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In\n                    <jats:italic>rpoN<\/jats:italic>\n                    mutants lacking the transcription factor \u03c3\n                    <jats:sup>54<\/jats:sup>\n                    , the expression of the\n                    <jats:italic>lasR<\/jats:italic>\n                    and\n                    <jats:italic>lasI<\/jats:italic>\n                    genes was elevated at low cell densities, whereas expression of the\n                    <jats:italic>rhlR<\/jats:italic>\n                    and\n                    <jats:italic>rhlI<\/jats:italic>\n                    genes was markedly enhanced throughout growth by comparison with the wild type and the complemented mutant strains. As a consequence, the\n                    <jats:italic>rpoN<\/jats:italic>\n                    mutants had elevated levels of both signal molecules and overexpressed the biosynthetic genes for elastase, rhamnolipids, and hydrogen cyanide. The quorum-sensing regulatory protein QscR was not involved in the negative control exerted by RpoN. By contrast, in an\n                    <jats:italic>rpoN<\/jats:italic>\n                    mutant, the expression of the\n                    <jats:italic>gacA<\/jats:italic>\n                    global regulatory gene was significantly increased during the entire growth cycle, whereas another global regulatory gene,\n                    <jats:italic>vfr<\/jats:italic>\n                    , was downregulated at high cell densities. In conclusion, it appears that GacA levels play an important role, probably indirectly, in the RpoN-dependent modulation of the quorum-sensing machinery of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1128\/jb.185.7.2227-2235.2003","type":"journal-article","created":{"date-parts":[[2003,3,18]],"date-time":"2003-03-18T20:33:26Z","timestamp":1048019606000},"page":"2227-2235","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":134,"title":["Negative Control of Quorum Sensing by RpoN (\u03c3\n                    <sup>54<\/sup>\n                    ) in\n                    <i>Pseudomonas aeruginosa<\/i>\n                    PAO1"],"prefix":"10.1128","volume":"185","author":[{"given":"Karin","family":"Heurlier","sequence":"first","affiliation":[{"name":"Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"De\u0301nervaud","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Pessi","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Reimmann","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Haas","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Microbienne, Universite\u0301 de Lausanne, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.12.3928-3935.1997"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.17.5574-5581.1997"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0378-1119(91)90604-A","volume":"109","year":"1991","unstructured":"Bao, Y., D. 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