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Mutant NP4 formed ectopic septa at intervals along substrate hyphae, and each of the compartments developed into a spore which was indistinguishable from an aerial spore in size, shape, and thickness of the spore wall and in susceptibility to lysozyme and heat. The ectopic spores of NP4 formed in liquid medium differed from \u201csubmerged spores\u201d in lysozyme sensitivity. Shotgun cloning experiments with a library of the chromosomal DNA of the parental strain and mutant NP4 as the host gave rise to DNA fragments giving two different phenotypes; one complementing the bald phenotype of the host, and the other causing much severe wrinkled morphology in the host. Subcloning identified a gene (\n            <jats:italic>dasR<\/jats:italic>\n            ) encoding a transcriptional repressor belonging to the GntR family that was responsible for the reversal of the bald phenotype and a gene (\n            <jats:italic>dasA<\/jats:italic>\n            ) encoding a lipoprotein probably serving as a substrate-binding protein in an ATP-binding cassette (ABC) transport system that was responsible for the severe wrinkled morphology. These genes were adjacent but divergently encoded. Two genes, named\n            <jats:italic>dasB<\/jats:italic>\n            and\n            <jats:italic>dasC<\/jats:italic>\n            , encoding a membrane-spanning protein were present downstream of\n            <jats:italic>dasA<\/jats:italic>\n            , which suggested that\n            <jats:italic>dasRABC<\/jats:italic>\n            comprises a gene cluster for an ABC transporter, probably for sugar import.\n            <jats:italic>dasR<\/jats:italic>\n            was transcribed actively during vegetative growth, and\n            <jats:italic>dasA<\/jats:italic>\n            was transcribed just after commencement of aerial hypha formation and during sporulation, indicating that both were developmentally regulated. Transcriptional analysis and direct sequencing of\n            <jats:italic>dasRA<\/jats:italic>\n            in mutant NP4 suggested a defect of this mutant in the regulatory system to control the expression of these genes. Introduction of multicopies of\n            <jats:italic>dasA<\/jats:italic>\n            into the wild-type strain caused ectopic septation in very young substrate hyphae after only 1 day of growth and subsequent sporulation in response to glucose. The ectopic spores of the wild type had a thinner wall than those of mutant NP4, in agreement with the observation that the former was sensitive to lysozyme and heat. Disruption of the chromosomal\n            <jats:italic>dasA<\/jats:italic>\n            or\n            <jats:italic>dasR<\/jats:italic>\n            in the wild-type strain resulted in growth as substrate mycelium, suggesting an additional role of these genes in aerial mycelium formation. The ectopic septation and sporulation in mutant NP4 and the wild-type strain carrying multicopies of\n            <jats:italic>dasA<\/jats:italic>\n            were independent of a microbial hormone, A-factor (2-isocapryloyl-3\n            <jats:italic>R<\/jats:italic>\n            -hydroxymethyl-\u03b3-butyrolactone), that acts as a master switch of aerial mycelium formation and secondary metabolism.\n          <\/jats:p>","DOI":"10.1128\/jb.184.1.91-103.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:01:09Z","timestamp":1027764069000},"page":"91-103","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["ATP-Binding Cassette Transport System Involved in Regulation of Morphological Differentiation in Response to Glucose in\n            <i>Streptomyces griseus<\/i>"],"prefix":"10.1128","volume":"184","author":[{"given":"Jeong-Woo","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Graduate School of Agriculture and Life Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Graduate School of Agriculture and Life Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiko","family":"Hirata","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sueharu","family":"Horinouchi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Graduate School of Agriculture and Life Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.9.5470-5476.1990"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0304-4165(99)00168-3","volume":"1473","year":"1999","unstructured":"Amado, M., R. 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