{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:32:27Z","timestamp":1793655147811,"version":"4.5.1"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2002,1,15]],"date-time":"2002-01-15T00:00:00Z","timestamp":1011052800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2002,1,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            By using a panel of 603 commensal and pathogenic\n            <jats:italic>Escherichia coli<\/jats:italic>\n            and\n            <jats:italic>Shigella<\/jats:italic>\n            isolates, we showed that mutation rates of strains vary considerably among different ecotypes. Uropathogenic strains had the highest frequency of mutators, while strains from patients with bacteremia had the lowest mutation rates. No correlation between the mutation rates and antibiotic resistance was observed among the studied strains.\n          <\/jats:p>","DOI":"10.1128\/jb.184.2.605-609.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:01:09Z","timestamp":1027764069000},"page":"605-609","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":158,"title":["High Frequency of Mutator Strains among Human Uropathogenic\n            <i>Escherichia coli<\/i>\n            Isolates"],"prefix":"10.1128","volume":"184","author":[{"given":"Erick","family":"Denamur","sequence":"first","affiliation":[{"name":"INSERM U 458"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ste\u0301phane","family":"Bonacorsi","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019E\u0301tude de Ge\u0301ne\u0301tique Bacte\u0301rienne dans les Infections de l\u2019Enfant (EA3105)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Giraud","sequence":"additional","affiliation":[{"name":"Ho\u0302pital Robert Debre\u0301, INSERM EPI 9916, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades, Universite\u0301 Rene\u0301 Descartes\u2014Paris V"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Duriez","sequence":"additional","affiliation":[{"name":"INSERM U 458"},{"name":"Ho\u0302pital Robert Debre\u0301, INSERM EPI 9916, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades, Universite\u0301 Rene\u0301 Descartes\u2014Paris V"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida","family":"Hilali","sequence":"additional","affiliation":[{"name":"INSERM EPI 9933, Ho\u0302pital Bichat-Claude Bernard, AP-HP, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Amorin","sequence":"additional","affiliation":[{"name":"INSERM U 458"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Bingen","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019E\u0301tude de Ge\u0301ne\u0301tique Bacte\u0301rienne dans les Infections de l\u2019Enfant (EA3105)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Andremont","sequence":"additional","affiliation":[{"name":"INSERM EPI 9933, Ho\u0302pital Bichat-Claude Bernard, AP-HP, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Picard","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie, Ho\u0302pital Morvan, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc\u0327ois","family":"Taddei","sequence":"additional","affiliation":[{"name":"Ho\u0302pital Robert Debre\u0301, INSERM EPI 9916, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades, Universite\u0301 Rene\u0301 Descartes\u2014Paris V"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Matic","sequence":"additional","affiliation":[{"name":"Ho\u0302pital Robert Debre\u0301, INSERM EPI 9916, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades, Universite\u0301 Rene\u0301 Descartes\u2014Paris V"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1086\/514217","volume":"177","year":"1998","unstructured":"Bingen, E., B. Picard, N. Brahimi, S. Mathy, P. Desjardins, J. Elion, and E. Denamur. 1998. Phylogenetic analysis of Escherichia coli strains causing neonatal meningitis suggests horizontal gene transfer from a predominant pool of highly virulent B2 group strains. J. Infect. Dis.177:642\u2013650.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1126\/science.287.5457.1479","volume":"287","year":"2000","unstructured":"Bjorkman, J., I. Nagaev, O. G. Berg, D. Hughes, and D. I. Andersson. 2000. Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance. Science287:1479\u20131482.","journal-title":"Science"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0092-8674(00)00175-6","volume":"103","year":"2000","unstructured":"Denamur, E., G. Lecointre, P. Darlu, O. Tenaillon, C. Acquaviva, C. Sayada, I. Sunjevaric, R. Rothstein, J. Elion, F. Taddei, M. Radman, and I. Matic. 2000. Evolutionary implications of the frequent horizontal transfer of mismatch repair genes. Cell103:711\u2013721.","journal-title":"Cell"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1099\/00221287-147-6-1671","volume":"147","year":"2001","unstructured":"Duriez, P., O. Clermont, S. Bonacorsi, E. Bingen, A. Chaventre, J. Elion, B. Picard, and E. Denamur. 2001. Commensal Escherichia coli isolates are phylogenetically distributed among geographically distinct human populations. Microbiology (Reading)147:1671\u20131676.","journal-title":"Microbiology (Reading)"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/genetics\/154.3.959","volume":"154","year":"2000","unstructured":"Funchain, P., A. Yeung, J. L. Stewart, R. Lin, M. M. Slupska, and J. H. Miller. 2000. The consequences of growth of a mutator strain of Escherichia coli as measured by loss of function among multiple gene targets and loss of fitness. Genetics154:959\u2013970.","journal-title":"Genetics"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1126\/science.1056421","volume":"291","year":"2001","unstructured":"Giraud, A., I. Matic, O. Tenaillon, A. Clara, M. Radman, M. Fons, and F. Taddei. 