganese while transcription in MJH201 (\n                    <jats:italic>fur perR<\/jats:italic>\n                    ) was unresponsive to the presence of iron or manganese. Siderophore biosynthesis was repressed by iron in 8325-4 (wild-type) but in MJH010 (\n                    <jats:italic>fur<\/jats:italic>\n                    ) was constitutive. A number of putative Fur-regulated genes were identified in the incomplete genome databases using known\n                    <jats:italic>S. aureus<\/jats:italic>\n                    Fur box sequences. Of those tested, the\n                    <jats:italic>sstABCD<\/jats:italic>\n                    and\n                    <jats:italic>sirABC<\/jats:italic>\n                    operons and the\n                    <jats:italic>fhuD2<\/jats:italic>\n                    and\n                    <jats:italic>orf4<\/jats:italic>\n                    genes were found to have Fur-regulated expression. MJH010 (\n                    <jats:italic>fur<\/jats:italic>\n                    ) was attenuated (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.04) in a murine skin abscess model of infection, as was double-mutant MJH201 (\n                    <jats:italic>fur perR<\/jats:italic>\n                    ) (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.03). This demonstrates the importance in vivo of iron homeostasis and oxidative stress resistance regulation in\n                    <jats:italic>S. aureus.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1128\/jb.183.2.468-475.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:01:09Z","timestamp":1027749669000},"page":"468-475","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":290,"title":["In\n                    <i>Staphylococcus aureus<\/i>\n                    , Fur Is an Interactive Regulator with PerR, Contributes to Virulence, and Is Necessary for Oxidative Stress Resistance through Positive Regulation of Catalase and Iron Homeostasis"],"prefix":"10.1128","volume":"183","author":[{"given":"Malcolm J.","family":"Horsburgh","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Ingham","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Microbiology, University of Leeds, Leeds,2England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Foster","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1046\/j.1365-2958.1998.00790.x","article-title":"Metal ion homeostasis and intracellular parasitism","volume":"8","author":"Agranoff D. D.","year":"1998","unstructured":"Agranoff D. D. Krishna S. Metal ion homeostasis and intracellular parasitism.Mol. Microbiol.81998403412","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.22.6571-6578.1996"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.145.1.442-451.1981"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1021\/bi00391a039","article-title":"Ferric uptake regulation protein acts as a repressor, employing iron (II) as a cofactor to bind the operator of an iron transport operon in Escherichia coli","volume":"26","author":"Bagg A.","year":"1987","unstructured":"Bagg A. Neilands J. B. Ferric uptake regulation protein acts as a repressor, employing iron (II) as a cofactor to bind the operator of an iron transport operon in Escherichia coli.Biochemistry26198754715477","journal-title":"Biochemistry"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50881-X"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/ajcn\/30.8.1236","article-title":"Magnitude of the host nutritional responses to infection","volume":"30","author":"Beisel W. R.","year":"1977","unstructured":"Beisel W. R. Magnitude of the host nutritional responses to infection.Am. J. Clin. Nutr.30197712361247","journal-title":"Am. J. Clin. Nutr."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1073\/pnas.87.1.389","article-title":"Manganese (II) catalyses the bicarbonate-dependent oxidation of amino acids by hydrogen peroxide and the amino acid-facilitated dismutation of hydrogen peroxide","volume":"87","author":"Berlett B. S.","year":"1990","unstructured":"Berlett B. S. Chock P. B. Yim M. B. Stadtman E. R. Manganese (II) catalyses the bicarbonate-dependent oxidation of amino acids by hydrogen peroxide and the amino acid-facilitated dismutation of hydrogen peroxide.Proc. Natl. Acad. Sci. USA871990389393","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and quantitative method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford M. M.","year":"1976","unstructured":"Bradford M. M. A rapid and quantitative method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.Anal. Biochem.721976248254","journal-title":"Anal. Biochem."