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Furthermore, the protein and transcript levels in<jats:italic>gyrB<\/jats:italic>mutants were greater than those in experimentally heat-shocked cultures of wild-type<jats:italic>B. burgdorferi<\/jats:italic>. Circular DNA in the<jats:italic>gyrB<\/jats:italic>mutants was more relaxed than in wild-type cells, although<jats:italic>groEL<\/jats:italic>is on the linear chromosome of<jats:italic>B. burgdorferi<\/jats:italic>. To our knowledge, this is the first evidence, albeit indirect, for the effect of DNA topology on gene expression from a linear DNA molecule in a bacterium.<\/jats:p>","DOI":"10.1128\/jb.183.21.6069-6072.2002","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T21:24:28Z","timestamp":1034198668000},"page":"6069-6072","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["<i>groEL<\/i>Expression in<i>gyrB<\/i>Mutants of<i>Borrelia burgdorferi<\/i>"],"prefix":"10.1128","volume":"184","author":[{"given":"Janet","family":"Alverson","sequence":"first","affiliation":[{"name":"Division of Biological Sciences, The University of Montana, Missoula, Montana 59812"},{"name":"Biological Control and Mass Rearing Research Unit, USDA Agricultural Research Service, Mississippi State, Mississippi 39762"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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