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This protein was purified from\n                    <jats:italic>P. fluorescens<\/jats:italic>\n                    , and RNA bound to it was converted to cDNA, which served as a probe to isolate the corresponding chromosomal locus,\n                    <jats:italic>rsmZ<\/jats:italic>\n                    . This gene encoded a regulatory RNA of 127 nucleotides and a truncated form lacking 35 nucleotides at the 3\" end. Expression of\n                    <jats:italic>rsmZ<\/jats:italic>\n                    depended on GacA, increased with increasing population density, and was stimulated by the addition of a solvent-extractable extracellular signal produced by strain CHA0 at the end of exponential growth. This signal appeared to be unrelated to\n                    <jats:italic>N<\/jats:italic>\n                    -acyl-homoserine lactones. A conserved upstream element in the\n                    <jats:italic>rsmZ<\/jats:italic>\n                    promoter, but not the stress sigma factor RpoS, was involved in\n                    <jats:italic>rsmZ<\/jats:italic>\n                    expression. Overexpression of\n                    <jats:italic>rsmZ<\/jats:italic>\n                    effectively suppressed the negative effect of\n                    <jats:italic>gacS<\/jats:italic>\n                    and\n                    <jats:italic>gacA<\/jats:italic>\n                    mutations on target genes, i.e.,\n                    <jats:italic>hcnA<\/jats:italic>\n                    (for hydrogen cyanide synthase) and\n                    <jats:italic>aprA<\/jats:italic>\n                    (for the major exoprotease). Mutational inactivation of\n                    <jats:italic>rsmZ<\/jats:italic>\n                    resulted in reduced expression of these target genes in the presence of added signal. Overexpression of\n                    <jats:italic>rsmA<\/jats:italic>\n                    had a similar, albeit stronger negative effect. These results support a model in which GacA upregulates the expression of regulatory RNAs, such as RsmZ of strain CHA0, in response to a bacterial signal. By a titration effect, RsmZ may then alleviate the repressing activity of RsmA on the expression of target mRNAs.\n                  <\/jats:p>","DOI":"10.1128\/jb.184.4.1046-1056.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T05:55:53Z","timestamp":1027749353000},"page":"1046-1056","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":335,"title":["Regulatory RNA as Mediator in GacA\/RsmA-Dependent Global Control of Exoproduct Formation in\n                    <i>Pseudomonas fluorescens<\/i>\n                    CHA0"],"prefix":"10.1128","volume":"184","author":[{"given":"Stephan","family":"Heeb","sequence":"first","affiliation":[{"name":"Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Blumer","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Haas","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.14.3913-3919.2000"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1046\/j.1365-2958.2000.01734.x","volume":"35","year":"2000","unstructured":"Altier, C., M. 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