},{"key":"e_1_3_2_10_2","first-page":"67","article-title":"Bacterial iron transport: mechanisms, genetics, and regulation","volume":"35","author":"Braun V.","year":"1998","unstructured":"Braun V. Hantke K. Koster W. Bacterial iron transport: mechanisms, genetics, and regulation.Met. Ions Biol. Syst.35199867145","journal-title":"Met. Ions Biol. Syst."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.22.6579-6586.1996"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1046\/j.1365-2958.1998.00921.x","article-title":"Bacillus subtilis contains multiple Fur homologues: identification of the iron uptake (Fur) and peroxide regulon (PerR) repressors","volume":"29","author":"Bsat N.","year":"1998","unstructured":"Bsat N. Herbig A. Casillas-Martinez L. Setlow P. Helmann J. D. Bacillus subtilis contains multiple Fur homologues: identification of the iron uptake (Fur) and peroxide regulon (PerR) repressors.Mol. Microbiol.291998189198","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.14.4299-4307.1999"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.174.2.568-574.1992"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.23.6232-6241.1998"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.13.3898-3903.1999"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1365-2958.1994.tb01320.x","article-title":"Iron piracy: acquisition of transferrin-bound iron by bacterial pathogens","volume":"14","author":"Cornelissen C. N.","year":"1994","unstructured":"Cornelissen C. N. Sparling P. F. Iron piracy: acquisition of transferrin-bound iron by bacterial pathogens.Mol. Microbiol.141994843850","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.5.1944-1948.1997"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1574-6968.1999.tb13556.x","article-title":"Characterization of a new operon encoding a Zur-like protein and an associated ABC zinc permease in Listeria monocytogenes","volume":"170","author":"Dalet K.","year":"1999","unstructured":"Dalet K. Gouin E. Cenatiempo Y. Cossart P. Hechard Y. Characterization of a new operon encoding a Zur-like protein and an associated ABC zinc permease in Listeria monocytogenes.FEMS Microbiol. Lett.1701999111116","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_2_20_2","first-page":"185","article-title":"Purification and characterisation of staphyloferrin B, a hydrophilic siderophore from staphylococci","volume":"6","author":"Dreschel H.","year":"1993","unstructured":"Dreschel H. Freund S. Nicholson G. Haag H. Jung O. Zahner H. Jung G. Purification and characterisation of staphyloferrin B, a hydrophilic siderophore from staphylococci.Biometals61993185192","journal-title":"Biometals"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.13.3802-3808.2000"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.20.6223-6229.1999"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"23471","DOI":"10.1016\/S0021-9258(17)31540-5","article-title":"Stable Mn (III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo","volume":"269","author":"Faulkner K. M.","year":"1994","unstructured":"Faulkner K. M. Liochev S. I. Fridovich I. Stable Mn (III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo.J. Biol. Chem.26919942347123476","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.22.5815-5821.1998"},{"key":"e_1_3_2_25_2","unstructured":"Griffiths\nE.\nThe iron-uptake systems of pathogenic bacteria\nIron and infection: molecular physiological and clinical aspects.\nBullen\nJ. J.\nGriffiths\nE.\n1987\n69\n138\nJohn Wiley & Sons\nChichester United Kingdom"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0378-1119(95)00652-4","article-title":"Antibiotic resistance cassettes for Bacillus subtilis","volume":"167","author":"Guerot-Fleury A.-M.","year":"1995","unstructured":"Guerot-Fleury A.-M. Shazand K. Frandsen N. Stragier P. Antibiotic resistance cassettes for Bacillus subtilis.Gene1671995335336","journal-title":"Gene"},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1574-6968.1994.tb06626.x","article-title":"Isolation and characterisation of staphyloferrin B, a compound with siderophore activity from staphylococci","volume":"115","author":"Haag H.","year":"1994","unstructured":"Haag H. Fiedler H. P. Meiwes J. Zahner H. Isolation and characterisation of staphyloferrin B, a compound with siderophore activity from staphylococci.FEMS Microbiol. Lett.1151994125130","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00337769","article-title":"Selection procedure for downregulated iron transport mutants (fur) in Escherichia coli K-12: fur not only affects iron metabolism","volume":"210","author":"Hantke K.","year":"1987","unstructured":"Hantke K. Selection procedure for downregulated iron transport mutants (fur) in Escherichia coli K-12: fur not only affects iron metabolism.Mol. Gen. Genet.2101987135139","journal-title":"Mol. Gen. Genet."