{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T17:34:48Z","timestamp":1722706488735},"reference-count":65,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2001,2,15]],"date-time":"2001-02-15T00:00:00Z","timestamp":982195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2001,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A cluster of 18 open reading frames (ORFs), 15 of which are homologous to genes involved in division and cell wall synthesis, has been identified in\n            <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n            and\n            <jats:italic>Neisseria meningitidis<\/jats:italic>\n            . The three additional ORFs, internal to the\n            <jats:italic>dcw<\/jats:italic>\n            cluster, are not homologous to\n            <jats:italic>dcw<\/jats:italic>\n            -related genes present in other bacterial species. Analysis of the\n            <jats:italic>N. meningitidis<\/jats:italic>\n            strain MC58 genome for foreign DNA suggests that these additional ORFs have not been acquired by recent horizontal exchange, indicating that they are a long-standing, integral part of the neisserial\n            <jats:italic>dcw<\/jats:italic>\n            gene cluster. Reverse transcription-PCR analysis of RNA extracted from\n            <jats:italic>N. gonorrhoeae<\/jats:italic>\n            strain FA19 confirmed that all three ORFs are transcribed in gonococci. One of these ORFs (\n            <jats:italic>dca<\/jats:italic>\n            , for division cluster competence associated), located between\n            <jats:italic>murE<\/jats:italic>\n            and\n            <jats:italic>murF<\/jats:italic>\n            , was studied in detail and found to be essential for competence in the gonococcal but not in the meningococcal strains tested. Computer analysis predicts that\n            <jats:italic>dca<\/jats:italic>\n            encodes an inner membrane protein similar to hypothetical proteins produced by other gram-negative bacteria. In some meningococcal strains\n            <jats:italic>dca<\/jats:italic>\n            is prematurely terminated following a homopolymeric tract of G's, the length of which differs between isolates of\n            <jats:italic>N. meningitidis<\/jats:italic>\n            , suggesting that\n            <jats:italic>dca<\/jats:italic>\n            is phase variable in this species. A deletion and insertional mutation was made in the\n            <jats:italic>dca<\/jats:italic>\n            gene of\n            <jats:italic>N. gonorrhoeae<\/jats:italic>\n            strain FA19 and\n            <jats:italic>N. meningitidis<\/jats:italic>\n            strain NMB. This mutation abrogated the ability of the gonococci to be transformed with chromosomal DNA. Thus, we conclude that the\n            <jats:italic>dca<\/jats:italic>\n            -encoded gene product is an essential competence factor for gonococci.\n          <\/jats:p>","DOI":"10.1128\/jb.183.4.1233-1241.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:03:59Z","timestamp":1027764239000},"page":"1233-1241","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["A Putatively Phase Variable Gene (\n            <i>dca<\/i>\n            ) Required for Natural Competence in\n            <i>Neisseria gonorrhoeae<\/i>\n            but Not\n            <i>Neisseria meningitidis<\/i>\n            Is Located within the Division Cell Wall (\n            <i>dcw<\/i>\n            ) Gene Cluster"],"prefix":"10.1128","volume":"183","author":[{"given":"Lori A. 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