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This phage\ntransmits\n            <jats:italic>ctxAB<\/jats:italic>\n            genes between\n            <jats:italic>V. cholerae<\/jats:italic>\n            bacterial\npopulations that express toxin-coregulated pilus (TCP), the\nCTX\u03c6 receptor. In investigating new forms of\n            <jats:italic>ctxAB<\/jats:italic>\n            transmission, we found that\n            <jats:italic>V. cholerae<\/jats:italic>\n            filamentous phage\nVGJ\u03c6, which uses the mannose-sensitive hemagglutinin (MSHA)\npilus as a receptor, transmits CTX\u03c6 or its satellite phage RS1\nby an efficient and highly specific TCP-independent mechanism. This is\na novel type of specialized transduction consisting in the\nsite-specific cointegration of VGJ\u03c6 and CTX\u03c6 (or RS1)\nreplicative forms to produce a single hybrid molecule, which generates\na single-stranded DNA hybrid genome that is packaged into hybrid viral\nparticles designated HybP\u03c6 (for the VGJ\u03c6\/CTX\u03c6\nhybrid) and HybRS\u03c6 (for the VGJ\u03c6\/RS1 hybrid). The\nhybrid phages replicate by using the VGJ\u03c6 replicating functions\nand use the VGJ\u03c6 capsid, retaining the ability to infect via\nMSHA. The hybrid phages infect most tested strains more efficiently\nthan CTX\u03c6, even under in vitro optimal conditions for TCP\nexpression. Infection and lysogenization with HybP\u03c6 revert the\n            <jats:italic>V. cholerae<\/jats:italic>\n            live attenuated vaccine strain 1333 to virulence.\nOur results reinforce that TCP is not indispensable for the acquisition\nof CTX\u03c6. Thus, we discuss an alternative to the current\naccepted evolutionary model for the emergence of new toxigenic strains\nof\n            <jats:italic>V. cholerae<\/jats:italic>\n            and the importance of our findings for the\ndevelopment of an environmentally safer live attenuated cholera\nvaccine.\n          <\/jats:p>","DOI":"10.1128\/jb.185.24.7231-7240.2003","type":"journal-article","created":{"date-parts":[[2003,12,2]],"date-time":"2003-12-02T01:43:08Z","timestamp":1070329388000},"page":"7231-7240","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":47,"title":["Novel Type of Specialized Transduction forCTX\u03c6 or Its Satellite Phage RS1 Mediated by Filamentous PhageVGJ\u03c6 in\n            <i>Vibriocholerae<\/i>"],"prefix":"10.1128","volume":"185","author":[{"given":"Javier","family":"Campos","sequence":"first","affiliation":[{"name":"Departamento\rde Gene\u0301tica, Centro Nacional de Investigaciones\rCienti\u0301ficas, AP 6412, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriel","family":"Marti\u0301nez","sequence":"additional","affiliation":[{"name":"Departamento\rde Gene\u0301tica, Centro Nacional de Investigaciones\rCienti\u0301ficas, AP 6412, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Marrero","sequence":"additional","affiliation":[{"name":"Departamento\rde Gene\u0301tica, Centro Nacional de Investigaciones\rCienti\u0301ficas, AP 6412, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yussuan","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento\rde Gene\u0301tica, Centro Nacional de Investigaciones\rCienti\u0301ficas, AP 6412, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris L.","family":"Rodri\u0301guez","sequence":"additional","affiliation":[{"name":"Departamento\rde Gene\u0301tica, Centro Nacional de Investigaciones\rCienti\u0301ficas, AP 6412, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Suzarte","sequence":"additional","affiliation":[{"name":"Departamento\rde Gene\u0301tica, Centro Nacional de Investigaciones\rCienti\u0301ficas, AP 6412, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talena","family":"Ledo\u0301n","sequence":"additional","affiliation":[{"name":"Departamento\rde Gene\u0301tica, Centro Nacional de Investigaciones\rCienti\u0301ficas, AP 6412, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Fando","sequence":"additional","affiliation":[{"name":"Departamento\rde Gene\u0301tica, Centro Nacional de Investigaciones\rCienti\u0301ficas, AP 6412, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Ausubel F. 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