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.5.1436-1443.1999"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.58.1.26-31.1990"},{"key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.2834821","article-title":"Toxic DNA damage through the Fenton reaction in vivo and in vitro","volume":"240","author":"Imlay J.","year":"1988","unstructured":"Imlay J. Linn S. Toxic DNA damage through the Fenton reaction in vivo and in vitro.Science2401988640642","journal-title":"Science"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.4.2924"},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1432-1033.1990.tb19094.x","article-title":"Staphyloferrin A: a structurally new siderophore from staphylococci","volume":"191","author":"Konnetschy-Rapp S.","year":"1991","unstructured":"Konnetschy-Rapp S. Jung G. Meiwes J. Zahner H. Staphyloferrin A: a structurally new siderophore from staphylococci.Eur. J. Biochem.19119916574","journal-title":"Eur. J. Biochem."},{"key":"e_1_3_2_34_2","unstructured":"Kornblum\nJ.\nKreisworth\nB. N.\nProjan\nS. J.\nRoss\nH.\nNovick\nR. P. agr : a polycistronic locus regulating exoprotein synthesis in Staphylococcus aureus Molecular biology of the staphylococci.\nNovick\nR. P.\n1990\n373\n402\nVCH Publishers\nNew York N.Y"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.6.2309-2314.1994"},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1574-6968.1990.tb13863.x","article-title":"Isolation and characterisation of staphyloferrin A, a compound with siderophore activity from Staphylococcus hyicus DSM 20459","volume":"67","author":"Meiwes J.","year":"1990","unstructured":"Meiwes J. Fiedler H. P. Zahner H. Konnetschy-Rapp S. Jung G. Isolation and characterisation of staphyloferrin A, a compound with siderophore activity from Staphylococcus hyicus DSM 20459.FEMS Microbiol. Lett.671990201206","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.8.3591-3596.1998"},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1128\/IAI.67.3.1086-1092.1999","article-title":"The staphylococcal transferrin-binding protein is a cell wall glyceraldehyde-3-phosphate dehydrogenase","volume":"67","author":"Modun B.","year":"1999","unstructured":"Modun B. Williams P. The staphylococcal transferrin-binding protein is a cell wall glyceraldehyde-3-phosphate dehydrogenase.Infect. Immun.67199910861092","journal-title":"Infect. Immun."},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0966-842X(00)01728-5","article-title":"The staphylococcal transferrin receptor: a glycolytic enzyme with novel functions","volume":"8","author":"Modun B.","year":"2000","unstructured":"Modun B. Morrissey J. Williams P. The staphylococcal transferrin receptor: a glycolytic enzyme with novel functions.Trends Microbiol.82000231237","journal-title":"Trends Microbiol."},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.4.1930-1938.1990"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(91)04029-N"},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","first-page":"10887","DOI":"10.1073\/pnas.96.19.10887","article-title":"Characterization of a manganese-dependent regulatory protein, TroR, from Treponema pallidum","volume":"96","author":"Posey J. E.","year":"1999","unstructured":"Posey J. E. Hardham J. M. Norris S. J. Gherardini F. C. Characterization of a manganese-dependent regulatory protein, TroR, from Treponema pallidum.Proc. Natl. Acad. Sci. USA9619991088710892","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01811.x"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)68927-1"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.32.1.407-410.1981"},{"key":"e_1_3_2_46_2","unstructured":"Sambrook\nJ.\nFritsch\nE. F.\nManiatis\nT.\nMolecular cloning: a laboratory manual\n2nd ed.\n1989\nCold Spring Harbor Laboratory Press\nCold Spring Harbor N.Y"},{"key":"e_1_3_2_47_2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1574-6968.1992.tb05302.x","article-title":"Improved methods for electroporation of Staphylococcus aureus","volume":"94","author":"Schenk S.","year":"1992","unstructured":"Schenk S. Ladagga R. A. Improved methods for electroporation of Staphylococcus aureus.FEMS Microbiol. Lett.941992133138","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_2_48_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0003-2697(87)90612-9","article-title":"Universal chemical assay for the detection and determination of siderophores","volume":"160","author":"Schwyn B.","year":"1987","unstructured":"Schwyn B. Neilands J. B. Universal chemical assay for the detection and determination of siderophores.Anal. Biochem.16019874756","journal-title":"Anal. Biochem."