2001. Costs and benefits of high mutation rates: adaptive evolution of bacteria in the mouse gut. Science291:2606\u20132608.","journal-title":"Science"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.3983-3989.2000"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.274.5290.1208","volume":"274","year":"1996","unstructured":"LeClerc, J. E., B. Li, W. L. Payne, and T. A. Cebula. 1996. High mutation frequencies among Escherichia coli and Salmonella pathogens. Science274:1208\u20131211.","journal-title":"Science"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.2.417-422.1997"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1126\/science.277.5333.1833","volume":"277","year":"1997","unstructured":"Matic, I., M. Radman, F. Taddei, B. Picard, C. Doit, E. Bingen, E. Denamur, and J. Elion. 1997. Highly variable mutation rates in commensal and pathogenic Escherichia coli.Science277:1833\u20131834.","journal-title":"Science"},{"key":"e_1_3_2_12_2","unstructured":"National Committee for Clinical Laboratory Standards. 1993. Performance for antimicrobial disk susceptibility tests 5th ed. Approved standard M2-A5. National Committee for Clinical Laboratory Standards Villanova Pa."},{"key":"e_1_3_2_13_2","unstructured":"National Committee for Clinical Laboratory Standards. 1998. Performance for antimicrobial susceptibility testing 8th informational supplement. M100-S8. National Committee for Clinical Laboratory Standards Wayne Pa."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.157.2.690-693.1984"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1126\/science.288.5469.1251","volume":"288","year":"2000","unstructured":"Oliver, A., R. Canton, P. Campo, F. Baquero, and J. Blazquez. 2000. High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science288:1251\u20131254.","journal-title":"Science"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.1.9-14.2001"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.2.546-553.1999"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1046\/j.1365-2958.2001.02408.x","volume":"40","year":"2001","unstructured":"Richardson, A. R., and I. Stojiljkovic. 2001. Mismatch repair and the regulation of phase variation in Neisseria meningitidis. Mol. Microbiol.40:645\u2013655.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/283104a0","volume":"283","year":"1980","unstructured":"Robeson, J. P., R. M. Goldschmidt, and R. D. Curtiss. 1980. Potential of Escherichia coli isolated from nature to propagate cloning vectors. Nature283:104\u2013106.","journal-title":"Nature"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1099\/00221287-144-9-2667","volume":"144","year":"1998","unstructured":"Rolland, K., N. Lambert-Zechovsky, B. Picard, and E. Denamur. 1998. Shigella and enteroinvasive Escherichia coli strains are derived from distinct ancestral strains of E. coli. Microbiology (Reading)144:2667\u20132672.","journal-title":"Microbiology (Reading)"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1322-1328.2001"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"8922","DOI":"10.1073\/pnas.95.15.8922","volume":"95","year":"1998","unstructured":"Sokurenko, E. V., V. Chesnokova, D. E. Dykhuizen, I. Ofek, X. R. Wu, K. A. Krogfelt, C. Struve, M. A. Schembri, and D. L. Hasty. 1998. Pathogenic adaptation of Escherichia coli by natural variation of the FimH adhesin. Proc. Natl. Acad. Sci. USA95:8922\u20138926.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"11736","DOI":"10.1073\/pnas.92.25.11736","volume":"92","year":"1995","unstructured":"Taddei, F., I. Matic, and M. Radman. 1995. Cyclic AMP-dependent SOS induction and mutagenesis in resting bacterial populations. Proc. Natl. Acad. Sci. USA92:11736\u201311740.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/42696","volume":"387","year":"1997","unstructured":"Taddei, F., M. Radman, J. Maynard-Smith, B. Toupance, P. H. Gouyon, and B. Godelle. 1997. Role of mutators in adaptive evolution. Nature387:700\u2013702.","journal-title":"Nature"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","unstructured":"Taddei F. M. Vulic M. Radman and I. Matic. 1997. Genetic variability and adaptation to stress p.271\u2013290. In R. Bijlsma and V. Loeschcke (ed.) Environmental stress adaptation and evolution vol. EXS 83. Birkh\u00e4user Verlag Basel Switzerland.","DOI":"10.1007\/978-3-0348-8882-0_15"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/genetics\/152.2.485","volume":"152","year":"1999","unstructured":"Tenaillon, O., B. Toupance, H. Le Nagard, F. Taddei, and B. Godelle. 1999. Mutators, population size, adaptive landscape and the adaptation of asexual populations of bacteria. Genetics152:485\u2013493.","journal-title":"Genetics"}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.184.2.605-609.2002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JB.184.2.605-609.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T18:05:50Z","timestamp":1627581950000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JB.184.2.605-609.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1,15]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,1,15]]}},"alternative-id":["10.1128\/JB.184.2.605-609.2002"],"URL":"https:\/\/doi.org\/10.1128\/jb.184.2.605-609.2002","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1,15]]},"assertion":[{"value":"2001-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}