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Plasmid acquisition is likely to have been a key element in this evolutionary leap from an enteric to a flea-transmitted systemic pathogen. However, the origin of\n            <jats:italic>Y. pestis<\/jats:italic>\n            -specific plasmids remains obscure. We demonstrate specific plasmid rearrangements in different\n            <jats:italic>Y. pestis<\/jats:italic>\n            strains which distinguish\n            <jats:italic>Y. pestis<\/jats:italic>\n            bv. Orientalis strains from other biovars. We also present evidence for plasmid-associated DNA exchange between\n            <jats:italic>Y. pestis<\/jats:italic>\n            and the exclusively human pathogen\n            <jats:italic>Salmonella enterica<\/jats:italic>\n            serovar Typhi.\n          <\/jats:p>","DOI":"10.1128\/jb.183.8.2586-2594.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:01:09Z","timestamp":1027764069000},"page":"2586-2594","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":48,"title":["<i>Yersinia pestis<\/i>\n            pFra Shows Biovar-Specific Differences and Recent Common Ancestry with a\n            <i>Salmonella enterica<\/i>\n            Serovar Typhi Plasmid"],"prefix":"10.1128","volume":"183","author":[{"given":"Michael B.","family":"Prentice","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Medical Microbiology, St. Bartholomew's and the Royal London School of Medicine and Dentistry,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith D.","family":"James","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->The Sanger Centre, Wellcome Trust Genome Campus, Hinxton,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Parkhill","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->The Sanger Centre, Wellcome Trust Genome Campus, Hinxton,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Baker","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->The Sanger Centre, Wellcome Trust Genome Campus, Hinxton,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Stevens","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->The Sanger Centre, Wellcome Trust Genome Campus, Hinxton,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark N.","family":"Simmonds","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->The Sanger Centre, Wellcome Trust Genome Campus, Hinxton,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Mungall","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->The Sanger Centre, Wellcome Trust Genome Campus, Hinxton,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Churcher","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->The Sanger Centre, Wellcome Trust Genome Campus, Hinxton,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra C. 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