},{"key":"e_1_3_2_49_2","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1073\/pnas.87.1.384","article-title":"Manganese-dependent disproportionation of hydrogen peroxide in bicarbonate buffer","volume":"87","author":"Stadtman E. R.","year":"1990","unstructured":"Stadtman E. R. Berlett B. S. Chock P. B. Manganese-dependent disproportionation of hydrogen peroxide in bicarbonate buffer.Proc. Natl. Acad. Sci. USA871990384388","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_50_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-2958.1994.tb01280.x","article-title":"Iron, DtxR, and regulation of diphtheria toxin expression","volume":"14","author":"Tao X.","year":"1999","unstructured":"Tao X. Schiering N. Zeng H. Y. Ringe D. Murphy J. R. Iron, DtxR, and regulation of diphtheria toxin expression.Mol. Microbiol.141999191197","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_51_2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nm0597-567","article-title":"The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol","volume":"3","author":"Telenti A.","year":"1997","unstructured":"Telenti A. Philipp W. J. Sreevatsan S. Bernasconi C. Stockbauer K. E. Wieles B. Musser J. M. Jacobs W. R. The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol.Nat. Med.31997567570","journal-title":"Nat. Med."},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.9.2305-2314.1995"},{"key":"e_1_3_2_53_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1574-6968.1996.tb08373.x","article-title":"Iron depletion and virulence in Staphylococcus aureus","volume":"141","author":"Trivier D.","year":"1996","unstructured":"Trivier D. Courcol R. J. Iron depletion and virulence in Staphylococcus aureus.FEMS Microbiol. Lett.1411996117127","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.20.6371-6376.1999"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.7.1750-1758.1998"},{"key":"e_1_3_2_56_2","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1099\/00221287-144-11-3159","article-title":"Isolation and characterisation of Staphylococcus aureus starvation-induced, stationary phase mutants defective in survival or recovery","volume":"144","author":"Watson S. P.","year":"1998","unstructured":"Watson S. P. Antonio M. A. Foster S. J. Isolation and characterisation of Staphylococcus aureus starvation-induced, stationary phase mutants defective in survival or recovery.Microbiology144199831593169","journal-title":"Microbiology"},{"key":"e_1_3_2_57_2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF00191543","article-title":"Bacterial transferrin receptor\u2014structure, function and contribution to virulence","volume":"181","author":"Williams P.","year":"1992","unstructured":"Williams P. Griffiths E. Bacterial transferrin receptor\u2014structure, function and contribution to virulence.Med. Microbiol. Immunol.1811992301322","journal-title":"Med. Microbiol. Immunol."},{"key":"e_1_3_2_58_2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1574-6976.1993.tb00026.x","article-title":"Iron uptake mechanisms of pathogenic bacteria","volume":"12","author":"Wooldridge K. G.","year":"1993","unstructured":"Wooldridge K. G. Williams P. H. Iron uptake mechanisms of pathogenic bacteria.FEMS Microbiol. Rev.121993325348","journal-title":"FEMS Microbiol. Rev."},{"key":"e_1_3_2_59_2","first-page":"659","article-title":"Molecular characterisation of the ferric uptake regulator, Fur, from Staphylococcus aureus","volume":"146","author":"Xiong A.","year":"2000","unstructured":"Xiong A. Singh V. K. Cabrera G. Jayaswal R. K. Molecular characterisation of the ferric uptake regulator, Fur, from Staphylococcus aureus.Microbiology1462000659668","journal-title":"Microbiology"},{"key":"e_1_3_2_60_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-1119(87)90468-9","article-title":"The nucleotide sequence and gene organization of the gerA spore germination operon of Bacillus subtilis 168","volume":"51","author":"Zuberi A. R.","year":"1987","unstructured":"Zuberi A. R. Moir A. Feavers I. M. The nucleotide sequence and gene organization of the gerA spore germination operon of Bacillus subtilis 168.Gene511987111","journal-title":"Gene"}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.183.2.468-475.2001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.183.2.468-475.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T14:00:12Z","timestamp":1627567212000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JB.183.2.468-475.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1,15]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,1,15]]}},"alternative-id":["10.1128\/JB.183.2.468-475.2001"],"URL":"https:\/\/doi.org\/10.1128\/jb.183.2.468-475.2001","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1,15]]},"assertion":[{"value":"2000-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-10-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}