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The LraI family of lipoproteins in viridans group streptococci and other bacteria have been shown to function as virulence factors, adhesins, or ABC-type metal transporters. We previously reported the identification of the<jats:italic>S. mutans<\/jats:italic>LraI operon,<jats:italic>sloABCR<\/jats:italic>, which encodes components of a putative metal uptake system composed of SloA, an ATP-binding protein, SloB, an integral membrane protein, and SloC, a solute-binding lipoprotein, as well as a metal-dependent regulator, SloR. We report here the functional analysis of this operon. By Western blotting, addition of Mn to the growth medium repressed SloC expression in a wild-type strain but not in a<jats:italic>sloR<\/jats:italic>mutant. Other metals tested had little effect. Cells were also tested for aerobic growth in media stripped of metals then reconstituted with Mg and either Mn or Fe. Fe at 10 \u03bcM supported growth of the wild-type strain but not of a<jats:italic>sloA<\/jats:italic>or<jats:italic>sloC<\/jats:italic>mutant. Mn at 0.1 \u03bcM supported growth of the wild-type strain and<jats:italic>sloR<\/jats:italic>mutant but not of<jats:italic>sloA<\/jats:italic>or<jats:italic>sloC<\/jats:italic>mutants. The combined results suggest that the SloABC proteins transport both metals, although the SloR protein represses this system only in response to Mn. These conclusions are supported by<jats:sup>55<\/jats:sup>Fe uptake studies with Mn as a competitor. Finally, a<jats:italic>sloA<\/jats:italic>mutant demonstrated loss of virulence in a rat model of endocarditis, suggesting that metal transport is required for endocarditis pathogenesis.<\/jats:p>","DOI":"10.1128\/jb.185.20.5967-5975.2003","type":"journal-article","created":{"date-parts":[[2003,10,2]],"date-time":"2003-10-02T22:52:58Z","timestamp":1065135178000},"page":"5967-5975","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":99,"title":["The<i>sloABCR<\/i>Operon of<i>Streptococcus mutans<\/i>Encodes an Mn and Fe Transport System Required for Endocarditis Virulence and Its Mn-Dependent Repressor"],"prefix":"10.1128","volume":"185","author":[{"given":"Sehmi","family":"Paik","sequence":"first","affiliation":[{"name":"The Philips Institute of Oral and Craniofacial Molecular Biology"},{"name":"Department of Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunsri","family":"Brown","sequence":"additional","affiliation":[{"name":"The Philips Institute of Oral and Craniofacial Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy L.","family":"Munro","sequence":"additional","affiliation":[{"name":"Department of Adult Health Nursing, Virginia Commonwealth University, Richmond, Virginia 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia Nau","family":"Cornelissen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Kitten","sequence":"additional","affiliation":[{"name":"The Philips Institute of Oral and Craniofacial Molecular Biology"},{"name":"Department of Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1136\/heart.85.1.66","volume":"85","year":"2001","unstructured":"Al-Karaawi, Z. 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