{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:53:56Z","timestamp":1792148036348,"version":"4.4.0"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We present the 4.8-Mb complete genome sequence of\n            <jats:italic>Salmonella<\/jats:italic>\n            <jats:italic>enterica<\/jats:italic>\n            serovar Typhi strain Ty2, a human-specific pathogen causing typhoid fever. A comparison with the genome sequence of recently isolated\n            <jats:italic>S<\/jats:italic>\n            .\n            <jats:italic>enterica<\/jats:italic>\n            serovar Typhi strain CT18 showed that 29 of the 4,646 predicted genes in Ty2 are unique to this strain, while 84 genes are unique to CT18. Both genomes contain more than 200 pseudogenes; 9 of these genes in CT18 are intact in Ty2, while 11 intact CT18 genes are pseudogenes in Ty2. A half-genome interreplichore inversion in Ty2 relative to CT18 was confirmed. The two strains exhibit differences in prophages, insertion sequences, and island structures. While CT18 carries two plasmids, one conferring multiple drug resistance, Ty2 has no plasmids and is sensitive to antibiotics.\n          <\/jats:p>","DOI":"10.1128\/jb.185.7.2330-2337.2003","type":"journal-article","created":{"date-parts":[[2003,3,19]],"date-time":"2003-03-19T01:33:26Z","timestamp":1048037606000},"page":"2330-2337","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":295,"title":["Comparative Genomics of\n            <i>Salmonella<\/i>\n            <i>enterica<\/i>\n            Serovar Typhi Strains Ty2 and CT18"],"prefix":"10.1128","volume":"185","author":[{"given":"Wen","family":"Deng","sequence":"first","affiliation":[{"name":"Laboratory of Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shian-Ren","family":"Liou","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Guy","family":"Plunkett","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George F.","family":"Mayhew","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra J.","family":"Rose","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Burland","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Voula","family":"Kodoyianni","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics"},{"name":"Genome Center of Wisconsin, University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics"},{"name":"Genome Center of Wisconsin, University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick R.","family":"Blattner","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1093\/nar\/27.19.3911","volume":"27","year":"1999","unstructured":"Besemer, J., and M. 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